Search Results - "Zandi, Trevor A."

The dabABC operon is a marker of C4-alkylated monobactam biosynthesis and responsible for (2S,3R)-diaminobutyrate production by Li, Rongfeng, Lichstrahl, Michael S., Zandi, Trevor A., Kahlert, Lukas, Townsend, Craig A.

“…Non-ribosomal peptide synthetases (NRPSs) assemble metabolites of medicinal and commercial value. Both serine and threonine figure prominently in these…”
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Competing off-loading mechanisms of meropenem from an L,D-transpeptidase reduce antibiotic effectiveness by Zandi, Trevor A., Townsend, Craig A.

“…The carbapenem family of β-lactam antibiotics displays a remarkably broad spectrum of bactericidal activity, exemplified by meropenem’s phase II clinical trial…”
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Non-classical transpeptidases yield insight into new antibacterials by Kumar, Pankaj, Kaushik, Amit, Lloyd, Evan P, Li, Shao-Gang, Mattoo, Rohini, Ammerman, Nicole C, Bell, Drew T, Perryman, Alexander L, Zandi, Trevor A, Ekins, Sean, Ginell, Stephan L, Townsend, Craig A, Freundlich, Joel S, Lamichhane, Gyanu

“…Carbapenem β-lactam antibiotics target non-classical transpeptidases, the L,D -transpeptidases, which act in an alternative Mycobacterium tuberculosis…”
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Synthesis of functionalized 2,3-diaminopropionates and their potential for directed monobactam biosynthesis by Lichstrahl, Michael S, Kahlert, Lukas, Li, Rongfeng, Zandi, Trevor A, Yang, Jerry, Townsend, Craig. A

“…The N -sulfonated monobactams harbor considerable potential to combat emerging bacterial infections that are problematic to treat due to their…”
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The dabABC operon is a marker of C4-alkylated monobactam biosynthesis and responsible for (2S,3R)-diaminobutyrate production by Li, Rongfeng, Lichstrahl, Michael S., Zandi, Trevor A., Kahlert, Lukas, Townsend, Craig A.

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Phylogenetic and Biochemical Analyses of Mycobacterial l,d-Transpeptidases Reveal a Distinct Enzyme Class That Is Preferentially Acylated by Meropenem by Zandi, Trevor A, Marshburn, Robert L, Stateler, Paige K, Brammer Basta, Leighanne A

“…The genomes of diverse mycobacterial species encode multiple proteins with the canonical l,d-transpeptidase (Ldt) sequence motif. The reason for this apparent…”
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Structure–Activity Relationship of Penem Antibiotic Side Chains Used against Mycobacteria Reveals Highly Active Compounds by Batchelder, Hunter R., Zandi, Trevor A., Kaushik, Amit, Naik, Akul, Story-Roller, Elizabeth, Maggioncalda, Emily C., Lamichhane, Gyanu, Nuermberger, Eric L., Townsend, Craig A.

“…The rise of antibiotic-resistant Mycobacterium tuberculosis and non-tuberculous mycobacterial infections has placed ever-increasing importance on discovering…”
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Erratum: The dabABC operon is a marker of C4-alkylated monobactam biosynthesis and responsible for (2S,3R)-diaminobutyrate production by Li, Rongfeng, Lichstrahl, Michael S, Zandi, Trevor A, Kahlert, Lukas, Townsend, Craig A

“…[This corrects the article DOI: 10.1016/j.isci.2024.109202.]…”
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