Search Results - "Zallocchi, Marisa"

Integrin α8 and Pcdh15 act as a complex to regulate cilia biogenesis in sensory cells by Goodman, Linda, Zallocchi, Marisa

“…The way an organism perceives its surroundings depends on sensory systems and the highly specialized cilia present in the neurosensory cells. Here, we describe…”
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Usher protein functions in hair cells and photoreceptors by Cosgrove, Dominic, Zallocchi, Marisa

“…The 10 different genes associated with the deaf/blind disorder, Usher syndrome, encode a number of structurally and functionally distinct proteins, most…”
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EIAV-based retinal gene therapy in the shaker1 mouse model for usher syndrome type 1B: development of UshStat by Zallocchi, Marisa, Binley, Katie, Lad, Yatish, Ellis, Scott, Widdowson, Peter, Iqball, Sharifah, Scripps, Vicky, Kelleher, Michelle, Loader, Julie, Miskin, James, Peng, You-Wei, Wang, Wei-Min, Cheung, Linda, Delimont, Duane, Mitrophanous, Kyriacos A, Cosgrove, Dominic

“…Usher syndrome type 1B is a combined deaf-blindness condition caused by mutations in the MYO7A gene. Loss of functional myosin VIIa in the retinal pigment…”
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Crosslinked-hybrid nanoparticle embedded in thermogel for sustained co-delivery to inner ear by Thakur, Neeraj S, Rus, Iulia, Herbert, Aidan, Zallocchi, Marisa, Chakrabarty, Brototi, Joshi, Aditya D, Lomeo, Joshua, Agrahari, Vibhuti

“…Treatment-induced ototoxicity and accompanying hearing loss are a great concern associated with chemotherapeutic or antibiotic drug regimens. Thus,…”
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Molecular specializations underlying phenotypic differences in inner ear hair cells of zebrafish and mice by Giffen, Kimberlee P, Liu, Huizhan, Yamane, Kacey L, Li, Yi, Chen, Lei, Kramer, Kenneth L, Zallocchi, Marisa, He, David Z

“…Hair cells (HCs) are the sensory receptors of the auditory and vestibular systems in the inner ears of vertebrates that selectively transduce mechanical…”
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Laminin α2-mediated focal adhesion kinase activation triggers Alport glomerular pathogenesis by Delimont, Duane, Dufek, Brianna M, Meehan, Daniel T, Zallocchi, Marisa, Gratton, Michael Anne, Phillips, Grady, Cosgrove, Dominic

“…It has been known for some time that laminins containing α1 and α2 chains, which are normally restricted to the mesangial matrix, accumulate in the glomerular…”
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Endothelin-1 mediated induction of extracellular matrix genes in strial marginal cells underlies strial pathology in Alport mice by Meehan, Daniel T., Delimont, Duane, Dufek, Brianna, Zallocchi, Marisa, Phillips, Grady, Gratton, Michael Anne, Cosgrove, Dominic

“…Alport syndrome, a type IV collagen disorder, manifests as glomerular disease associated with hearing loss with thickening of the glomerular and strial…”
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Role for a novel Usher protein complex in hair cell synaptic maturation by Zallocchi, Marisa, Meehan, Daniel T, Delimont, Duane, Rutledge, Joseph, Gratton, Michael Anne, Flannery, John, Cosgrove, Dominic

“…The molecular mechanisms underlying hair cell synaptic maturation are not well understood. Cadherin-23 (CDH23), protocadherin-15 (PCDH15) and the very large…”
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Characterization of quinoxaline derivatives for protection against iatrogenically induced hearing loss by Zallocchi, Marisa, Hati, Santanu, Xu, Zhenhang, Hausman, William, Liu, Huizhan, He, David Z, Zuo, Jian

“…Hair cell loss is the leading cause of hearing and balance disorders in humans. It can be caused by many factors, including noise, aging, and therapeutic…”
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Biomechanical strain causes maladaptive gene regulation, contributing to Alport glomerular disease by Meehan, Daniel T., Delimont, Duane, Cheung, Linda, Zallocchi, Marisa, Sansom, Steven C., David Holzclaw, J., Rao, Velidi, Cosgrove, Dominic

