Search Results - "Zampese, Enrico"

Disruption of mitochondrial complex I induces progressive parkinsonism by González-Rodríguez, Patricia, Zampese, Enrico, Stout, Kristen A., Guzman, Jaime N., Ilijic, Ema, Yang, Ben, Tkatch, Tatiana, Stavarache, Mihaela A., Wokosin, David L., Gao, Lin, Kaplitt, Michael G., López-Barneo, José, Schumacker, Paul T., Surmeier, D. James

“…Loss of functional mitochondrial complex I (MCI) in the dopaminergic neurons of the substantia nigra is a hallmark of Parkinson’s disease 1 . Yet, whether this…”
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Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease by Burbulla, Lena F., Song, Pingping, Mazzulli, Joseph R., Zampese, Enrico, Wong, Yvette C., Jeon, Sohee, Santos, David P., Blanz, Judith, Obermaier, Carolin D., Strojny, Chelsee, Savas, Jeffrey N., Kiskinis, Evangelos, Zhuang, Xiaoxi, Krüger, Rejko, Surmeier, D. James, Krainc, Dimitri

“…Mitochondrial and lysosomal dysfunction have been implicated in substantia nigra dopaminergic neurodegeneration in Parkinson’s disease (PD), but how these…”
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Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain by Graves, Steven M., Xie, Zhong, Stout, Kristen A., Zampese, Enrico, Burbulla, Lena F., Shih, Jean C., Kondapalli, Jyothisri, Patriarchi, Tommaso, Tian, Lin, Brichta, Lars, Greengard, Paul, Krainc, Dimitri, Schumacker, Paul T., Surmeier, D. James

“…Monoamine oxidase (MAO) metabolizes cytosolic dopamine (DA), thereby limiting auto-oxidation, but is also thought to generate cytosolic hydrogen peroxide (H 2…”
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Intracellular organelles in the saga of Ca2+ homeostasis: different molecules for different purposes? by Zampese, Enrico, Pizzo, Paola

“…An increase in the concentration of cytosolic free Ca 2+ is a key component regulating different cellular processes ranging from egg fertilization, active…”
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Calcium, Bioenergetics, and Parkinson's Disease by Zampese, Enrico, Surmeier, D James

“…Degeneration of substantia nigra (SN) dopaminergic (DAergic) neurons is responsible for the core motor deficits of Parkinson's disease (PD). These neurons are…”
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Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca²⁺ cross-talk by Zampese, Enrico, Fasolato, Cristina, Kipanyula, Maulilio J, Bortolozzi, Mario, Pozzan, Tullio, Pizzo, Paola

“…Presenilin mutations are the main cause of familial Alzheimer's disease (FAD). Presenilins also play a key role in Ca²⁺ homeostasis, and their FAD-linked…”
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α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson's disease by Geibl, Fanni F, Henrich, Martin T, Xie, Zhong, Zampese, Enrico, Ueda, Jun, Tkatch, Tatiana, Wokosin, David L, Nasiri, Elena, Grotmann, Constantin A, Dawson, Valina L, Dawson, Ted M, Chandel, Navdeep S, Oertel, Wolfgang H, Surmeier, D James

“…Pathological accumulation of aggregated α-synuclein (aSYN) is a common feature of Parkinson's disease (PD). However, the mechanisms by which intracellular aSYN…”
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Ca2+ channels couple spiking to mitochondrial metabolism in substantia nigra dopaminergic neurons by Zampese, Enrico, Wokosin, David L., Gonzalez-Rodriguez, Patricia, Guzman, Jaime N., Tkatch, Tatiana, Kondapalli, Jyothisri, Surmeier, William C., D’Alessandro, Karis B., De Stefani, Diego, Rizzuto, Rosario, Iino, Masamitsu, Molkentin, Jeffery D., Chandel, Navdeep S., Schumacker, Paul T., Surmeier, D. James

“…How do neurons match generation of adenosine triphosphate by mitochondria to the bioenergetic demands of regenerative activity? Although the subject of…”
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Author Correction: Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain by Graves, Steven M., Xie, Zhong, Stout, Kristen A., Zampese, Enrico, Burbulla, Lena F., Shih, Jean C., Kondapalli, Jyothisri, Patriarchi, Tommaso, Tian, Lin, Brichta, Lars, Greengard, Paul, Krainc, Dimitri, Schumacker, Paul T., Surmeier, D. James

