Search Results - "Zamboni, Robert J."

Pathogenic mitochondrial dysfunction and metabolic abnormalities by Moos, Walter H., Faller, Douglas V., Glavas, Ioannis P., Harpp, David N., Kamperi, Natalia, Kanara, Iphigenia, Kodukula, Krishna, Mavrakis, Anastasios N., Pernokas, Julie, Pernokas, Mark, Pinkert, Carl A., Powers, Whitney R., Steliou, Kosta, Tamvakopoulos, Constantin, Vavvas, Demetrios G., Zamboni, Robert J., Sampani, Konstantina

“…Metabolic commonalities are found in a wide range of diseases, acquired or inherited, with mitochondria playing key roles in all of them. [Display omitted]…”
Get full text

Treatment and prevention of pathological mitochondrial dysfunction in retinal degeneration and in photoreceptor injury by Moos, Walter H., Faller, Douglas V., Glavas, Ioannis P., Harpp, David N., Kamperi, Natalia, Kanara, Iphigenia, Kodukula, Krishna, Mavrakis, Anastasios N., Pernokas, Julie, Pernokas, Mark, Pinkert, Carl A., Powers, Whitney R., Sampani, Konstantina, Steliou, Kosta, Tamvakopoulos, Constantin, Vavvas, Demetrios G., Zamboni, Robert J., Chen, Xiaohong

“…Insidious cascade of converging pathways involving oxidative stress, altered lipid metabolism, and mitochondrial injury, leading to adverse ophthalmic…”
Get full text

Practical Route to a New Class of LTD4 Receptor Antagonists by Larsen, Robert D, Corley, Edward G, King, Anthony O, Carroll, James D, Davis, Paul, Verhoeven, Thomas R, Reider, Paul J, Labelle, Marc, Gauthier, Jacques Y, Xiang, Yi Bin, Zamboni, Robert J

“…A general approach to the synthesis of a new class of LTD4 antagonists is presented. The key diarylpropane framework was prepared by Claisen−Schmidt…”
Get full text

Structure-activity relationship studies on ortho-substituted cinnamic acids, a new class of selective EP3 antagonists by BELLEY, Michel, GALLANT, Michel, TREMBLAY, Nathalie, LAMONTAGNE, Sonia, CARRIERE, Marie-Claude, DENIS, Danielle, GREIG, Gillian M, SLIPETZ, Deborah, METTERS, Kathleen M, GORDON, Robert, CHI CHUNG CHAN, ZAMBONI, Robert J, ROY, Bruno, HOUDE, Karine, LACHANCE, Nicolas, LABELLE, Marc, TRIMBLE, Laird A, CHAURET, Nathalie, CHUN LI, SAWYER, Nicole

Get full text

Epigenetic treatment of dermatologic disorders by Moos, Walter H., Faller, Douglas V., Glavas, Ioannis P., Harpp, David N., Kanara, Iphigenia, Pinkert, Carl A., Powers, Whitney R., Sampani, Konstantina, Steliou, Kosta, Vavvas, Demetrios G., Kodukula, Krishna, Zamboni, Robert J.

“…Healthy skin protects us against a multitude of insults, but injured or maladapted skin can lead to infection, inflammation, or worse. Fortunately, naturally…”
Get full text

Base-catalyzed deuterium and tritium labeling of aryl methyl sulfones by Scheigetz, John, Berthelette, Carl, Li, Chun, Zamboni, Robert J.

“…A method is presented for conveniently tritiating the aryl methyl sulfones of compounds identified as potent and selective inhibitors of human Cox‐2 and as DP…”
Get full text

Klotho Pathways, Myelination Disorders, Neurodegenerative Diseases, and Epigenetic Drugs by Moos, Walter H, Faller, Douglas V, Glavas, Ioannis P, Harpp, David N, Kanara, Iphigenia, Mavrakis, Anastasios N, Pernokas, Julie, Pernokas, Mark, Pinkert, Carl A, Powers, Whitney R, Sampani, Konstantina, Steliou, Kosta, Vavvas, Demetrios G, Zamboni, Robert J, Kodukula, Krishna, Chen, Xiaohong

“…In this review we outline a rationale for identifying neuroprotectants aimed at inducing endogenous Klotho activity and expression, which is epigenetic action,…”
Get full text

