Search Results - "Zamai, Loris"

The Yin and Yang of ACE/ACE2 Pathways: The Rationale for the Use of Renin-Angiotensin System Inhibitors in COVID-19 Patients by Zamai, Loris

“…The article describes the rationale for inhibition of the renin-angiotensin system (RAS) pathways as specific targets in patients infected by SARS-CoV-2 in…”
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Upregulation of the Renin-Angiotensin System Pathways and SARS-CoV-2 Infection: The Rationale for the Administration of Zinc-Chelating Agents in COVID-19 Patients by Zamai, Loris

“…The article describes the rationale for the administration of zinc-chelating agents in COVID-19 patients. In a previous work I have highlighted that the…”
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Unveiling Human Non-Random Genome Editing Mechanisms Activated in Response to Chronic Environmental Changes: I. Where Might These Mechanisms Come from and What Might They Have Led To? by Zamai, Loris

“…This article challenges the notion of the randomness of mutations in eukaryotic cells by unveiling stress-induced human non-random genome editing mechanisms…”
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NK Cells and Cancer by Zamai, Loris, Ponti, Cristina, Mirandola, Prisco, Gobbi, Giuliana, Papa, Stefano, Galeotti, Laura, Cocco, Lucio, Vitale, Marco

“…In this review, we overview the main features and functions of NK cells, focusing on their role in cell-mediated immune response to tumor cells. In parallel,…”
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Fluorescent Silica Nanoparticles Targeting Mitochondria: Trafficking in Myeloid Cells and Application as Doxorubicin Delivery System in Breast Cancer Cells by Sola, Federica, Montanari, Mariele, Fiorani, Mara, Barattini, Chiara, Ciacci, Caterina, Burattini, Sabrina, Lopez, Daniele, Ventola, Alfredo, Zamai, Loris, Ortolani, Claudio, Papa, Stefano, Canonico, Barbara

“…Fluorescent silica nanoparticles (SiNPs) appear to be a promising imaging platform, showing a specific subcellular localization. In the present study, we first…”
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Understanding the Synergy of NKp46 and Co-Activating Signals in Various NK Cell Subpopulations: Paving the Way for More Successful NK-Cell-Based Immunotherapy by Zamai, Loris, Del Zotto, Genny, Buccella, Flavia, Gabrielli, Sara, Canonico, Barbara, Artico, Marco, Ortolani, Claudio, Papa, Stefano

“…The NK cell population is characterized by distinct NK cell subsets that respond differently to the various activating stimuli. For this reason, the…”
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The Memories of NK Cells: Innate-Adaptive Immune Intrinsic Crosstalk by Zamai, Loris, Papa, Stefano, Buccella, Flavia, Canonico, Barbara, Luchetti, Francesca, del Zotto, Genny, Ortolani, Claudio, Gabrielli, Sara, Artico, Marco

“…Although NK cells are considered part of the innate immune system, a series of evidences has demonstrated that they possess characteristics typical of the…”
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Lock, Stock and Barrel: Role of Renin-Angiotensin-Aldosterone System in Coronavirus Disease 2019 by Zanza, Christian, Tassi, Michele Fidel, Romenskaya, Tatsiana, Piccolella, Fabio, Abenavoli, Ludovico, Franceschi, Francesco, Piccioni, Andrea, Ojetti, Veronica, Saviano, Angela, Canonico, Barbara, Montanari, Mariele, Zamai, Loris, Artico, Marco, Robba, Chiara, Racca, Fabrizio, Longhitano, Yaroslava

“…Since the end of 2019, the medical-scientific community has been facing a terrible pandemic caused by a new airborne viral agent known as SARS-CoV2. Already in…”
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Long-Term Subjective and Objective Assessment of Smell and Taste in COVID-19 by Ciofalo, Andrea, Cavaliere, Carlo, Masieri, Simonetta, Di Chicco, Alessandra, Fatuzzo, Irene, Lo Re, Federica, Baroncelli, Silvia, Begvarfaj, Elona, Adduci, Andrea, Mezzaroma, Ivano, Mastroianni, Claudio Maria, de Vincentiis, Marco, Greco, Antonio, Zamai, Loris, Artico, Marco

“…Among the first clinical symptoms of the SARS-CoV-2 infection is olfactory−gustatory deficit; this continues for weeks and, in some cases, can be persistent…”
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Hypothesis: Efficacy of early treatments with some NSAIDs in COVID‐19: Might it also depend on their direct and/or indirect zinc chelating ability? by Zamai, Loris

