Search Results - "Zambon, Alexander C."

GO-Elite: a flexible solution for pathway and ontology over-representation by ZAMBON, Alexander C, GAJ, Stan, HO, Isaac, HANSPERS, Kristina, VRANIZAN, Karen, EVELO, Chris T, CONKLIN, Bruce R, PICO, Alexander R, SALOMONIS, Nathan

“…We introduce GO-Elite, a flexible and powerful pathway analysis tool for a wide array of species, identifiers (IDs), pathways, ontologies and gene sets. In…”
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HIF1α Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes by Guimarães-Camboa, Nuno, Stowe, Jennifer, Aneas, Ivy, Sakabe, Noboru, Cattaneo, Paola, Henderson, Lindsay, Kilberg, Michael S., Johnson, Randall S., Chen, Ju, McCulloch, Andrew D., Nobrega, Marcelo A., Evans, Sylvia M., Zambon, Alexander C.

“…Transcriptional mediators of cell stress pathways, including HIF1α, ATF4, and p53, are key to normal development and play critical roles in disease, including…”
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Prominin‐1 controls stem cell activation by orchestrating ciliary dynamics by Singer, Donald, Thamm, Kristina, Zhuang, Heng, Karbanová, Jana, Gao, Yan, Walker, Jemma Victoria, Jin, Heng, Wu, Xiangnan, Coveney, Clarissa R, Marangoni, Pauline, Lu, Dongmei, Grayson, Portia Rebecca Clare, Gulsen, Tulay, Liu, Karen J, Ardu, Stefano, Wann, Angus KT, Luo, Shouqing, Zambon, Alexander C, Jetten, Anton M, Tredwin, Christopher, Klein, Ophir D, Attanasio, Massimo, Carmeliet, Peter, Huttner, Wieland B, Corbeil, Denis, Hu, Bing

“…Proper temporal and spatial activation of stem cells relies on highly coordinated cell signaling. The primary cilium is the sensory organelle that is…”
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Transcription factor ISL1 is essential for pacemaker development and function by Liang, Xingqun, Zhang, Qingquan, Cattaneo, Paola, Zhuang, Shaowei, Gong, Xiaohui, Spann, Nathanael J, Jiang, Cizhong, Cao, Xinkai, Zhao, Xiaodong, Zhang, Xiaoli, Bu, Lei, Wang, Gang, Chen, H S Vincent, Zhuang, Tao, Yan, Jie, Geng, Peng, Luo, Lina, Banerjee, Indroneal, Chen, Yihan, Glass, Christopher K, Zambon, Alexander C, Chen, Ju, Sun, Yunfu, Evans, Sylvia M

“…The sinoatrial node (SAN) maintains a rhythmic heartbeat; therefore, a better understanding of factors that drive SAN development and function is crucial to…”
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Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation by Walker, Jemma Victoria, Zhuang, Heng, Singer, Donald, Illsley, Charlotte Sara, Kok, Wai Ling, Sivaraj, Kishor K., Gao, Yan, Bolton, Chloe, Liu, Yuying, Zhao, Mengyuan, Grayson, Portia Rebecca Clare, Wang, Shuang, Karbanová, Jana, Lee, Tim, Ardu, Stefano, Lai, Qingguo, Liu, Jihui, Kassem, Moustapha, Chen, Shuo, Yang, Kai, Bai, Yuxing, Tredwin, Christopher, Zambon, Alexander C., Corbeil, Denis, Adams, Ralf, Abdallah, Basem M., Hu, Bing

“…Stem cells (SCs) receive inductive cues from the surrounding microenvironment and cells. Limited molecular evidence has connected tissue-specific mesenchymal…”
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GenMAPP 2: new features and resources for pathway analysis by Salomonis, Nathan, Hanspers, Kristina, Zambon, Alexander C, Vranizan, Karen, Lawlor, Steven C, Dahlquist, Kam D, Doniger, Scott W, Stuart, Josh, Conklin, Bruce R, Pico, Alexander R

“…Microarray technologies have evolved rapidly, enabling biologists to quantify genome-wide levels of gene expression, alternative splicing, and sequence…”
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Alternative splicing regulates mouse embryonic stem cell pluripotency and differentiation by Salomonis, Nathan, Schlieve, Christopher R, Pereira, Laura, Wahlquist, Christine, Colas, Alexandre, Zambon, Alexander C, Vranizan, Karen, Spindler, Matthew J, Pico, Alexander R, Cline, Melissa S, Clark, Tyson A, Williams, Alan, Blume, John E, Samal, Eva, Mercola, Mark, Merrill, Bradley J, Conklin, Bruce R

“…Two major goals of regenerative medicine are to reproducibly transform adult somatic cells into a pluripotent state and to control their differentiation into…”
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G Protein-Coupled Receptor (GPCR) Expression in Native Cells: "Novel" endoGPCRs as Physiologic Regulators and Therapeutic Targets by Insel, Paul A, Wilderman, Andrea, Zambon, Alexander C, Snead, Aaron N, Murray, Fiona, Aroonsakool, Nakon, McDonald, Daniel S, Zhou, Shu, McCann, Thalia, Zhang, Lingzhi, Sriram, Krishna, Chinn, Amy M, Michkov, Alexander V, Lynch, Rebecca M, Overland, Aaron C, Corriden, Ross

“…G protein-coupled receptors (GPCRs), the largest family of signaling receptors in the human genome, are also the largest class of targets of approved drugs…”
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Use of the Ki67 promoter to label cell cycle entry in living cells by Zambon, Alexander C

