Search Results - "Zalon, Annie J."

Loss of the Spinocerebellar Ataxia type 3 disease protein ATXN3 alters transcription of multiple signal transduction pathways by Zeng, Li, Zhang, Dapeng, McLoughlin, Hayley S, Zalon, Annie J, Aravind, L, Paulson, Henry L

“…Spinocerebellar ataxia type 3 (SCA3) is a dominantly inherited neurodegenerative disorder caused by a polyglutamine-encoding CAG repeat expansion in the ATXN3…”
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Impaired Autophagic-Lysosomal Fusion in Parkinson's Patient Midbrain Neurons Occurs through Loss of ykt6 and Is Rescued by Farnesyltransferase Inhibition by Pitcairn, Caleb, Murata, Naomi, Zalon, Annie J, Stojkovska, Iva, Mazzulli, Joseph R

“…Macroautophagy is a catabolic process that coordinates with lysosomes to degrade aggregation-prone proteins and damaged organelles. Loss of macroautophagy…”
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α-Synuclein: Multiple pathogenic roles in trafficking and proteostasis pathways in Parkinson’s disease by Zalon, Annie J., Quiriconi, Drew J., Pitcairn, Caleb, Mazzulli, Joseph R.

“…Parkinson’s disease (PD) is a common age-related neurodegenerative disorder characterized by the loss of dopaminergic neurons in the midbrain. A hallmark of…”
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Impaired Oligodendrocyte Maturation Is an Early Feature in SCA3 Disease Pathogenesis by Schuster, Kristen H, Zalon, Annie J, Zhang, Hongjiu, DiFranco, Danielle M, Stec, Nicholas R, Haque, Zaid, Blumenstein, Kate G, Pierce, Amanda M, Guan, Yuanfang, Paulson, Henry L, McLoughlin, Hayley S

“…Spinocerebellar ataxia Type 3 (SCA3), the most common dominantly inherited ataxia, is a polyglutamine neurodegenerative disease for which there is no…”
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Antisense Oligonucleotide Silencing Reverses Abnormal Neurochemistry in Spinocerebellar Ataxia 3 Mice by McLoughlin, Hayley S, Gundry, Katherine, Rainwater, Orion, Schuster, Kristen H, Wellik, Isabel G, Zalon, Annie J, Benneyworth, Michael A, Eberly, Lynn E, Öz, Gülin

“…Spinocerebellar ataxia type 3 (SCA3) is the most common dominantly inherited ataxia, and biomarkers are needed to noninvasively monitor disease progression and…”
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ASOs are an effective treatment for disease-associated oligodendrocyte signatures in premanifest and symptomatic SCA3 mice by Schuster, Kristen H, Zalon, Annie J, DiFranco, Danielle M, Putka, Alexandra F, Stec, Nicholas R, Jarrah, Sabrina I, Naeem, Arsal, Haque, Zaid, Zhang, Hanrui, Guan, Yuanfang, McLoughlin, Hayley S

“…Spinocerebellar ataxia type 3 (SCA3) is the most common dominantly inherited ataxia. Currently, no preventive or disease-modifying treatments exist for this…”
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Antisense Oligonucleotide Therapy Targeted Against ATXN3 Improves Potassium Channel–Mediated Purkinje Neuron Dysfunction in Spinocerebellar Ataxia Type 3 by Bushart, David D., Zalon, Annie J., Zhang, Hongjiu, Morrison, Logan M., Guan, Yuanfang, Paulson, Henry L., Shakkottai, Vikram G., McLoughlin, Hayley S.

“…Spinocerebellar ataxia type 3 (SCA3) is the second-most common CAG repeat disease, caused by a glutamine-encoding expansion in the ATXN3 protein. SCA3 is…”
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ASO silencing reverses abnormal neurochemistry in spinocerebellar ataxia 3 mice by McLoughlin, Hayley S., Gundry, Katherine, Rainwater, Orion, Schuster, Kristen H., Wellik, Isabel G., Zalon, Annie J., Benneyworth, Michael A., Eberly, Lynn E., Öz, Gülin

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