Comparison between two classes of selective EP3 antagonists and their biological activities by BELLEY, Michel, CHI CHUNG CHAN, LAMONTAGNE, Sonia, CARRIERE, Marie-Claude, DENIS, Danielle, GREIG, Gillian M, SLIPETZ, Deborah, GORDON, Robert, CHAURET, Nathalie, CHUN LI, ZAMBONI, Robert J, METTERS, Kathleen M, GAREAU, Yves, GALLANT, Michel, JUTEAU, Hélène, HOUDE, Karine, LACHANCE, Nicolas, LABELLE, Marc, SAWYER, Nicole, TREMBLAY, Nathalie

Get full text

Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors by Han, Yongxin, Giroux, André, Colucci, John, Bayly, Christopher I., Mckay, Daniel J., Roy, Sophie, Xanthoudakis, Steve, Vaillancourt, John, Rasper, Dita M., Tam, John, Tawa, Paul, Nicholson, Donald W., Zamboni, Robert J.

“…The discovery of a class of potent, selective and reversible non-peptidic caspase-3 inhibitors (e.g., M867) is described. The iterative process for the…”
Get full text

Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones by Isabel, Elise, Aspiotis, Renee, Black, W. Cameron, Colucci, John, Fortin, Réjean, Giroux, André, Grimm, Erich L., Han, Yongxin, Mellon, Christophe, Nicholson, Donald W., Rasper, Dita M., Renaud, Johanne, Roy, Sophie, Tam, John, Tawa, Paul, Vaillancourt, John P., Xanthoudakis, Steven, Zamboni, Robert J.

“…Caspase-3 is a cysteinyl protease that mediates apoptotic cell death. Its inhibition may have an important impact on the treatment of several degenerative…”
Get full text

Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors by Han, Yongxin, Giroux, André, Grimm, Erich L., Aspiotis, Renée, Francoeur, Sébastien, Bayly, Christopher I., Mckay, Daniel J., Roy, Sophie, Xanthoudakis, Steve, Vaillancourt, John P., Rasper, Dita M., Tam, John, Tawa, Paul, Thornberry, Nancy A., Paterson, Erin P., Garcia-Calvo, Margarita, Becker, Joseph W., Rotonda, Jennifer, Nicholson, Donald W., Zamboni, Robert J.

“…The discovery of a series of potent, selective and reversible dipeptidyl caspase-3 inhibitors are reported. The iterative discovery process of using…”
Get full text

Solid phase synthesis of selective caspase-3 peptide inhibitors by GRIMM, Erich L, ROY, Bruno, VAILLANCOURT, John P, XANTHOUDAKIS, Steven, ZAMBONI, Robert J, ASPIOTIS, Renee, BAYLY, Christopher I, NICHOLSON, Donald W, RASPER, Dita M, RENAUD, Johanne, ROY, Sophie, TAM, John, TAWA, Paul

“…A robust method for the solid phase synthesis of a series of selective caspase-3 peptide inhibitors is described. The inhibitors can be obtained after cleavage…”
Get full text

Synthesis and characterization of tritium labeled 2,3,4,9-tetrahydro-1H-carbazoles as potent DP receptor antagonists by Berthelette, Carl, Boyd, Michael J., Lachance, Nicolas, Roy, Bruno, Sturino, Claudio F., Scheigetz, John, Zamboni, Robert J.

“…Tritium labeled 2,3,4,9‐tetrahydro‐1H‐carbazole 1a and 2a were prepared in good yields with a specific activity of 7.0 Ci/mmol (214 GBq/mmol) and 4.2 Ci/mmol…”
Get full text

Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation by Gervais, François G., Xu, Daigen, Robertson, George S., Vaillancourt, John P., Zhu, Yanxia, Huang, JingQi, LeBlanc, Andréa, Smith, David, Rigby, Michael, Shearman, Mark S., Clarke, Earl E., Zheng, Hui, Van Der Ploeg, Leonardus H.T., Ruffolo, Salvatore C., Thornberry, Nancy A., Xanthoudakis, Steve, Zamboni, Robert J., Roy, Sophie, Nicholson, Donald W.

