Search Results - "Zambetti, A."

ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth by Remsberg, Jarrett R., Suciu, Radu M., Zambetti, Noemi A., Hanigan, Thomas W., Firestone, Ari J., Inguva, Anagha, Long, Amanda, Ngo, Nhi, Lum, Kenneth M., Henry, Cassandra L., Richardson, Stewart K., Predovic, Marina, Huang, Ben, Dix, Melissa M., Howell, Amy R., Niphakis, Micah J., Shannon, Kevin, Cravatt, Benjamin F.

“…Multiple Ras proteins, including N-Ras, depend on a palmitoylation/depalmitoylation cycle to regulate their subcellular trafficking and oncogenicity. General…”
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Deficiency of the ribosome biogenesis gene Sbds in hematopoietic stem and progenitor cells causes neutropenia in mice by attenuating lineage progression in myelocytes by Zambetti, Noemi A, Bindels, Eric M J, Van Strien, Paulina M H, Valkhof, Marijke G, Adisty, Maria N, Hoogenboezem, Remco M, Sanders, Mathijs A, Rommens, Johanna M, Touw, Ivo P, Raaijmakers, Marc H G P

“…Shwachman-Diamond syndrome is a congenital bone marrow failure disorder characterized by debilitating neutropenia. The disease is associated with…”
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Massive parallel RNA sequencing of highly purified mesenchymal elements in low-risk MDS reveals tissue-context-dependent activation of inflammatory programs by Chen, S, Zambetti, N A, Bindels, E M J, Kenswill, K, Mylona, A M, Adisty, N M, Hoogenboezem, R M, Sanders, M A, Cremers, E M P, Westers, T M, Jansen, J H, van de Loosdrecht, A A, Raaijmakers, M H G P

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Attention to novel and target stimuli in trauma survivors by Kimble, Matthew O, Fleming, Kevin, Bandy, Carole, Zambetti, A

“…Abstract Trauma and its consequences can have lasting biological and cognitive effects on those who experience them. This study investigated the extent to…”
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Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia by Zambetti, Noemi A., Ping, Zhen, Chen, Si, Kenswil, Keane J.G., Mylona, Maria A., Sanders, Mathijs A., Hoogenboezem, Remco M., Bindels, Eric M.J., Adisty, Maria N., Van Strien, Paulina M.H., van der Leije, Cindy S., Westers, Theresia M., Cremers, Eline M.P., Milanese, Chiara, Mastroberardino, Pier G., van Leeuwen, Johannes P.T.M., van der Eerden, Bram C.J., Touw, Ivo P., Kuijpers, Taco W., Kanaar, Roland, van de Loosdrecht, Arjan A., Vogl, Thomas, Raaijmakers, Marc H.G.P.

“…Mesenchymal niche cells may drive tissue failure and malignant transformation in the hematopoietic system, but the underlying molecular mechanisms and…”
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'Selectin' endothelium to protect blood stem cells by Zambetti, Noemi A, Raaijmakers, Marc H G P

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Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice by Zambetti, Noemi A., Firestone, Ari J., Remsberg, Jarrett R., Huang, Benjamin J., Wong, Jasmine C., Long, Amanda M., Predovic, Marina, Suciu, Radu M., Inguva, Anagha, Kogan, Scott C., Haigis, Kevin M., Cravatt, Benjamin F., Shannon, Kevin

“…Oncogenic RAS mutations pose substantial challenges for rational drug discovery. Sequence variations within the hypervariable region of Ras isoforms underlie…”
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Polarimetric calibration of SIR-C using point and distributed targets by Sarabandi, K., Pierce, L.E., Dobson, M.C., Ulaby, F.T., Stiles, J.M., Chiu, T.C., De Roo, R., Hartikka, R., Zambetti, A., Freeman, A.

“…In preparation for the Shuttle Imaging Radar-C/XSAR (SIR-C/XSAR) flights, the University of Michigan has been involved in the development of calibration…”
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Abstract A25: In vivo evidence validating the palmitoylation/depalmitoylation cycle as a therapeutic target in NRAS mutant hematologic cancers by Zambetti, Noemi A., Firestone, Ari J., Wong, Jasmine C., Long, Amanda M., Inguva, Anagha, Remsberg, Jarrett R., Suciu, Radu M., Cravatt, Benjamin F., Haigis, Kevin M., Shannon, Kevin

“…Abstract A dynamic cycle of palmitoylation and depalmitoylation stably localizes N-Ras, but not K-Ras-4b, at the plasma membrane. This selective dependency…”
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Genetic Validation of the Palmitoylation/Depalmitoylation Cycle As a Drug Target in NRAS Mutant Hematologic Malignancies In Vivo by Zambetti, Noemi A., Firestone, Ari J., Wong, Jasmine C., Long, Amanda, Inguva, Anagha, Suciu, Radu M., Cravatt, Benjamin F., Haigis, Kevin M., Shannon, Kevin M.

“…The C-terminal hypervariable region (HVR) of Ras proteins specifies post-translational modifications required for their subcellular localization and biologic…”
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Inflammatory Niche Signalling Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Leukemic Evolution in Human Leukemia Predisposition Syndromes by Chen, Si, Zambetti, Noemi A., Ping, Zhen, Kenswil, Keane, Mylona, Maria, Sanders, Mathijs A., Hoogenboezem, Remco, Bindels, Eric, Adisty, Maria, van Strien, Paulina M.H., van der Leije, Cindy, Westers, Theresia M, Cremers, Eline MP, Milanese, Chiara, Mastroberardino, Pier, van Leeuwen, Johannes, Van der Eerden, Bram, Touw, Ivo, Taco, Kuijpers, Kanaar, Roland, van der Loosdrecht, Arjan, Vogl, Thomas, Raaijmakers, Marc H.G.P.

“…Primary alterations of the mesenchymal niche can induce myelodysplasia and acute myeloid leukemia in mouse models, introducing a concept of niche-driven…”
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Deletion of Sbds from Hematopoietic Progenitors Causes Neutropenia in a Mouse Model of Shwachman-Diamond Syndrome By Specifically Blocking Myeloid Lineage Progression at Late Differentiation Stages by Zambetti, Noemi A., Van Strien, Paulina M.H., Valkhof, Marijke G., Adisty, Maria N., Bindels, Eric M.J., Hoogenboezem, Remco M., Sanders, Mathijs A., Rommens, Johanna M., Touw, Ivo P., Raaijmakers, Marc H.G.P.

“…Shwachman-Diamond Syndrome (SDS) is a congenital bone marrow failure disorder characterized by neutropenia and predisposition to leukemia. SDS is associated…”
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Polarimetric calibration of SIR-C using point and distributed targets : SIR-C/X-SAR by KAMAL SARABANDI, PIERCE, L. E, DOBSON, M. C, ULABY, F. T, STILES, J. M, CHIU, T. C, DE ROO, R, HARTIKKA, R, ZAMBETTI, A, FREEMAN, A

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