Local administration of curcumin-loaded nanoparticles effectively inhibits inflammation and bone resorption associated with experimental periodontal disease

Local administration of curcumin-loaded nanoparticles effectively inhibits inflammation and bone resorption associated with experimental periodontal disease

There is evidence indicating that curcumin has multiple biological activities, including anti-inflammatory properties. In vitro and in vivo studies demonstrate that curcumin may attenuate inflammation and the connective tissue destruction associated with periodontal disease. Most of these studies us...

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Bibliographic Details
Published in:Scientific reports Vol. 8; no. 1; pp. 6652 - 11
Main Authors: Zambrano, Laura M. G., Brandao, Dayane A., Rocha, Fernanda R. G., Marsiglio, Raquel P., Longo, Ieda B., Primo, Fernando L., Tedesco, Antonio C., Guimaraes-Stabili, Morgana R., Rossa Junior, Carlos
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 27-04-2018
Nature Publishing Group
Subjects:
38
38/1
59/78
631/1647/350/354
692/699/3020/3029
Anti-inflammatory agents
Biological effects
Bone resorption
Curcumin
Gum disease
Humanities and Social Sciences
Inflammation
Lipopolysaccharides
MAP kinase
multidisciplinary
Nanoparticles
NF-κB protein
Periodontal diseases
Periodontics
Pharmacodynamics
Science
Science (multidisciplinary)
Vitamin D
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Summary:There is evidence indicating that curcumin has multiple biological activities, including anti-inflammatory properties. In vitro and in vivo studies demonstrate that curcumin may attenuate inflammation and the connective tissue destruction associated with periodontal disease. Most of these studies use systemic administration, and considering the site-specific nature of periodontal disease and also the poor pharmacodynamic properties of curcumin, we conducted this proof of principle study to assess the biological effect of the local administration of curcumin in a nanoparticle vehicle on experimental periodontal disease. We used 16 rats divided into two groups of 8 animals according to the induction of experimental periodontal disease by bilateral injections of LPS or of the vehicle control directly into the gingival tissues 3×/week for 4 weeks. The same volume of curcumin-loaded nanoparticles or of nanoparticle vehicle was injected into the same sites 2×/week. µCT analysis showed that local administration of curcumin resulted in a complete inhibition of inflammatory bone resorption and in a significant decrease of both osteoclast counts and of the inflammatory infiltrate; as well as a marked attenuation of p38 MAPK and NF-kB activation. We conclude that local administration of curcumin-loaded nanoparticles effectively inhibited inflammation and bone resorption associated with experimental periodontal disease.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-24866-2