Changes in the central nervous system in diabetic neuropathy
One of the most common chronic complications arising from diabetes is diabetic peripheral neuropathy. Depending on research statistics, approximately half of the people who have diabetes will suffer from diabetic peripheral neuropathy over time, which manifests as abnormal sensations in the distal e...
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| Published in: | Heliyon Vol. 9; no. 8; p. e18368 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Elsevier Ltd
01-08-2023
Elsevier |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | One of the most common chronic complications arising from diabetes is diabetic peripheral neuropathy. Depending on research statistics, approximately half of the people who have diabetes will suffer from diabetic peripheral neuropathy over time, which manifests as abnormal sensations in the distal extremities, and about 25%–50% of these patients have symptoms of neuralgia, called painful diabetic neuropathy. These patients often exhibit adverse emotional conditions, like anxiety or depression, which can reduce their quality of life. The pathogenesis of diabetic peripheral neuropathy is complex, and although persistent hyperglycemia plays a central role in the development of diabetic peripheral neuropathy, strict glycemic control does not eliminate the risk of diabetic peripheral neuropathy. This suggests the need to understand the role of the central nervous system in the development of diabetic peripheral neuropathy to modulate treatment regimens accordingly. Magnetic resonance imaging not only allows for the noninvasive detection of structural and functional alterations in the central nervous system, but also provides insight into the processing of abnormal information such as pain by the central nervous system, and most importantly, contributes to the development of more effective pain relief protocols. Therefore, this article will focus on the mechanisms and related imaging evidence of central alterations in diabetic peripheral neuropathy, especially in painful diabetic neuropathy.
•The mechanism of peripheral sensitization and central sensitization caused by nerve injury is introduced to provide new ideas for basic research and treatment of diabetic painful neuropathy.•Magnetic resonance imaging studies have shown that DPN is not limited to peripheral nerve damage, but also has central nervous system involvement, and magnetic resonance imaging is an important tool for diagnosing central involvement in diabetic peripheral neuropathy.•Magnetic resonance imaging techniques can explore the underlying pathological pain mechanisms of diabetic peripheral neuropathy and help to develop targeted pain relief measures. |
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| Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| ISSN: | 2405-8440 2405-8440 |
| DOI: | 10.1016/j.heliyon.2023.e18368 |