“…The amyloid-β precursor protein (APP) is directly and efficiently cleaved by caspases during apoptosis, resulting in elevated amyloid-β (Aβ) peptide formation…”
Get full text

Purification of human leukotriene C4 synthase from dimethylsulfoxide‐differentiated U937 cells by NICHOLSON, Donald W., KLEMBA, Michael W., RASPER, Dita M., METTERS, Kathleen M., ZAMBONI, Robert J., FORD‐HUTCHINSON, Anthony W.

“…Human leukotriene C4 (LTC4) synthase was purified > 10000‐fold from dimethylsulfoxide‐differentiated U937 cells. Steps included: (a) solubilization of…”
Get full text

Comparison between two classes of selective EP sub(3) antagonists and their biological activities by Belley, Michel, Chan, Chi Chung, Gareau, Yves, Gallant, Michel, Juteau, Helene, Houde, Karine, Lachance, Nicolas, Labelle, Marc, Sawyer, Nicole, Tremblay, Nathalie, Lamontagne, Sonia, Carriere, Marie-Claude, Denis, Danielle, Greig, Gillian M, Slipetz, Deborah, Gordon, Robert, Chauret, Nathalie, Li, Chun, Zamboni, Robert J, Metters, Kathleen M

“…Two different series of very potent and selective EP sub(3) antagonists have been reported: a novel series of ortho-substituted cinnamic acids [Belley, M.,…”
Get full text

Comparison between two classes of selective EP(3) antagonists and their biological activities by Belley, Michel, Chan, Chi Chung, Gareau, Yves, Gallant, Michel, Juteau, Hélène, Houde, Karine, Lachance, Nicolas, Labelle, Marc, Sawyer, Nicole, Tremblay, Nathalie, Lamontagne, Sonia, Carrière, Marie-Claude, Denis, Danielle, Greig, Gillian M, Slipetz, Deborah, Gordon, Robert, Chauret, Nathalie, Li, Chun, Zamboni, Robert J, Metters, Kathleen M

“…Two different series of very potent and selective EP(3) antagonists have been reported: a novel series of ortho-substituted cinnamic acids [Belley, M.,…”
Get full text

Comparison between two classes of selective EP 3 antagonists and their biological activities by Belley, Michel, Chan, Chi Chung, Gareau, Yves, Gallant, Michel, Juteau, Hélène, Houde, Karine, Lachance, Nicolas, Labelle, Marc, Sawyer, Nicole, Tremblay, Nathalie, Lamontagne, Sonia, Carrière, Marie-Claude, Denis, Danielle, Greig, Gillian M., Slipetz, Deborah, Gordon, Robert, Chauret, Nathalie, Li, Chun, Zamboni, Robert J., Metters, Kathleen M.

“…The structural differences and their effects on the biological activity in vivo, in vitro and metabolism have been analyzed. Two different series of very…”
Get full text

Structure-activity relationship studies on ortho-substituted cinnamic acids, a new class of selective EP(3) antagonists by Belley, Michel, Gallant, Michel, Roy, Bruno, Houde, Karine, Lachance, Nicolas, Labelle, Marc, Trimble, Laird A, Chauret, Nathalie, Li, Chun, Sawyer, Nicole, Tremblay, Nathalie, Lamontagne, Sonia, Carrière, Marie-Claude, Denis, Danielle, Greig, Gillian M, Slipetz, Deborah, Metters, Kathleen M, Gordon, Robert, Chan, Chi Chung, Zamboni, Robert J

“…A series of novel ortho-substituted cinnamic acids have been synthesized, and their binding activity and selectivity on the four prostaglandin E(2) receptors…”
Get full text

Structure–activity relationship studies on ortho-substituted cinnamic acids, a new class of selective EP 3 antagonists by Belley, Michel, Gallant, Michel, Roy, Bruno, Houde, Karine, Lachance, Nicolas, Labelle, Marc, Trimble, Laird A., Chauret, Nathalie, Li, Chun, Sawyer, Nicole, Tremblay, Nathalie, Lamontagne, Sonia, Carrière, Marie-Claude, Denis, Danielle, Greig, Gillian M., Slipetz, Deborah, Metters, Kathleen M., Gordon, Robert, Chan, Chi Chung, Zamboni, Robert J.

“…The synthesis, biological activity and the metabolism in vitro of a novel series of EP 3 antagonists have been evaluated. The very potent and selective EP 2…”
Get full text