Search Results - "Zamurovic, Natasa"

Alternative Complement Pathway Inhibition Does Not Abrogate Meningococcal Killing by Serum of Vaccinated Individuals by Ispasanie, Emma, Muri, Lukas, Schubart, Anna, Thorburn, Christine, Zamurovic, Natasa, Holbro, Thomas, Kammüller, Michael, Pluschke, Gerd

“…Dysregulation of complement activation causes a number of diseases, including paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. These…”
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Alternative Complement Pathway Inhibition Abrogates Pneumococcal Opsonophagocytosis in Vaccine-Naïve, but Not in Vaccinated Individuals by Muri, Lukas, Ispasanie, Emma, Schubart, Anna, Thorburn, Christine, Zamurovic, Natasa, Holbro, Thomas, Kammüller, Michael, Pluschke, Gerd

“…To assess the relative contribution of opsonisation by antibodies, classical and alternative complement pathways to pneumococcal phagocytosis, we analyzed…”
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In vaccinated individuals serum bactericidal activity against B meningococci is abrogated by C5 inhibition but not by inhibition of the alternative complement pathway by Ispasanie, Emma, Muri, Lukas, Schmid, Marc, Schubart, Anna, Thorburn, Christine, Zamurovic, Natasa, Holbro, Thomas, Kammüller, Michael, Pluschke, Gerd

“…Several diseases caused by the dysregulation of complement activation can be treated with inhibitors of the complement components C5 and/or C3. However,…”
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Inhibition of the different complement pathways has varying impacts on the serum bactericidal activity and opsonophagocytosis against Haemophilus influenzae type b by Muri, Lukas, Schubart, Anna, Thorburn, Christine, Zamurovic, Natasa, Holbro, Thomas, Kammüller, Michael, Pluschke, Gerd, Ispasanie, Emma

“…Defense against type b (Hib) is dependent on antibodies and complement, which mediate both serum bactericidal activity (SBA) and opsonophagocytosis. Here we…”
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LTA4H inhibitor LYS006: Clinical PK/PD and safety in a randomized phase I clinical trial by Loesche, Christian, Picard, Damien, Van Hoorick, Benjamin, Schuhmann, Imelda, Jäger, Petra, Klein, Kai, Schuhler, Carole, Thoma, Gebhard, Markert, Christian, Poller, Birk, Zamurovic, Natasa, Weiss, H. Markus, Otto, Heike, Fink, Martin, Röhn, Till A.

“…LYS006 is a novel, highly potent and selective, new‐generation leukotriene A4 hydrolase (LTA4H) inhibitor in clinical development for the treatment of…”
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Phenobarbital mediates an epigenetic switch at the constitutive androstane receptor (CAR) target gene Cyp2b10 in the liver of B6C3F1 mice by Lempiäinen, Harri, Müller, Arne, Brasa, Sarah, Teo, Soon-Siong, Roloff, Tim-Christoph, Morawiec, Laurent, Zamurovic, Natasa, Vicart, Axel, Funhoff, Enrico, Couttet, Philippe, Schübeler, Dirk, Grenet, Olivier, Marlowe, Jennifer, Moggs, Jonathan, Terranova, Rémi

“…Evidence suggests that epigenetic perturbations are involved in the adverse effects associated with some drugs and toxicants, including certain classes of…”
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Human primary osteoclasts: in vitro generation and applications as pharmacological and clinical assay by Susa, Mira, Luong-Nguyen, Ngoc-Hong, Cappellen, David, Zamurovic, Natasa, Gamse, Rainer

“…Osteoclasts are cells of hematopoietic origin with a unique property of dissolving bone; their inhibition is a principle for treatment of diseases of bone…”
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Pharmacological Inhibition of MALT1 Protease Leads to a Progressive IPEX-Like Pathology by Martin, Kea, Junker, Ursula, Tritto, Elaine, Sutter, Esther, Rubic-Schneider, Tina, Morgan, Hannah, Niwa, Satoru, Li, Jianping, Schlapbach, Achim, Walker, Dana, Bigaud, Marc, Beerli, Christian, Littlewood-Evans, Amanda, Rudolph, Bettina, Laisney, Marc, Ledieu, David, Beltz, Karen, Quancard, Jean, Bornancin, Frédéric, Zamurovic Ribrioux, Natasa, Calzascia, Thomas

