Search Results - "Zaman, G J"

The Human Multidrug Resistance-Associated Protein MRP is a Plasma Membrane Drug-Efflux Pump by Zaman, G. J. R., Flens, M. J., van Leusden, M. R., de Haas, M., Mulder, H. S., Lankelma, J., Pinedo, H. M., Scheper, R. L., Baas, F., broxterman, H. J., Borst, P.

“…The multidrug-resistance associated protein MRP is a 180- to 195-kDa membrane protein associated with resistance of human tumor cells to cytotoxic drugs. We…”
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Tissue distribution of the multidrug resistance protein by Flens, MJ, Zaman, GJ, van der Valk, P, Izquierdo, MA, Schroeijers, AB, Scheffer, GL, van der Groep, P, de Haas, M, Meijer, CJ, Scheper, RJ

“…The human multidrug resistance protein (MRP) is a 190 kd membrane glycoprotein that can cause resistance of human tumor cells to various anticancer drugs, by…”
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MEK and PI3K-AKT inhibitors synergistically block activated IL7 receptor signaling in T-cell acute lymphoblastic leukemia by Canté-Barrett, K, Spijkers-Hagelstein, J A P, Buijs-Gladdines, J G C A M, Uitdehaag, J C M, Smits, W K, van der Zwet, J, Buijsman, R C, Zaman, G J R, Pieters, R, Meijerink, J P P

“…We identified mutations in the IL7Ra gene or in genes encoding the downstream signaling molecules JAK1, JAK3, STAT5B, N-RAS, K-RAS, NF1, AKT and PTEN in 49% of…”
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Inhibition of the spindle assembly checkpoint kinase TTK enhances the efficacy of docetaxel in a triple-negative breast cancer model by Maia, A.R.R., de Man, J., Boon, U., Janssen, A., Song, J.-Y., Omerzu, M., Sterrenburg, J.G., Prinsen, M.B.W., Willemsen-Seegers, N., de Roos, J.A.D.M., van Doornmalen, A.M., Uitdehaag, J.C.M., Kops, G.J.P.L., Jonkers, J., Buijsman, R.C., Zaman, G.J.R., Medema, R.H.

“…Triple-negative breast cancers (TNBC) are considered the most aggressive type of breast cancer, for which no targeted therapy exists at the moment. These…”
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Expression of the multidrug resistance-associated protein (MRP) gene in human cancers by NOOTER, K, WESTERMAN, A. M, GRATAMA, J. W, KOK, T, EGGERMONT, A. M. M, BOSMAN, F. T, STOTER, G, FLENS, M. J, ZAMAN, G. J. R, SCHEPER, R. J, VAN WINGERDEN, K. E, BURGER, H, OOSTRUM, R, BOERSMA, T, SONNEVELD, P

“…We determined the expression of a newly recognized drug resistance gene, the multidrug resistance-associated protein (MRP) gene, [Cole et al., Science…”
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Identification and profiling of CXCR3–CXCR4 chemokine receptor heteromer complexes by Watts, AO, Lipzig, MMH, Jaeger, WC, Seeber, RM, Zwam, M, Vinet, J, Lee, MMC, Siderius, M, Zaman, GJR, Boddeke, HWGM, Smit, MJ, Pfleger, KDG, Leurs, R, Vischer, HF

“…Background and Purpose The C‐X‐C chemokine receptors 3 (CXCR3) and C‐X‐C chemokine receptors 4 (CXCR4) are involved in various autoimmune diseases and cancers…”
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Congenital Jaundice in Rats with a Mutation in a Multidrug Resistance- Associated Protein Gene by Paulusma, Coen C., Bosma, Piter J., Guido J. R. Zaman, Conny T. M. Bakker, Otter, Marlies, Scheffer, George L., Scheper, Rik J., Borst, Piet, Ronald P. J. Oude Elferink

“…The human Dubin-Johnson syndrome and its animal model, the TR$^-$ rat, are characterized by a chronic conjugated hyperbilirubinemia. TR$^-$ rats are defective…”
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Overexpression of the Gene Encoding the Multidrug Resistance-Associated Protein Results in Increased ATP-Dependent Glutathione S-Conjugate Transport by Muller, Michael, Meijer, Coby, Guido J. R. Zaman, Borst, Piet, Scheper, Rik J., Mulder, Nanno H., Elisabeth G. E. de Vries, Peter L. M. Jansen

“…The multidrug resistance-associated protein (MRP) is a 180- to 195-kDa glycoprotein associated with multidrug resistance of human tumor cells. MRP is mainly…”
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Role of Glutathione in the Export of Compounds from Cells by the Multidrug-Resistance-Associated Protein by Guido J. R. Zaman, Lankelma, Jan, van Tellingen, Olaf, Beijnen, Jos, Dekker, Henk, Paulusma, Coen, Ronald P. J. Oude Elferink, Baas, Frank, Borst, Piet

