Search Results - "Zalko, D."

Genotoxicity of 11 heavy metals detected as food contaminants in two human cell lines by Kopp, B., Zalko, D., Audebert, M., Dertinger, S.

“…Heavy metals, such as arsenic (As), antimony (Sb), barium (Ba), cadmium (Cd), cobalt (Co), germanium (Ge), lead (Pb), nickel (Ni), tellurium (Te), and vanadium…”
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Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis by Desdoits-Lethimonier, C., Lesné, L., Gaudriault, P., Zalko, D., Antignac, J.P., Deceuninck, Y., Platel, C., Dejucq-Rainsford, N., Mazaud-Guittot, S., Jégou, B.

“…Abstract STUDY QUESTION Are bisphenol A (BPA) and BPA analogs (BPA-A) safe for male human reproductive function? SUMMARY ANSWER The endocrine function of human…”
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Use of the γH2AX assay for assessing the genotoxicity of bisphenol A and bisphenol F in human cell lines by Audebert, Marc, Dolo, L., Perdu, E., Cravedi, J. -P., Zalko, D.

“…Bisphenol A (BPA) and bisphenol F (BPF) are widely used to manufacture plastics and epoxy resins. Both compounds have been shown to be present in the…”
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Human testis steroidogenesis is inhibited by phthalates by Desdoits-Lethimonier, C., Albert, O., Le Bizec, B., Perdu, E., Zalko, D., Courant, F., Lesné, L., Guillé, F., Dejucq-Rainsford, N., Jégou, B.

“…BACKGROUND Phthalic acid esters are widely used in the manufacture of plastics. Numerous studies have shown that these phthalates impair testicular…”
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Disposition of fipronil in rats by Cravedi, J.P., Delous, G., Zalko, D., Viguié, C., Debrauwer, L.

“…•We analyzed the tissue distribution and the biotransformation of fipronil in rats.•After a single oral dose, the highest residue levels were found in adipose…”
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Genotoxicity and mutagenicity assessment of food contaminant mixtures present in the French diet by Kopp, B., Vignard, J., Mirey, G., Fessard, V., Zalko, D., Le Hgarat, L., Audebert, M.

“…Through diet, people are exposed simultaneously to a variety of contaminants (e.g. heavy metals, mycotoxins, pesticides) that could have combined adverse…”
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Comparison of the metabolism of 10 chemicals in human and pig skin explants by Géniès, C., Jamin, E. L., Debrauwer, L., Zalko, D., Person, E. N., Eilstein, J., Grégoire, S., Schepky, A., Lange, D., Ellison, C., Roe, A., Salhi, S., Cubberley, R., Hewitt, N. J., Rothe, H., Klaric, M., Duplan, H., Jacques‐Jamin, C.

“…Skin metabolism is important to consider when assessing local toxicity and/or penetration of chemicals and their metabolites. If human skin supply is limited,…”
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Use of the γH2AX assay for assessing the genotoxicity of polycyclic aromatic hydrocarbons in human cell lines by Audebert, M., Riu, A., Jacques, C., Hillenweck, A., Jamin, E.L., Zalko, D., Cravedi, J.-P.

“…The development of in vitro genotoxic assays as an alternative method to animal experimentation is of growing interest in the context of the implementation of…”
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Effect of skin metabolism on dermal delivery of testosterone: qualitative assessment using a new short-term skin model by Jacques, C, Perdu, E, Jamin, E L, Cravedi, J P, Mavon, A, Duplan, H, Zalko, D

“…The skin is a metabolically active organ expressing biotransformation enzymes able to metabolize both endogenous molecules and xenobiotics. We investigated the…”
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Steroid receptor profiling of vinclozolin and its primary metabolites by Molina-Molina, José-Manuel, Hillenweck, Anne, Jouanin, Isabelle, Zalko, Daniel, Cravedi, Jean-Pierre, Fernández, Mariana-Fátima, Pillon, Arnaud, Nicolas, Jean-Claude, Olea, Nicolás, Balaguer, Patrick

“…Several pesticides and fungicides commonly used to control agricultural and indoor pests are highly suspected to display endocrine-disrupting effects in…”
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Biotransformation of genistein and bisphenol A in cell lines used for screening endocrine disruptors by Bursztyka, J., Perdu, E., Pettersson, K., Pongratz, I., Fernández-Cabrera, M., Olea, N., Debrauwer, L., Zalko, D., Cravedi, J.P.

