Search Results - "Zalkow, L H"

Syntheses and Biological Activities of a Novel Group of Steroidal Derived Inhibitors for Human CDC25A Protein Phosphatase by Peng, Hairuo, Xie, Wenge, Otterness, Diane M, Cogswell, John P, McConnell, Randy T, Carter, H. Luke, Powis, Garth, Abraham, Robert T, Zalkow, Leon H

“…Silica gel supported pyrolysis of an azido-homo-oxa steroid led to rearrangement, presumably by a mechanism similar to that of solution phase Schmidt…”
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Synthesis of congeners and prodrugs. 3. Water-soluble prodrugs of taxol with potent antitumor activity by Deutsch, H. M, Glinski, J. A, Hernandez, M, Haugwitz, R. D, Narayanan, V. L, Suffness, M, Zalkow, Leon H

“…Taxol has shown good in vivo antitumor activity in a number of test systems. The formulation of taxol for antitumor testing has been difficult. Esterification…”
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Novel CDC25A Phosphatase Inhibitors from Pyrolysis of 3-α-Azido-B-homo-6-oxa-4-cholesten-7-one on Silica Gel by Peng, Hairuo, Zalkow, Leon H, Abraham, Robert T, Powis, Garth

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Steroidal derived acids as inhibitors of human Cdc25A protein phosphatase by HAIRUO PENG, WENGE XIE, KIM, D.-I, ZALKOW, L. H, POWIS, G, OTTERNESS, D. M, ABRAHAM, R. T

“…A group of steroidal derived acids were synthesized and found to be human Cdc25A inhibitors. Their potency ranged from 1.1 to > 100 microM; the best ones…”
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A multiwell assay for inhibitors of phosphatidylinositol-3-kinase and the identification of natural product inhibitors by Frew, T, Powis, G, Berggren, M, Abraham, R T, Ashendel, C L, Zalkow, L H, Hudson, C, Qazia, S, Gruszecka-Kowalik, E, Merriman, R

“…A convenient and reliable multisample assay for the screening of inhibitors of the growth factor signalling enzyme phosphatidylinositol-3-kinase (PtdIns-3-K)…”
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Antiviral activity of a derivative of the photosensitive compound Hypericin by Yip, L., Hudson, J.B., Gruszecka-Kowalik, E., Zalkow, L.H., Neil Towers, G.H.

“…Eight synthetic compounds related to the photosensitive antiviral quinonic plant compound hypericin were screened for light-mediated antiviral activity. The…”
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Synthesis of 2-Methyl-(Z)-4-(phenylimino)naphth[2,3-d]oxazol-9-one, a Monoimine Quinone with Selective Cytotoxicity toward Cancer Cells by Benedetti-Doctorovich, Violeta, Burgess, Edward M, Lambropoulos, John, Lednicer, Daniel, Van Derveer, Donald, Zalkow, Leon H

“…A regio and stereospecific synthesis of 2-methyl-(Z)-4-(phenylimino)naphth[2,3-d]oxazol-9-one (1) was achieved by using titanium tetrachloride in methylene…”
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Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G by Zembower, David E, Kam, Chih Min, Powers, James C, Zalkow, Leon H

“…A large series of variously substituted anthraquinones has been synthesized and assayed for inhibitory capacity against human leukocyte elastase (HLE) and…”
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Inhibition of intracellular Ca2+ signalling, cytotoxicity and antitumor activity of the herbicide oryzalin and its analogues by POWIS, G, GALLEGOS, A, ABRAHAM, R. T, ASHENDEL, C. L, ZALKOW, L. H, DORR, R, DVORAKOVA, K, SALMON, S, HARRISON, S, WORZALLA, J

“…Studies were conducted on oryzalin (3,5-dinitro-N,N-di(n-propyl)sulfanilamide), a widely used dinitroaniline sulfonamide herbicide, which was identified from…”
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Inhibition of human immunodeficiency virus replication by the sulfonated stilbene dye resobene by Halliday, Susan M, Lackman-Smith, Carol, Bader, John P, Rice, William G, Clanton, David J, Zalkow, Leon H, Buckheit, Robert W

