Search Results - "Zamurs, Andra"

Design, Synthesis, and Structure−Activity Relationships of Novel 2-Substituted Pyrazinoylguanidine Epithelial Sodium Channel Blockers:  Drugs for Cystic Fibrosis and Chronic Bronchitis by Hirsh, Andrew J, Molino, Bruce F, Zhang, Jianzhong, Astakhova, Nadezhda, Geiss, William B, Sargent, Bruce J, Swenson, Brian D, Usyatinsky, Alexander, Wyle, Michael J, Boucher, Richard C, Smith, Rick T, Zamurs, Andra, Johnson, M. Ross

“…Amiloride (1), the prototypical epithelial sodium channel (ENaC) blocker, has been administered with limited success as aerosol therapy for improving pulmonary…”
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Evaluation of second generation amiloride analogs as therapy for cystic fibrosis lung disease by Hirsh, Andrew J, Sabater, Juan R, Zamurs, Andra, Smith, Rick T, Paradiso, Anthony M, Hopkins, Sam, Abraham, William M, Boucher, Richard C

“…Epithelial sodium channel (ENaC) blockers have been proposed as a therapy to restore mucus clearance (MC) in cystic fibrosis (CF) airways. The therapeutic…”
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Pharmacological properties of N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-4-[4-(2,3-dihydroxypropoxy)phenyl]butyl-guanidine methanesulfonate (552-02), a novel epithelial sodium channel blocker with potential clinical efficacy for cystic fibrosis lung disease by Hirsh, Andrew J, Zhang, Jim, Zamurs, Andra, Fleegle, Jacquelyn, Thelin, William R, Caldwell, Ray A, Sabater, Juan R, Abraham, William M, Donowitz, Mark, Cha, Boyoung, Johnson, Kevin B, St George, Judith A, Johnson, M Ross, Boucher, Richard C

“…Amiloride improves mucociliary clearance (MC) by blocking airway epithelial sodium channels (ENaC) and expanding airway surface liquid (ASL). However, the low…”
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