Search Results - "Zama, Takeru"

MicroRNA-196a is a putative diagnostic biomarker and therapeutic target for laryngeal cancer by Saito, Koichiro, Inagaki, Koji, Kamimoto, Takahiro, Ito, Yoko, Sugita, Toshiaki, Nakajo, Satoko, Hirasawa, Akira, Iwamaru, Arifumi, Ishikura, Takashi, Hanaoka, Hideki, Okubo, Keisuke, Onozaki, Tokio, Zama, Takeru

“…MicroRNA (miRNA) is an emerging subclass of small non-coding RNAs that regulates gene expression and has a pivotal role for many physiological processes…”
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Polymorphisms in the UGT1A1 gene predict adverse effects of irinotecan in the treatment of gynecologic cancer in Japanese patients by Hirasawa, Akira, Zama, Takeru, Akahane, Tomoko, Nomura, Hiroyuki, Kataoka, Fumio, Saito, Koichiro, Okubo, Keisuke, Tominaga, Eiichiro, Makita, Kazuya, Susumu, Nobuyuki, Kosaki, Kenjiro, Tanigawara, Yusuke, Aoki, Daisuke

“…Irinotecan is a key chemotherapeutic drug used to treat many tumors, including cervical and ovarian cancers; however, irinotecan can cause toxicity,…”
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A fluorescent indicator for visualizing cAMP-induced phosphorylation in vivo by Hagiwara, Masatoshi, Nagai, Yasuo, Miyazaki, Masami, Aoki, Ryoko, Zama, Takeru, Inouye, Satoshi, Hirose, Kenzo, Iino, Masamitsu

“…We have developed a method for visualizing phosphorylation of proteins in living cells using a novel fluorescent indicator composed of two green fluorescent…”
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Erratum: Polymorphisms in the UGT1A1 gene predict adverse effects of irinotecan in the treatment of gynecologic cancer in Japanese patients by Hirasawa, Akira, Zama, Takeru, Akahane, Tomoko, Nomura, Hiroyuki, Kataoka, Fumio, Saito, Koichiro, Okubo, Keisuke, Tominaga, Eiichiro, Makita, Kazuya, Susumu, Nobuyuki, Kosaki, Kenjiro, Tanigawara, Yusuke, Aoki, Daisuke

“…Correction to: Journal of Human Genetics (2013) 58, 794–798; doi:10.1038/jhg.2013.105; published online 3 October 2013 After online publication of this…”
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Scaffold Role of a Mitogen-activated Protein Kinase Phosphatase, SKRP1, for the JNK Signaling Pathway by Zama, Takeru, Aoki, Ryoko, Kamimoto, Takahiro, Inoue, Koichi, Ikeda, Yasuo, Hagiwara, Masatoshi

“…Stress-activated protein kinase (SAPK) pathway-regulating phosphatase 1 (SKRP1) has been identified as a member of the mitogen-activated protein kinase (MAPK)…”
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Cloning of Human PRP4 Reveals Interaction with Clk1 by Kojima, T, Zama, T, Wada, K, Onogi, H, Hagiwara, M

“…Prp4 is a protein kinase of Schizosaccharomyces pombe identified through its role in pre-mRNA splicing, and belongs to a kinase family including mammalian…”
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A Novel Dual Specificity Phosphatase SKRP1 Interacts with the MAPK Kinase MKK7 and Inactivates the JNK MAPK Pathway by Zama, Takeru, Aoki, Ryoko, Kamimoto, Takahiro, Inoue, Koichi, Ikeda, Yasuo, Hagiwara, Masatoshi

“…Mitogen-activated protein kinases (MAPKs) are activated in response to various extracellular stimuli, and their activities are regulated by upstream activating…”
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Coronary artery disease and polymorphisms in a receptor mediating shear stress-dependent platelet activation by MURATA, M, MATSUBARA, Y, KAWANO, K, ZAMA, T, AOKI, N, YOSHINO, H, WATANABE, G, ISHIKAWA, K, IKEDA, Y

“…Platelets play pivotal roles in coronary thrombosis, and antiplatelet therapies are widely used for coronary artery disease (CAD). However, the effects of…”
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Identification of a Novel Kinesin-related Protein, KRMP1, as a Target for Mitotic Peptidyl-prolyl Isomerase Pin1 by Kamimoto, Takahiro, Zama, Takeru, Aoki, Ryoko, Muro, Yoshinao, Hagiwara, Masatoshi

“…Mitosis utilizes a number of kinesin-related proteins (KRPs). Here we report the identification of a novel KRP termed KRMP1, which has a deduced 1780-amino…”
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Genotype frequency of plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism in healthy Japanese males and its relation to PAI-1 levels by Matsubara, Y, Murata, M, Isshiki, I, Watanabe, R, Zama, T, Watanabe, G, Watanabe, K, Ikeda, Y

