Improving the Waiting List by Using 75-Year-Old Donors for Recipients With Hepatocellular Carcinoma

Abstract The best treatment for hepatocellular carcinoma (HCC) associated with liver cirrhosis is liver transplantation and the best results are obtained when the tumors fulfill the Milan criteria. However, although the number of transplants is increasing, the organ deficit is growing, which lengthe...

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Bibliographic Details
Published in:	Transplantation proceedings Vol. 42; no. 2; pp. 627 - 630
Main Authors:	Cascales Campos, P.A, Romero, P.R, Gonzalez, R, Zambudio, A.R, Martinez Frutos, I.M, de la Peña, J, Bueno, F.S, Robles Campos, R, Miras, M, Pons Miñano, J.A, Sanmartin Monzo, A, Domingo, J, Bixquert Montagud, V, Parrilla Paricio, P
Format:	Journal Article Conference Proceeding
Language:	English
Published:	Amsterdam Elsevier Inc 01-03-2010 Elsevier
Subjects:	Age Factors Aged Aged, 80 and over Biological and medical sciences Brain Death Carcinoma, Hepatocellular - complications Carcinoma, Hepatocellular - surgery Female Fundamental and applied biological sciences. Psychology Fundamental immunology Gastroenterology. Liver. Pancreas. Abdomen Humans Liver Cirrhosis - complications Liver Cirrhosis - surgery Liver Neoplasms - complications Liver Neoplasms - surgery Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Patient Selection Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue Donors Tissue, organ and graft immunology Tumors Waiting Lists Suboptimal donor Human Hepatic disease Hepatocellular carcinoma Recipient Transplantation Malignant tumor Medicine Liver cancer Improvement Treatment Surgery Digestive diseases Graft Waiting list Cancer
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Summary:	Abstract The best treatment for hepatocellular carcinoma (HCC) associated with liver cirrhosis is liver transplantation and the best results are obtained when the tumors fulfill the Milan criteria. However, although the number of transplants is increasing, the organ deficit is growing, which lengthens time on the waiting list, increasing the risk of tumor progression of and exclusion from the list. The use of elderly donors is a valid option for patients on the transplant waiting list with HCC, reducing time on the waiting list. We report our experience with patients transplanted for HCC associated with hepatic cirrhosis using livers from donors >75 years of age. Our preliminary results supported the use of elderly suboptimal donors making it possible to give priority to these patients. All patients in the series achieved good graft function after a follow-up of 2 years with a 100% disease-free survival rate. More extensive long-term studies are needed to confirm these findings.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0041-1345 1873-2623
DOI:	10.1016/j.transproceed.2010.02.015