“…Multidrug-resistance-associated protein (MRP) is a plasma membrane glycoprotein that can confer multidrug resistance (MDR) by lowering intracellular drug…”
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Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells by Evers, R, Zaman, G J, van Deemter, L, Jansen, H, Calafat, J, Oomen, L C, Oude Elferink, R P, Borst, P, Schinkel, A H

“…The human multidrug resistance-associated protein MRP confers resistance to various cytotoxic drugs by lowering the intracellular drug concentration. Recent…”
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Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies by FLENS, M. J, IZQUIERDO, M. A, SCHEFFER, G. I, FRITZ, J. M, MEIJER, C. J. L. M, SCHEPER, R. J, ZAMAN, G. J. R

“…We have generated rat and murine monoclonal antibodies against multidrug resistance-associated protein (MRP), a M(r) 180,000-195,000 membrane glycoprotein…”
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The Human Multidrug Resistance-Associated Protein Functionally Complements the Yeast Cadmium Resistance Factor 1 by Tommasini, Roberto, Evers, Raymond, Vogt, Esther, Mornet, Clotilde, Guido J. R. Zaman, Schinkel, Alfred H., Borst, Piet, Martinoia, Enrico

“…A Saccharomyces cerevisiae strain with a disrupted yeast cadmium resistance factor (YCF1) gene (DTY168) is hypersensitive to cadmium. YCF1 resembles the human…”
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Altered MRP is associated with multidrug resistance and reduced drug accumulation in human SW-1573 cells by EIJDEMS, E. W. H. M, ZAMAN, G. J. R, DE HAAS, M, VERSANTVOORT, C. H. M, FLENS, M. J, SCHEPER, R. J, KAMST, E, BORST, P, BAAS, F

“…We have analysed the contribution of several parameters, e.g. drug accumulation, MDR1 P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP) and…”
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Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines by ZAMAN, G. J. R, VERSANTVOORT, C. H. M, BORST, P, SMIT, J. J. M, EIJDEMS, W. H. M, DE HAAS, M, SMITH, A. J, BROXTERMAN, H. J, MULDER, N. H, DE VRIES, E. G. E, BAAS, F

“…Human cells can become multidrug resistant (MDR) by an increase in the activity of the MDR1 P-glycoprotein or by other, as yet unknown mechanisms, referred to…”
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The elusive factor Xa receptor : failure to detect transcripts that correspond to the published sequence of EPR-1 by ZAMAN, G. J. R, CONWAY, E. M

“…The coagulation protease factor Xa induces cellular responses implicated in cardiovascular and inflammatory disease. Effector-cell protease receptor 1 (EPR-1)…”
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Gene V protein-mediated translational regulation of the synthesis of gene II protein of the filamentous bacteriophage M13: a dispensable function of the filamentous-phage genome by ZAMAN, G. J. R, KAAN, A.M, SCHOENMAKERS, J. G. G, KONINGS, R. N. H

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Classical and novel forms of multidrug resistance and the physiological functions of P-glycoproteins in mammals by Borst, P, Schinkel, A H, Smit, J J, Wagenaar, E, Van Deemter, L, Smith, A J, Eijdems, E W, Baas, F, Zaman, G J

“…In this paper, we review recent work on multidrug resistance (MDR) in Amsterdam. We have generated mice homozygous for a disruption of one of their…”
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Tyrosine kinase activity of purified recombinant cytoplasmic domain of platelet-derived growth factor β-receptor (β-PDGFR) and discovery of a novel inhibitor of receptor tyrosine kinases by Zaman, Guido J.R., Vink, Paul M.F., van den Doelen, Antoon A., Veeneman, Gerrit H., Theunissen, Henri J.M.

“…Aberrant expression of platelet-derived growth factor and its receptor (PDGFR) has been implicated in various human disorders, including cardiovascular disease…”
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Mechanisms of MRP over-expression in four human lung-cancer cell lines and analysis of the MRP amplicon by Eijdems, E W, De Haas, M, Coco-Martin, J M, Ottenheim, C P, Zaman, G J, Dauwerse, H G, Breuning, M H, Twentyman, P R, Borst, P, Baas, F

“…Some multidrug resistant cell lines over-express the gene encoding the multidrug-resistance-associated protein (MRP). In all cell lines reported thus far,…”
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Sequence of a cDNA encoding human ribosomal protein L26 and of a cDNA probably encoding human ribosomal protein L6 by ZAMAN, G. J. R

“…In a search for genes related to non-P-glycoprotein mediated multidrug resistance in human lung cancer cell lines, we isolated three full-length cDNA clones…”
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