“…The present work argues for the involvement of the zinc chelating ability of some non‐steroidal anti‐inflammatory drugs as an additive mechanism able to…”
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Monocyte Response to Different Campylobacter jejuni Lysates Involves Endoplasmic Reticulum Stress and the Lysosomal⁻Mitochondrial Axis: When Cell Death Is Better Than Cell Survival by Canonico, Barbara, Di Sario, Gianna, Cesarini, Erica, Campana, Raffaella, Luchetti, Francesca, Zamai, Loris, Ortolani, Claudio, Nasoni, Maria Gemma, Baffone, Wally, Papa, Stefano

“…is a Gram-negative spiral-shaped bacterium, commonly associated with gastroenteritis in humans. It explicates its virulence also by the cytolethal distending…”
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Natural killer (NK) cell-mediated cytotoxicity: differential use of TRAIL and Fas ligand by immature and mature primary human NK cells by Zamai, L, Ahmad, M, Bennett, I M, Azzoni, L, Alnemri, E S, Perussia, B

“…Mature natural killer (NK) cells use Ca2+-dependent granule exocytosis and release of cytotoxic proteins, Fas ligand (FasL), and membrane-bound or secreted…”
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Expression of type 1 (interferon gamma) and type 2 (interleukin-13, interleukin-5) cytokines at distinct stages of natural killer cell differentiation from progenitor cells by Loza, Matthew J., Zamai, Loris, Azzoni, Livio, Rosati, Emanuela, Perussia, Bice

“…To determine whether production of type 1 and type 2 cytokines defines discrete stages of natural killer (NK) cell differentiation, cytokine expression was…”
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Tumor necrosis factor–related apoptosis-inducing ligand induces monocytic maturation of leukemic and normal myeloid precursors through a caspase-dependent pathway by Secchiero, Paola, Gonelli, Arianna, Mirandola, Prisco, Melloni, Elisabetta, Zamai, Loris, Celeghini, Claudio, Milani, Daniela, Zauli, Giorgio

“…Treatment of the human HL-60 cell line with tumor necrosis factor (TNF)–related apoptosis-inducing ligand (TRAIL) resulted in rapid (6-24 hours) cytotoxicity…”
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Hypothesis: Possible influence of antivector immunity and SARS‐CoV‐2 variants on efficacy of ChAdOx1 nCoV‐19 vaccine by Zamai, Loris, Rocchi, Marco B. L.

“…The present work provides arguments for the involvement of anti‐vector immunity and of SARS‐CoV‐2 variants on the efficacy of ChAdOx1 nCoV‐19 vaccine. First,…”
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Infection of CD34+ hematopoietic progenitor cells by human herpesvirus 7 (HHV-7) by Mirandola, Prisco, Secchiero, Paola, Pierpaoli, Sabina, Visani, Giuseppe, Zamai, Loris, Vitale, Marco, Capitani, Silvano, Zauli, Giorgio

“…To investigate the tropism of the T-lymphotropic human herpesvirus 7 (HHV-7) for hematopoietic progenitors, cord blood CD34+ cells were inoculated in vitro…”
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Which ones, when and why should renin-angiotensin system inhibitors work against COVID-19? by Montanari, Mariele, Canonico, Barbara, Nordi, Evelyn, Vandini, Daniela, Barocci, Simone, Benedetti, Serena, Carlotti, Eugenio, Zamai, Loris

“…The article describes the possible pathophysiological origin of COVID-19 and the crucial role of renin-angiotensin system (RAS), providing several “converging”…”
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Circulating ACE2 level and zinc/albumin ratio as potential biomarkers for a precision medicine approach to COVID-19 by Benedetti, Serena, Sisti, Davide, Vandini, Daniela, Barocci, Simone, Sudano, Maurizio, Carlotti, Eugenio, Teng, Jade Lee Lee, Zamai, Loris

“…Highly mutable influenza is successfully countered based on individual susceptibility and similar precision-like medicine approach should be effective against…”
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ESCCABase project: A repository in progress by Ortolani, Claudio, D'Atri, Mario, Zamai, Loris, Canonico, Barbara, Del Zotto, Genny, Papa, Stefano

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Murine thymic NK cells are distinct from ILC1s and have unique transcription factor requirements by Gabrielli, Sara, Sun, Mengxi, Bell, April, Zook, Erin C., de Pooter, Renee F., Zamai, Loris, Kee, Barbara L.

“…Group 1 innate lymphoid cells include natural killer (NK) cells and ILC1s, which mediate the response to intracellular pathogens. Thymic NK (tNK) cells were…”
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