“…Genetic based reporters have distinct advantages over classical immunocytochemical techniques for probing cellular functions. Most importantly, they enable…”
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Brain Endothelial Erythrophagocytosis and Hemoglobin Transmigration Across Brain Endothelium: Implications for Pathogenesis of Cerebral Microbleeds by Chang, Rudy, Castillo, Juan, Zambon, Alexander C, Krasieva, Tatiana B, Fisher, Mark J, Sumbria, Rachita K

“…Peripheral endothelial cells are capable of erythrophagocytosis, but data on brain endothelial erythrophagocytosis are limited. We studied the relationship…”
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Effects of (−)-Epicatechin on Myocardial Infarct Size and Left Ventricular Remodeling After Permanent Coronary Occlusion by Yamazaki, Katrina Go, PhD, Taub, Pam R., MD, Barraza-Hidalgo, Maraliz, BS, Rivas, Maria M., BS, Zambon, Alexander C., PhD, Ceballos, Guillermo, MD, PhD, Villarreal, Francisco J., MD, PhD

“…Objectives We examined the effects of the flavanol (−)-epicatechin on short- and long-term infarct size and left ventricular (LV) structure and function after…”
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Classic "broken cell" techniques and newer live cell methods for cell cycle assessment by Henderson, Lindsay, Bortone, Dante S, Lim, Curtis, Zambon, Alexander C

“…Many common, important diseases are either caused or exacerbated by hyperactivation (e.g., cancer) or inactivation (e.g., heart failure) of the cell division…”
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Acute and Chronic Dosing of a High-Affinity Rat/Mouse Chimeric Transferrin Receptor Antibody in Mice by Castellanos, Demi M, Sun, Jiahong, Yang, Joshua, Ou, Weijun, Zambon, Alexander C, Pardridge, William M, Sumbria, Rachita K

“…Non-invasive brain delivery of neurotherapeutics is challenging due to the blood-brain barrier. The revived interest in transferrin receptor antibodies…”
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Synthesis and pharmacological characterization of ethylenediamine synthetic opioids in human μ‐opiate receptor 1 (OPRM1) expressing cells by Hsu, Tom, Mallareddy, Jayapal R., Yoshida, Kayla, Bustamante, Vincent, Lee, Tim, Krstenansky, John L., Zambon, Alexander C.

“…Opioids are powerful analgesics acting via the human μ‐opiate receptor (hMOR). Opioid use is associated with adverse effects such as tolerance, addiction,…”
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Gene Expression Patterns Define Key Transcriptional Events in Cell-Cycle Regulation by cAMP and Protein Kinase A by Zambon, Alexander C., Zhang, Lingzhi, Minovitsky, Simon, Kanter, Joan R., Prabhakar, Shyam, Salomonis, Nathan, Vranizan, Karen, Dubchak, Inna, Conklin, Bruce R., Insel, Paul A., Taylor, Susan S.

“…Although a substantial number of hormones and drugs increase cellular cAMP levels, the global impact of cAMP and its major effector mechanism, protein kinase A…”
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Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis by Moore-Morris, Thomas, Guimarães-Camboa, Nuno, Banerjee, Indroneal, Zambon, Alexander C, Kisseleva, Tatiana, Velayoudon, Aurélie, Stallcup, William B, Gu, Yusu, Dalton, Nancy D, Cedenilla, Marta, Gomez-Amaro, Rafael, Zhou, Bin, Brenner, David A, Peterson, Kirk L, Chen, Ju, Evans, Sylvia M

“…Activation and accumulation of cardiac fibroblasts, which result in excessive extracellular matrix deposition and consequent mechanical stiffness, myocyte…”
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Elimination of proliferating cells from CNS grafts using a Ki67 promoter-driven thymidine kinase by Tieng, Vannary, Cherpin, Ophelie, Gutzwiller, Eveline, Zambon, Alexander C, Delgado, Christophe, Salmon, Patrick, Dubois-Dauphin, Michel, Krause, Karl-Heinz

“…Pluripotent stem cell (PSC)-based cell therapy is an attractive concept for neurodegenerative diseases, but can lead to tumor formation. This is particularly…”
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Ca2+/Calmodulin-Dependent Protein Kinase II δ Mediates Myocardial Ischemia/Reperfusion Injury Through Nuclear Factor-κB by Ling, Haiyun, Gray, Charles B.B, Zambon, Alexander C, Grimm, Michael, Gu, Yusu, Dalton, Nancy, Purcell, Nicole H, Peterson, Kirk, Brown, Joan Heller

“…RATIONALE:Ca/calmodulin-dependent protein kinase II (CaMKII) has been implicated as a maladaptive mediator of cardiac ischemic injury. We hypothesized that the…”
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Differential sensitivity to longitudinal and transverse stretch mediates transcriptional responses in mouse neonatal ventricular myocytes by Cao, Shulin, Buchholz, Kyle S, Tan, Philip, Stowe, Jennifer C, Wang, Ariel, Fowler, Annabelle, Knaus, Katherine R, Khalilimeybodi, Ali, Zambon, Alexander C, Omens, Jeffrey H, Saucerman, Jeffrey J, McCulloch, Andrew D

“…To identify how cardiomyocyte mechanosensitive signaling pathways are regulated by anisotropic stretch, micropatterned mouse neonatal cardiomyocytes were…”
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Mechanosensitive Kinases Regulate Stiffness-Induced Cardiomyocyte Maturation by Young, Jennifer L., Kretchmer, Kyle, Ondeck, Matthew G., Zambon, Alexander C., Engler, Adam J.

“…Cells secrete and assemble extracellular matrix throughout development, giving rise to time-dependent, tissue-specific stiffness. Mimicking myocardial matrix…”
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