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Presenilin‐2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake by Brunello, Lucia, Zampese, Enrico, Florean, Cristina, Pozzan, Tullio, Pizzo, Paola, Fasolato, Cristina

“…We have previously shown that familial Alzheimer’s disease mutants of presenilin‐2 (PS2) and, to a lesser extent, of presenilin‐1 (PS1) lower the Ca2+…”
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GENETIC DISRUPTION OF MITOCHONDRIAL COMPLEX I TRIGGERS PROGRESSIVE, LEVODOPA-RESPONSIVE PARKINSONISM WITH NIGRAL DETERMINANTS by Tassigny, Xavier D‘Anglemont De, Zampese, Enrico, Chandel, Navdeep, Barneo, José López, Surmeier, Dalton, Rodriguez, Patricia Gonzalez

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Transient Activation of GABAB Receptors Suppresses SK Channel Currents in Substantia Nigra Pars Compacta Dopaminergic Neurons by Estep, Chad M, Galtieri, Daniel J, Zampese, Enrico, Goldberg, Joshua A, Brichta, Lars, Greengard, Paul, Surmeier, D James

“…Dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) are richly innervated by GABAergic neurons. The postsynaptic effects of GABA on SNc DA…”
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Presenilin-2 modulation of ER-mitochondria interactions: FAD mutations, mechanisms and pathological consequences by Zampese, Enrico, Fasolato, Cristina, Pozzan, Tullio, Pizzo, Paola

“…Presenilin (PS) mutations are the main cause of Familial Alzheimer's Disease (FAD), and have been demonstrated to cause an imbalance of intracellular Ca 2+…”
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Mitochondria: the calcium connection by Contreras, Laura, Drago, Ilaria, Zampese, Enrico, Pozzan, Tullio

“…Calcium handling by mitochondria is a key feature in cell life. It is involved in energy production for cell activity, in buffering and shaping cytosolic…”
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Calcium and Parkinson's disease by Surmeier, D. James, Schumacker, Paul T., Guzman, Jaime D., Ilijic, Ema, Yang, Ben, Zampese, Enrico

“…Parkinson's disease (PD) is the second most common neurodegenerative disease in the world. Its causes are poorly understood and there is no proven therapeutic…”
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Intracellular organelles in the saga of Ca^sup 2+^ homeostasis: different molecules for different purposes? by Zampese, Enrico, Pizzo, Paola

“…An increase in the concentration of cytosolic free Ca^sup 2+^ is a key component regulating different cellular processes ranging from egg fertilization, active…”
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Selective neuronal vulnerability in Parkinson's disease by Gonzalez-Rodriguez, Patricia, Zampese, Enrico, Surmeier, D James

“…Parkinson's disease (PD) is the second most common neurodegenerative disease, disabling millions worldwide. Despite the imperative PD poses, at present, there…”
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Disease mechanisms as Subtypes: Mitochondrial and bioenergetic dysfunction by Gonzalez-Rodriguez, Patricia, Zampese, Enrico, Surmeier, D James

“…Parkinson disease (PD) is the second most common neurodegenerative disease in the world. Despite its enormous human and societal cost, there is no…”
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Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson's disease by Geibl, Fanni F, Henrich, Ma, Xie, Zhong, Zampese, Enrico, Ueda, Jun, Tkatch, Tatiana, Wokosin, David L, Nasiri, Elena, Grotmann, Constantin A, Dawson, Valina L, Dawson, Ted M, Chandel, Navdeep S, Oertel, Wolfgang H, Surmeier, D. James

“…Background Pathological accumulation of aggregated [alpha]-synuclein (aSYN) is a common feature of Parkinson's disease (PD). However, the mechanisms by which…”
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Author Correction: Disruption of mitochondrial complex I induces progressive parkinsonism by González-Rodríguez, Patricia, Zampese, Enrico, Stout, Kristen A., Guzman, Jaime N., Ilijic, Ema, Yang, Ben, Tkatch, Tatiana, Stavarache, Mihaela A., Wokosin, David L., Gao, Lin, Kaplitt, Michael G., López-Barneo, José, Schumacker, Paul T., Surmeier, D. James

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