Search Results - "Zalloum, Waleed"

Comparative QM/MM Molecular Dynamics and Umbrella Sampling Simulations: Interaction of the Zinc-Bound Intermediate Gem-Diolate Trapoxin A Inhibitor and Acetyl‑l‑lysine Substrate with Histone Deacetylase 8 by Zalloum, Waleed A, Zalloum, Needa

“…Targeting the genetic material without destruction is a priority to develop safe anticancer drugs. Histone deacetylase 8 (HDAC8), which is proved to be…”
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Design, synthesis and structure-activity relationships of 4-phenyl-1H-1,2,3-triazole phenylalanine derivatives as novel HIV-1 capsid inhibitors with promising antiviral activities by Sun, Lin, Huang, Tianguang, Dick, Alexej, Meuser, Megan E., Zalloum, Waleed A., Chen, Chin-Ho, Ding, Xiao, Gao, Ping, Cocklin, Simon, Lee, Kuo-Hsiung, Zhan, Peng, Liu, Xinyong

“…HIV-1 CA is involved in different stages of the viral replication cycle, performing essential roles in both early (uncoating, reverse transcription, nuclear…”
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Discovery of Novel Dihydrothiopyrano[4,3‑d]pyrimidine Derivatives as Potent HIV‑1 NNRTIs with Significantly Reduced hERG Inhibitory Activity and Improved Resistance Profiles by Wang, Zhao, Zalloum, Waleed A, Wang, Wenbo, Jiang, Xiangyi, De Clercq, Erik, Pannecouque, Christophe, Kang, Dongwei, Zhan, Peng, Liu, Xinyong

“…Enlightened by the available structural biology information, a novel series of dihydrothiopyrano­[4,3-d]­pyrimidine derivatives were rationally designed via…”
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Discovery and Mechanistic Investigation of Piperazinone Phenylalanine Derivatives with Terminal Indole or Benzene Ring as Novel HIV-1 Capsid Modulators by Xu, Shujing, Sun, Lin, Zalloum, Waleed A, Huang, Tianguang, Zhang, Xujie, Ding, Dang, Shao, Xiaoyu, Jiang, Xiangyi, Zhao, Fabao, Cocklin, Simon, De Clercq, Erik, Pannecouque, Christophe, Dick, Alexej, Liu, Xinyong, Zhan, Peng

“…HIV-1 capsid (CA) performs multiple roles in the viral life cycle and is a promising target for antiviral development. In this work, we describe the design,…”
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Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV‑1 Capsid Inhibitors with Improved Antiviral Activities by Sun, Lin, Dick, Alexej, Meuser, Megan E, Huang, Tianguang, Zalloum, Waleed A, Chen, Chin-Ho, Cherukupalli, Srinivasulu, Xu, Shujing, Ding, Xiao, Gao, Ping, Kang, Dongwei, De Clercq, Erik, Pannecouque, Christophe, Cocklin, Simon, Lee, Kuo-Hsiung, Liu, Xinyong, Zhan, Peng

“…The HIV-1 CA protein has gained remarkable attention as a promising therapeutic target for the development of new antivirals, due to its pivotal roles in HIV-1…”
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Identification of novel diarylpyrimidine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors against wild-type and K103N mutant viruses by Jiang, Xiangyi, Zalloum, Waleed A., Gao, Zhen, Dai, Jiaojiao, Ji, Xiangkai, Xie, Minghui, Dong, Guanyu, De Clercq, Erik, Huang, Boshi, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong

“…HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) play a crucial role in combination antiretroviral therapy (cART). To further enhance their…”
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Discovery of novel 1,4-disubstituted 1,2,3-triazole phenylalanine derivatives as HIV-1 capsid inhibitors by Jiang, Xiangyi, Wu, Gaochan, Zalloum, Waleed A, Meuser, Megan E, Dick, Alexej, Sun, Lin, Chen, Chin-Ho, Kang, Dongwei, Jing, Lanlan, Jia, Ruifang, Cocklin, Simon, Lee, Kuo-Hsiung, Liu, Xinyong, Zhan, Peng

“…The HIV-1 capsid (CA) protein plays crucial roles in both early and late stages of the viral life cycle, which has intrigued researchers to target it to…”
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Design, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors by Zhang, Xujie, Sun, Lin, Meuser, Megan E., Zalloum, Waleed A., Xu, Shujing, Huang, Tianguang, Cherukupalli, Srinivasulu, Jiang, Xiangyi, Ding, Xiao, Tao, Yucen, Kang, Dongwei, De Clercq, Erik, Pannecouque, Christophe, Dick, Alexej, Cocklin, Simon, Liu, Xinyong, Zhan, Peng

“…HIV-1 capsid (CA) plays indispensable and multiple roles in the life cycle of HIV-1, become an attractive target in antiviral therapy. Herein, we report the…”
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Discovery of novel diarypyrimidine derivatives bearing six-membered non-aromatic heterocycles as potent HIV-1 NNRTIs with improved anti-resistance and drug-like profiles by Jiang, Xiangyi, Huang, Boshi, Zalloum, Waleed A., Chen, Chin-Ho, Ji, Xiangkai, Gao, Zhen, Dai, Jiaojiao, Xie, Minghui, Kang, Dongwei, De Clercq, Erik, Pannecouque, Christophe, Liu, Xinyong, Zhan, Peng

“…Taking our previously reported HIV-1 NNRTIs BH-11c and XJ-10c as lead compounds, series of novel diarypyrimidine derivatives bearing six-membered non-aromatic…”
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Perception, knowledge and attitude towards influenza vaccine during COVID-19 pandemic in Jordanian population by Zalloum, Waleed A., Elayeh, Eman R., Ali, Basel Al Haj, Zalloum, Needa

