Acute administration of 5-oxoproline induces oxidative damage to lipids and proteins and impairs antioxidant defenses in cerebral cortex and cerebellum of young rats

5-Oxoproline accumulates in glutathione synthetase deficiency, an autossomic recessive inherited disorder clinically characterized by hemolytic anemia, metabolic acidosis, and severe neurological symptoms whose mechanisms are poorly known. In the present study we investigated the effects of acute su...

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Published in:	Metabolic brain disease Vol. 25; no. 2; pp. 145 - 154
Main Authors:	Pederzolli, Carolina Didonet, Mescka, Caroline Paula, Zandoná, Bernardo Remuzzi, de Moura Coelho, Daniella, Sgaravatti, Ângela Malysz, Sgarbi, Mirian Bonaldi, de Souza Wyse, Angela Terezinha, Duval Wannmacher, Clóvis Milton, Wajner, Moacir, Vargas, Carmen Regla, Dutra-Filho, Carlos Severo
Format:	Journal Article
Language:	English
Published:	Boston Boston : Springer US 01-06-2010 Springer US Springer Nature B.V
Subjects:	5-Oxoproline Age Factors Animals Antioxidant defenses Antioxidants - metabolism Antioxidants - physiology Biochemistry Biomedical and Life Sciences Biomedicine Brain Diseases, Metabolic, Inborn - chemically induced Brain Diseases, Metabolic, Inborn - metabolism Cerebellum - drug effects Cerebellum - metabolism Cerebrum - drug effects Cerebrum - metabolism Disease Models, Animal Glutathione Synthase - deficiency Glutathione synthetase deficiency Lipid Peroxidation - drug effects Lipid Peroxidation - physiology Metabolic Diseases Nerve Tissue Proteins - metabolism Nerve Tissue Proteins - physiology Neurology Neurosciences Oncology Original Paper oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Pyrrolidonecarboxylic Acid - metabolism Pyrrolidonecarboxylic Acid - toxicity Rats Rats, Wistar Oxidative stress Glutathione synthetase deficiency Antioxidant defenses 5-Oxoproline
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Summary:	5-Oxoproline accumulates in glutathione synthetase deficiency, an autossomic recessive inherited disorder clinically characterized by hemolytic anemia, metabolic acidosis, and severe neurological symptoms whose mechanisms are poorly known. In the present study we investigated the effects of acute subcutaneous administration of 5-oxoproline to verify whether oxidative stress is elicited by this metabolite in vivo in cerebral cortex and cerebellum of 14-day-old rats. Our results showed that the acute administration of 5-oxoproline is able to promote both lipid and protein oxidation, to impair brain antioxidant defenses, to alter SH/SS ratio and to enhance hydrogen peroxide content, thus promoting oxidative stress in vivo, a mechanism that may be involved in the neuropathology of gluthatione synthetase deficiency.
Bibliography:	http://dx.doi.org/10.1007/s11011-010-9190-1 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0885-7490 1573-7365
DOI:	10.1007/s11011-010-9190-1