“…The anti-HIV sulfonated dye, resobene, was found to be a potent inhibitor of the attachment of HIV to target cells, the fusion of envelope- and CD4-expressing…”
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Molecular Similarity from Atomic Electrostatic Multipole Comparisons. Application to Anti-HIV Drugs by Burgess, Edward M, Ruell, J. A, Zalkow, Leon H, Haugwitz, Rudiger D

“…A procedure is presented for the rapid calculation of the similarity between a pair of molecules based on atomic electrostatic multipole comparison. The…”
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Synthesis and pharmacology of irreversible affinity labels as potential cocaine antagonists: aryl 1,4-dialkylpiperazines related to GBR-12783 by Deutsch, H M, Schweri, M M, Culbertson, C T, Zalkow, L H

“…As part of a program aimed at designing irreversible antagonists of the stimulant and reinforcing properties of cocaine, derivatives of GBR-12783 containing…”
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A multisample assay for inhibitors of phosphatidylinositol phospholipase C: identification of naturally occurring peptide inhibitors with antiproliferative activity by Hill, S R, Bonjouklian, R, Powis, G, Abraham, R T, Ashendel, C L, Zalkow, L H

“…A convenient and reliable multisample assay for the screening of inhibitors of the growth factor signalling enzyme phosphatidylinositol specific phospholipase…”
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Quinobene, a new potent anti-HIV agent by Gruszecka-Kowalik, E, Haugwitz, R D, Zalkow, L H

“…A simple synthesis of the sulfonated azo dye Quinobene (3) and its derivatives, as well as the results of their evaluation in anti-HIV screening have been…”
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Novel quinone antiproliferative inhibitors of phosphatidylinositol-3-kinase by Frew, T, Powis, G, Berggren, M, Gallegos, A, Abraham, R T, Ashendel, C L, Zalkow, L H, Hudson, C, Gruszecka-Kowalik, E, Burgess, E M

“…The inhibition of phosphatidylinositol-3-kinase (PtdIns-3-kinase), protein kinase C and c-Src protein tyrosine kinase by a series of halogenated…”
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Increased intracellular Ca2+ signaling caused by the antitumor agent helenalin and its analogues by POWIS, G, GALLEGOS, A, ABRAHAM, R. T, ASHENDEL, C. L, ZALKOW, L. H, GRINDEY, G. B, BONJOUKLIAN, R

“…The antitumor sesquiterpene lactone helenalin, which is found in species of the plant genus Helenium, caused a marked potentiation of the increases in…”
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Induction by carrot allelochemicals of insecticide-metabolising enzymes in the southern armyworm (Spodoptera eridania) by Brattsten, L B, Evans, C K, Bonetti, S, Zalkow, L H

“…Carrot foliage monoterpenes induce cytochrome P-450 up to 2.9-fold, NADPH cytochrome c (P-450) reductase up to 1.6-fold, NADPH-oxidation up to 3.8-fold, aldrin…”
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Capillary supercritical fluid chromatography of pyrrolizidine alkaloids by Holzer, G, Zalkow, L H, Asibal, C F

“…The application of capillary supercritical fluid chromatography (SFC) for the separation of pyrrolizidine alkaloids (PAs) is examined. Most of these compounds…”
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Pyrrolizidine Alkaloids from Heliotropium rotundifolium by Asibal, Clarita F, Gelbaum, Leslie T, Zalkow, Leon H

“…Heliotropium rotundifolium was shown to contain, in addition to the previously isolated europine [1], three other alkaloids: heliotrine [2], lasiocarpine [3],…”
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Pyrrolizidine Alkaloids from Cynoglossum creticum. Synthesis of the Pyrrolizidine Alkaloids Echinatine, Rinderine, and Analogues by Asibal, Clarita F, Glinski, Jan A, Gelbaum, Leslie T, Zalkow, Leon H

“…Reinvestigation of Cynoglossum creticum led to the isolation of the previously reported echinatine [1] and heliosupine [2] as well as rinderine [3],…”
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