“…Seasonal influenza is considered as one of the major causes of morbidity and mortality worldwide. This needs solutions to decrease burdens on the healthcare…”
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Discovery and optimizing polycyclic pyridone compounds as anti-HBV agents by Wei, Fenju, Kang, Dongwei, Cherukupalli, Srinivasulu, Zalloum, Waleed A, Zhang, Tao, Liu, Xinyong, Zhan, Peng

“…Hepatitis B disease is caused by the hepatitis B virus (HBV), which is a DNA virus that belongs to the Hepadnaviridae family. It is a considerable health…”
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Exploring the Active Center of the LSD1/CoREST Complex by Molecular Dynamics Simulation Utilizing Its Co-crystallized Co-factor Tetrahydrofolate as a Probe by Zalloum, Waleed A, Zalloum, Hiba M

“…Epigenetic targeting of cancer is a recent effort to manipulate the gene without destroying the genetic material. Lysine-specific demethylase 1 (LSD1) is one…”
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Design, synthesis, and mechanistic investigations of phenylalanine derivatives containing a benzothiazole moiety as HIV-1 capsid inhibitors with improved metabolic stability by Xu, Shujing, Sun, Lin, Dick, Alexej, Zalloum, Waleed A., Huang, Tianguang, Meuser, Megan E., Zhang, Xujie, Tao, Yucen, Cherukupalli, Srinivasulu, Ding, Dang, Ding, Xiao, Gao, Shenghua, Jiang, Xiangyi, Kang, Dongwei, De Clercq, Erik, Pannecouque, Christophe, Cocklin, Simon, Liu, Xinyong, Zhan, Peng

“…Further clinical development of PF74, a lead compound targeting HIV-1 capsid, is impeded by low antiviral activity and inferior metabolic stability. By…”
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The effect of ferrous ions, calcium ions and citric acid on absorption of ciprofloxacin across caco-2 cells: practical and structural approach by El-Sabawi, Dina, Abu-Dahab, Rana, Zalloum, Waleed A, Ijbara, Fadia, Hamdan, Imad I

“…To study the potential influence of selected metal ions on absorption (and hence oral bioavailability of ciprofloxacin (Cipro) in presence and absence of a…”
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The current progress in the use of boron as a platform for novel antiviral drug design by Wang, Shuo, Ren, Yujie, Wang, Zhao, Jiang, Xiangyi, Xu, Shujing, Zhang, Xujie, Zhao, Shujie, Zalloum, Waleed A, Liu, Xinyong, Zhan, Peng

“…Boron has attracted extensive interest due to several FDA-approved boron-containing drugs and other pharmacological agents in clinical trials. As a semimetal,…”
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Design, synthesis, and antiviral evaluation of novel piperidine-substituted arylpyrimidines as HIV-1 NNRTIs by exploring the hydrophobic channel of NNIBP by Zhang, Tao, Zhou, Zhongxia, Zalloum, Waleed A., Wang, Zhao, Fu, Zhipeng, Cherukupalli, Srinivasulu, Feng, Da, Sun, Yanying, Gao, Shenghua, De Clercq, Erik, Pannecouque, Christophe, Kang, Dongwei, Zhan, Peng, Liu, Xinyong

“…[Display omitted] •Novel piperidine-substituted arylpyrimidines were degined.•Compound FT1 displayed the most effective activity.•Pyridine moiety of FT1 was…”
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RNA knockdown by synthetic peptidyl-oligonucleotide ribonucleases: behavior of recognition and cleavage elements under physiological conditions by Gebrezgiabher, Mengisteab, Zalloum, Waleed A., Clarke, David J., Miles, Steven M., Fedorova, Antonina A., Zenkova, Marina A., Bichenkova, Elena V.

“…Sequence-specific protein-based ribonucleases are not found in nature. Absolute sequence selectivity in RNA cleavage in vivo normally requires multi-component…”
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Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors by Jiang, Xiangyi, Huang, Boshi, Rumrill, Shawn, Pople, David, Zalloum, Waleed A., Kang, Dongwei, Zhao, Fabao, Ji, Xiangkai, Gao, Zhen, Hu, Lide, Wang, Zhao, Xie, Minghui, De Clercq, Erik, Ruiz, Francesc X., Arnold, Eddy, Pannecouque, Christophe, Liu, Xinyong, Zhan, Peng

“…HIV-1 reverse transcriptase is one of the most attractive targets for the treatment of AIDS. However, the rapid emergence of drug-resistant strains and…”
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Comparative Molecular Dynamics Simulation of Aggregating and Non‐Aggregating Inhibitor Solutions: Understanding the Molecular Basis of Promiscuity by Ghattas, Mohammad A., Bryce, Richard A., Al Rawashdah, Sara, Atatreh, Noor, Zalloum, Waleed A.

“…The presence of false positives in enzyme inhibition assays is a common problem in early drug discovery, especially for compounds that form colloid aggregates…”
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Novel in vitro and in vivo anti- Helicobacter pylori effects of pomegranate peel ethanol extract by Mayyas, Amal, Abu-Sini, Mohammad, Amr, Rula, Akasheh, Rand T, Zalloum, Waleed, Khdair, Ayman, Hamad, Islam, Aburjai, Talal, Darwish, Rula M, Abu-Qatouseh, Luay

“…Interest in plants with antimicrobial properties has been revived due to emerging problems associated with using antibiotics to eradicate . Accordingly, this…”
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