Preemptive transcranial direct current stimulation induces analgesia, prevents chronic inflammation and fibrosis, and promotes tissue repair in a rat model of postoperative pain

[Display omitted] •Preemptive transcranial direct current stimulation induces analgesia.•Preemptive transcranial direct current stimulation prevents inflammation and fibrosis.•Preemptive transcranial direct current stimulation promotes tissue repair.•Preemptive transcranial direct current stimulatio...

Full description

Saved in:

Bibliographic Details
Published in:	Neuroscience letters Vol. 813; p. 137407
Main Authors:	Zancanaro, Mayra, Stein, Dirson J., Lopes, Bettega C., de Souza, Andressa, Ströher Toledo, Roberta, de Souza, Alessandra H., Oliveira, Sara M., Visioli, Fernanda, Sanches, Paulo R.S., Fregni, Felipe, Caumo, Wolnei, Torres, Iraci L.S.
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 14-09-2023
Subjects:	Cytokines Nociception Postoperative pain Rats Surgery Transcranial Direct Current Stimulation Nociception Rats Postoperative pain Transcranial Direct Current Stimulation Cytokines Surgery
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	[Display omitted] •Preemptive transcranial direct current stimulation induces analgesia.•Preemptive transcranial direct current stimulation prevents inflammation and fibrosis.•Preemptive transcranial direct current stimulation promotes tissue repair.•Preemptive transcranial direct current stimulation modulates BDNF levels.•Preemptive transcranial direct current stimulation modulates neuroinflammation. This study evaluated the effects of previous exposure to Transcranial Direct Current Stimulation (tDCS) on nociceptive, neuroinflammatory, and neurochemical parameters, in rats subjected to an incisional pain model. Forty adult male Wistar rats (60 days old; weighing ∼250g) were divided into five groups: 1. control (C); 2. drugs (D); 3. surgery (S); 4. surgery + sham-tDCS (SsT) and 5. surgery + tDCS (ST). Bimodal tDCS (0.5mA) was applied for 20 min/day/8 days before the incisional model. Mechanical allodynia (von Frey) was evaluated at different time points after surgery. Cytokines and BDNF levels were evaluated in the cerebral cortex, hippocampus, brainstem, and spinal cord. Histology and activity of myeloperoxidase (MPO) and N-acetyl-β-D-glucosaminidase (NAGase) were evaluated in the surgical lesion sites in the right hind paw. The results demonstrate that the surgery procedure increased BDNF and IL-6 levels in the spinal cord levels in the hippocampus, and decreased IL-1β and IL-6 levels in the cerebral cortex, IL-6 levels in the hippocampus, and IL-10 levels in the brainstem and hippocampus. In addition, preemptive tDCS was effective in controlling postoperative pain, increasing BDNF, IL-6, and IL-10 levels in the spinal cord and brainstem, increasing IL-1β in the spinal cord, and decreasing IL-6 levels in the cerebral cortex and hippocampus, IL-1β and IL-10 levels in the hippocampus. Preemptive tDCS also contributes to tissue repair, preventing chronic inflammation, and consequent fibrosis. Thus, these findings imply that preemptive methods for postoperative pain management should be considered an interesting pain management strategy, and may contribute to the development of clinical applications for tDCS in surgical situations.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0304-3940 1872-7972
DOI:	10.1016/j.neulet.2023.137407