Leukoencephalopathy, Cerebral Calcifications, and Cysts

Association of leukoencephalopathy, cerebral calcifications, and cysts (LCC) is a rare disorder that was recently described. To our knowledge, only 2 reports, including 3 patients in each, have been published in the literature to date. Herein, we report a 19-year-old man with LCC who had neurologica...

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Bibliographic Details
Published in:	American Journal of Neuroradiology Vol. 27; no. 1; pp. 200 - 203
Main Authors:	Sener, U, Zorlu, Y, Men, S, Bayol, U, Zanapalioglu, U
Format:	Journal Article
Language:	English
Published:	Oak Brook, IL Am Soc Neuroradiology 01-01-2006 American Society of Neuroradiology
Subjects:	Adult Adult and adolescent clinical studies Biological and medical sciences Brain - pathology Brain Diseases - complications Brain Diseases - diagnosis Brain Diseases - pathology Calcinosis - complications Calcinosis - diagnosis Calcinosis - pathology Cardiovascular system Cysts - complications Cysts - diagnosis Cysts - pathology Disease Progression Epilepsy, Tonic-Clonic - etiology Humans Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging Male Medical sciences Miscellaneous Mood disorders Nervous system Pediatrics Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Radiodiagnosis. Nmr imagery. Nmr spectrometry Nervous system diseases Radiodiagnosis Central nervous system Cyst Calcification Benign neoplasm Encephalon
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Summary:	Association of leukoencephalopathy, cerebral calcifications, and cysts (LCC) is a rare disorder that was recently described. To our knowledge, only 2 reports, including 3 patients in each, have been published in the literature to date. Herein, we report a 19-year-old man with LCC who had neurological symptoms beginning in late adolescence. Clinically, he had rare convulsive seizures, slowly progressive pyramidal symptoms, and normal intelligence. On radiological examination, there were progressive calcifications in the basal nuclei and the cerebral white matter, as well as parenchymal cysts and diffuse abnormal signals of the white matter on T2-weighted sequences on MR imaging. On histopathological examination, angiomatous changes and secondary gliosis were demonstrated.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Case Study-2 ObjectType-Feature-4 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0195-6108 1936-959X 1432-1920