“…Plasminogen activator inhibitor-1 (PAI-1) plays an inhibitory role in the fibrinolytic enzyme system and is associated with thrombotic diseases. The gene for…”
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Subcutaneous Preadipocytes Are Ideal Candidate To Produce A Large Number Of Functional Platelets In a Culture System by Ono-Uruga, Yukako, Tanaka, Tatsuya, Igari, Atsuko, Moriki, Takanori, Yokoyama, Kenji, Zama, Takeru, Horiuchi, Tadashi, Murata, Mitsuru, Ikeda, Yasuo, Suda, Toshio, Matsubara, Yumiko

“…Platelet transfusions are widely used for patients with severe thrombocytopenia. There are, however, practical problems in the current donor-dependent platelet…”
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Abstract 4089: Regulation of cancer-specific microRNA by aberrant DNA methylation in laryngeal cancer by Yabe, Haruna, Saito, Koichiro, Kamimoto, Takahiro, Kimura, Miwako, Ogawa, Kaoru, Zama, Takeru

“…DNA methylation plays an essential role in the regulation of gene expression during development and differentiation, and furthermore has been reported to be…”
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TNFα‐induced ATF3 expression is bidirectionally regulated by the JNK and ERK pathways in vascular endothelial cells by Inoue, Koichi, Zama, Takeru, Kamimoto, Takahiro, Aoki, Ryoko, Ikeda, Yasuo, Kimura, Hiroshi, Hagiwara, Masatoshi

“…ATF3 (Activating transcription factor 3), a member of the CREB/ATF family, can be induced by stress and growth factors in mammalian cells, and is thought to…”
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A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathway by Zama, Takeru, Aoki, Ryoko, Kamimoto, Takahiro, Inoue, Koichi, Ikeda, Yasuo, Hagiwara, Masatoshi

“…Mitogen-activated protein kinases (MAPKs) are activated in response to various extracellular stimuli, and their activities are regulated by upstream activating…”
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MicroRNA expression signature in laryngeal cancer by Saito, Koichiro, Inagaki, Koji, Naganishi, Hideki, Sugita, Toshiaki, Nakajo, Satoko, Hirasawa, Akira, Zama, Takeru

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Abstract 4039: miR-196a is a novel diagnostic biomarker and therapeutic target for laryngeal cancer by Saito, Koichiro, Inagaki, Koji, Uno, Kosuke, Ito, Yoko, Sugita, Toshiaki, Nakajo, Satoko, Naganishi, Hideki, Yabe, Haruna, Hirasawa, Akira, Okubo, Keisuke, Ogawa, Kaoru, Zama, Takeru

“…Head and neck cancer (HNC) is a major cause of cancer-related mortality and morbidity, comprising roughly 6% of all malignancies worldwide, and laryngeal…”
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Genotype Distribution of Estrogen Receptor Polymorphisms in Men and Postmenopausal Women From Healthy and Coronary Populations and Its Relation to Serum Lipid Levels by Matsubara, Yumiko, Murata, Mitsuru, Kawano, Koichi, Zama, Takeru, Aoki, Nobuo, Yoshino, Hideaki, Watanabe, Gentaro, Ishikawa, Kyozo, Ikeda, Yasuo

“…The cardiovascular protective effects of estrogen are known to be mediated by its beneficial effects on lipid metabolism and its direct actions on the vessel…”
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TNFalpha-induced ATF3 expression is bidirectionally regulated by the JNK and ERK pathways in vascular endothelial cells by Inoue, Koichi, Zama, Takeru, Kamimoto, Takahiro, Aoki, Ryoko, Ikeda, Yasuo, Kimura, Hiroshi, Hagiwara, Masatoshi

“…ATF3 (Activating transcription factor 3), a member of the CREB/ATF family, can be induced by stress and growth factors in mammalian cells, and is thought to…”
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A family with hereditary factor X deficiency with a point mutation Gla 32 to Gln in the Gla domain (factor X Tokyo) by Zama, Takeru, Murata, Mitsuru, Watanabe, Reiko, Yokoyama, Kenji, Moriki, Takanori, Ambo, Hironobu, Murakami, Hiroshi, Kikuchi, Masao, Ikeda, Yasuo

“…We report a new family with hereditary factor X deficiency. The propositus had a markedly prolonged prothrombin time, a mild prolongation of activated partial…”
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A 192 Arg Variant of the Human Paraoxonase (HUMPONA) Gene Polymorphism Is Associated With an Increased Risk for Coronary Artery Disease in the Japanese by Zama, Takeru, Murata, Mitsuru, Matsubara, Yumiko, Kawano, Koichi, Aoki, Nobuo, Yoshino, Hideaki, Watanabe, Gentaro, Ishikawa, Kyozo, Ikeda, Yasuo

“…Abstract Recent reports have suggested that polymorphisms in the human paraoxonase (HUMPONA) gene may be a genetic risk factor for coronary artery disease…”
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