“…Genetic disruption or short-term pharmacological inhibition of MALT1 protease is effective in several preclinical models of autoimmunity and B cell…”
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Results of Preclinical Animal Studies to Evaluate the Effect of Iptacopan on Pregnancy-Related Outcomes by DeLise, Anthony, Zamurovic, Natasa, Hansen, Regine, Flandre, Thierry, Schmouder, Robert, Buono, Chiara

“…Introduction: Iptacopan is a first-in-class, oral, selective inhibitor of factor B, a key component of the complement system alternative pathway. Inhibition of…”
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Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation by Bornancin, Frédéric, Renner, Florian, Touil, Ratiba, Sic, Heiko, Kolb, Yeter, Touil-Allaoui, Ismahane, Rush, James S, Smith, Paul A, Bigaud, Marc, Junker-Walker, Ursula, Burkhart, Christoph, Dawson, Janet, Niwa, Satoru, Katopodis, Andreas, Nuesslein-Hildesheim, Barbara, Weckbecker, Gisbert, Zenke, Gerhard, Kinzel, Bernd, Traggiai, Elisabetta, Brenner, Dirk, Brüstle, Anne, St Paul, Michael, Zamurovic, Natasa, McCoy, Kathy D, Rolink, Antonius, Régnier, Catherine H, Mak, Tak W, Ohashi, Pamela S, Patel, Dhavalkumar D, Calzascia, Thomas

“…The paracaspase MALT1 plays an important role in immune receptor-driven signaling pathways leading to NF-κB activation. MALT1 promotes signaling by acting as a…”
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Coordinated activation of notch, Wnt, and transforming growth factor-beta signaling pathways in bone morphogenic protein 2-induced osteogenesis. Notch target gene Hey1 inhibits mineralization and Runx2 transcriptional activity by Zamurovic, Natasa, Cappellen, David, Rohner, Daisy, Susa, Mira

“…To examine early events in osteoblast differentiation, we analyzed the expression of about 9,400 genes in the murine MC3T3 cell line, whose robust…”
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Malt1 Protease Deficiency in Mice Disrupts Immune Homeostasis at Environmental Barriers and Drives Systemic T Cell-Mediated Autoimmunity by Martin, Kea, Touil, Ratiba, Kolb, Yeter, Cvijetic, Grozdan, Murakami, Kiichi, Israel, Laura, Duraes, Fernanda, Buffet, David, Glück, Anton, Niwa, Satoru, Bigaud, Marc, Junt, Tobias, Zamurovic, Natasa, Smith, Philip, McCoy, Kathy D, Ohashi, Pamela S, Bornancin, Frédéric, Calzascia, Thomas

“…The paracaspase Malt1 is a key regulator of canonical NF-κB activation downstream of multiple receptors in both immune and nonimmune cells. Genetic disruption…”
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Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice by Shimshek, Derya R., Jacobson, Laura H., Kolly, Carine, Zamurovic, Natasa, Balavenkatraman, Kamal Kumar, Morawiec, Laurent, Kreutzer, Robert, Schelle, Juliane, Jucker, Mathias, Bertschi, Barbara, Theil, Diethilde, Heier, Annabelle, Bigot, Karine, Beltz, Karen, Machauer, Rainer, Brzak, Irena, Perrot, Ludovic, Neumann, Ulf

“…Melanocytes of the hair follicle produce melanin and are essential in determining the differences in hair color. Pigment cell-specific MELanocyte Protein…”
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Ubiquitous overexpression of Hey1 transcription factor leads to osteopenia and chondrocyte hypertrophy in bone by Salie, Rishard, Kneissel, Michaela, Vukevic, Mirko, Zamurovic, Natasa, Kramer, Ina, Evans, Glenda, Gerwin, Nicole, Mueller, Matthias, Kinzel, Bernd, Susa, Mira