“…Patients with Alport's syndrome develop a number of pro-inflammatory cytokine and matrix metalloproteinase (MMP) abnormalities that contribute to progressive…”
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Photoreceptors in whirler mice show defective transducin translocation and are susceptible to short-term light/dark changes-induced degeneration by Tian, Mei, Wang, Weimin, Delimont, Duane, Cheung, Linda, Zallocchi, Marisa, Cosgrove, Dominic, Peng, You-Wei

“…Usher syndrome combines congenital hearing loss and retinitis pigmentosa (RP). Mutations in the whirlin gene (DFNB31/WHRN) cause a subtype of Usher syndrome…”
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Light-induced translocation of RGS9-1 and Gβ5L in mouse rod photoreceptors by Tian, Mei, Zallocchi, Marisa, Wang, Weimin, Chen, Ching-Kang, Palczewski, Krzysztof, Delimont, Duane, Cosgrove, Dominic, Peng, You-Wei

“…The transducin GTPase-accelerating protein complex, which determines the photoresponse duration of photoreceptors, is composed of RGS9-1, Gβ5L and R9AP. Here…”
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Clarin-1 acts as a modulator of mechanotransduction activity and presynaptic ribbon assembly by Ogun, Oluwatobi, Zallocchi, Marisa

“…Clarin-1 is a four-transmembrane protein expressed by hair cells and photoreceptors. Mutations in its corresponding gene are associated with Usher syndrome…”
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AZD5438-PROTAC: A selective CDK2 degrader that protects against cisplatin- and noise-induced hearing loss by Hati, Santanu, Zallocchi, Marisa, Hazlitt, Robert, Li, Yuju, Vijayakumar, Sarath, Min, Jaeki, Rankovic, Zoran, Lovas, Sándor, Zuo, Jian

“…Cyclin-dependent kinase 2 (CDK2) is a potential therapeutic target for the treatment of hearing loss and cancer. Previously, we identified AZD5438 and AT7519-7…”
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Clarin-1 acts as a modulator of mechanotransduction activity and presynaptic ribbon assembly by Ogun, Oluwatobi, Zallocchi, Marisa

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Novel biallelic variants in the PLEC gene are associated with severe hearing loss by Zhang, Tianyang, Xu, Zhenhang, Zheng, Danya, Wang, Xuechun, He, Jingchun, Zhang, Luping, Zallocchi, Marisa

“…•Plectin mutations result in non-syndromic hearing loss.•Plectin mutations result in a reduction in the number of pre-synaptic ribbons in hair cells.•Plectin…”
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Piplartine attenuates aminoglycoside-induced TRPV1 activity and protects from hearing loss in mice by Zallocchi, Marisa, Vijayakumar, Sarath, Fleegel, Jonathan, Batalkina, Lyudmila, Brunette, Katyarina E, Shukal, Dhaval, Chen, Zhiyong, Devuyst, Olivier, Liu, Huizhan, He, David Z Z, Imami, Ali Sajid, Hamoud, Abdul-Rizaq Ali, McCullumsmith, Robert, Conda-Sheridan, Martin, De Campos, Luana Janaína, Zuo, Jian

“…Hearing loss is a major health concern in our society, affecting more than 400 million people worldwide. Among the causes, aminoglycoside therapy can result in…”
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MDCK cells express serotonin-regulable 11ß-hydroxysteroid dehydrogenase type 2 by Zallocchi, Marisa L, Damasco, Maria C, Calvo, Juan C, Lantos, Carlos P, Matkovic, Laura B

“…Prior to this work, we found that adrenal as well as extra-adrenal factors activate the response of renal 11ß-hydroxysteroid dehydrogenase 2 to stressful…”
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α1β1 Integrin/Rac1-Dependent Mesangial Invasion of Glomerular Capillaries in Alport Syndrome by Zallocchi, Marisa, Johnson, Brianna M, Meehan, Daniel T, Delimont, Duane, Cosgrove, Dominic

“…Alport syndrome, hereditary glomerulonephritis with hearing loss, results from mutations in type IV collagen COL4A3 , COL4A4 , or COL4A5 genes. The mechanism…”
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Quinoxaline protects zebrafish lateral line hair cells from cisplatin and aminoglycosides damage by Rocha-Sanchez, Sonia M., Fuson, Olivia, Tarang, Shikha, Goodman, Linda, Pyakurel, Umesh, Liu, Huizhan, He, David Z., Zallocchi, Marisa

“…Hair cell (HC) death is the leading cause of hearing and balance disorders in humans. It can be triggered by multiple insults, including noise, aging, and…”
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