“…Abstract The transcription factor Hey1, a known Notch target gene of the HES family, has recently been described as a target gene of bone morphogenetic…”
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Identification of Dlk1-Dio3 imprinted gene cluster noncoding RNAs as novel candidate biomarkers for liver tumor promotion by Lempiäinen, Harri, Couttet, Philippe, Bolognani, Federico, Müller, Arne, Dubost, Valérie, Luisier, Raphaëlle, Del Rio Espinola, Alberto, Vitry, Veronique, Unterberger, Elif B, Thomson, John P, Treindl, Fridolin, Metzger, Ute, Wrzodek, Clemens, Hahne, Florian, Zollinger, Tulipan, Brasa, Sarah, Kalteis, Magdalena, Marcellin, Magali, Giudicelli, Fanny, Braeuning, Albert, Morawiec, Laurent, Zamurovic, Natasa, Längle, Ulrich, Scheer, Nico, Schübeler, Dirk, Goodman, Jay, Chibout, Salah-Dine, Marlowe, Jennifer, Theil, Diethilde, Heard, David J, Grenet, Olivier, Zell, Andreas, Templin, Markus F, Meehan, Richard R, Wolf, Roland C, Elcombe, Clifford R, Schwarz, Michael, Moulin, Pierre, Terranova, Rémi, Moggs, Jonathan G

“…The molecular events during nongenotoxic carcinogenesis and their temporal order are poorly understood but thought to include long-lasting perturbations of…”
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Identification of off-target binding proteins to elucidate mechanism of drug toxicity by Funhoff, Rico, Zamurovic, Natasa, Vicart, Axel, Bouchez, Laure, Voshol, Hans, Gerrits, Bertran, Guillemain, Gregory, Morawiec, Laurent, Gasser, Jean-Philippe

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Phenobarbital Mediates an Epigenetic Switch at the Constitutive Androstane Receptor by Lempiäinen, Harri, Müller, Arne, Brasa, Sarah, Teo, Soon-Siong, Roloff, Tim-Christoph, Morawiec, Laurent, Zamurovic, Natasa, Vicart, Axel, Funhoff, Enrico, Couttet, Philippe, Schübeler, Dirk, Grenet, Olivier, Marlowe, Jennifer, Moggs, Jonathan, Terranova, Rémi

“…Evidence suggests that epigenetic perturbations are involved in the adverse effects associated with some drugs and toxicants, including certain classes of…”
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Coordinated Activation of Notch, Wnt, and Transforming Growth Factor-β Signaling Pathways in Bone Morphogenic Protein 2-induced Osteogenesis by Zamurovic, Natasa, Cappellen, David, Rohner, Daisy, Susa, Mira

“…To examine early events in osteoblast differentiation, we analyzed the expression of about 9,400 genes in the murine MC3T3 cell line, whose robust…”
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Coordinated Activation of Notch, Wnt, and Transforming Growth Factor-β Signaling Pathways in Bone Morphogenic Protein 2-induced Osteogenesis by Natasa Zamurovic, David Cappellen, Daisy Rohner, Mira Susa

“…To examine early events in osteoblast differentiation, we analyzed the expression of about 9,400 genes in the murine MC3T3 cell line, whose robust…”
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Genome-wide analysis of DNA methylation profiles in a preclinical animal model of non-genotoxic carcinogenesis by Moggs, Jonathan, Teo, Soon Siong, Mueller, Arne, Morawiec, Laurent, Roloff, Tim, Heard, David, Staedtler, Frank, Schubeler, Dirk, Mohn, Fabian, Goodman, Jay, Phillips, Jennifer, Zamurovic, Natasa, Pognan, Francois, Chibout, Salah-Dine, Moulin, Pierre, Couttet, Philippe, Marlowe, Jennifer, Grenet, Olivier

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