“…In vitro assays provide the opportunity for generating alerts for chemicals which interact with hormone receptors and are also valuable tools for mechanistic…”
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Characterisation of bioactive compounds in infant formulas using immobilised recombinant estrogen receptor-α affinity columns by Riu, A., Balaguer, P., Perdu, E., Pandelova, M., Piccinelli, R., Gustafsson, J.-A., Leclercq, C., Schramm, K.-W., Dagnino, S., Debrauwer, L., Cravedi, J.-P., Zalko, D.

“…In this study, the use of recombinant estrogen receptor alpha (ERα)-based affinity columns was reported, for the isolation and the identification of estrogenic…”
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Modulation of hepatic xenobiotic metabolizing enzymes following chronic low-dose exposure to PFOA in mice by Person, E., Sola-Tapias, N., Bruel, S., Robert, H., Mercier-Bonin, M., Zalko, D., Cabaton, N.J.

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Biotransformation of bisphenol A and genistein in MCF7, HC11 and HepG2 cell lines used for testing endocrine disruptors by Bursztyka, J., Perdu, E., Pettersson, K., Pongratz, I., Fernández-Cabrera, M., Olea, N., Gamet-Payrastre, L., Cravedi, J.P., Zalko, D.

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Halogenated Bisphenol-A Analogs Act as Obesogens in Zebrafish Larvae (Danio rerio) by Riu, Anne, McCollum, Catherine W., Pinto, Caroline L., Grimaldi, Marina, Hillenweck, Anne, Perdu, Elisabeth, Zalko, Daniel, Bernard, Laure, Laudet, Vincent, Balaguer, Patrick, Bondesson, Maria, Gustafsson, Jan-Ake

“…Obesity has increased dramatically over the past decades, reaching epidemic proportions. The reasons are likely multifactorial. One of the suggested causes is…”
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Exposure assessment of French women and their newborns to tetrabromobisphenol-A: Occurrence measurements in maternal adipose tissue, serum, breast milk and cord serum by Cariou, Ronan, Antignac, Jean-Philippe, Zalko, Daniel, Berrebi, Alain, Cravedi, Jean-Pierre, Maume, Daniel, Marchand, Philippe, Monteau, Fabrice, Riu, Anne, Andre, François, bizec, Bruno Le

“…A French monitoring study was initiated to evaluate the exposure of fetus and newborn to brominated flame retardants (BFR). A previously developed…”
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The GOLIATH Project: Towards an Internationally Harmonised Approach for Testing Metabolism Disrupting Compounds by Legler, Juliette, Zalko, Daniel, Jourdan, Fabien, Jacobs, Miriam, Fromenty, Bernard, Balaguer, Patrick, Bourguet, William, Munic Kos, Vesna, Nadal, Angel, Beausoleil, Claire, Cristobal, Susana, Remy, Sylvie, Ermler, Sibylle, Margiotta-Casaluci, Luigi, Griffin, Julian L, Blumberg, Bruce, Chesné, Christophe, Hoffmann, Sebastian, Andersson, Patrik L, Kamstra, Jorke H

“…The purpose of this project report is to introduce the European "GOLIATH" project, a new research project which addresses one of the most urgent regulatory…”
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Weight of evidence evaluation of the metabolism disrupting effects of triphenyl phosphate using an expert knowledge elicitation approach by Beausoleil, Claire, Thébault, Anne, Andersson, Patrik, Cabaton, Nicolas J., Ermler, Sibylle, Fromenty, Bernard, Garoche, Clémentine, Griffin, Julian L., Hoffmann, Sebastian, Kamstra, Jorke H., Kubickova, Barbara, Lenters, Virissa, Kos, Vesna Munic, Poupin, Nathalie, Remy, Sylvie, Sapounidou, Maria, Zalko, Daniel, Legler, Juliette, Jacobs, Miriam N., Rousselle, Christophe

“…Identification of Endocrine-Disrupting Chemicals (EDCs) in a regulatory context requires a high level of evidence. However, lines of evidence (e.g. human, in…”
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138 Characterization of xenobiotic metabolizing enzymes of a reconstructed human epidermal model from adult hair follicles by Bacqueville, D., Jacques-Jamin, C., Duprat, l, Jamin, E., Guiraud, B., Bessou-Touya, S., Zalko, D., Duplan, H.

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Electrospray Ionization Mass Spectrometric Study of N-Oxidation Products of Clenbuterol by Debrauwer, L., Zalko, D., Bories, G., Tulliez, J.

“…Electrospray ionization has been used for the mass spectrometric study of N‐oxidation products of clenbuterol, i.e. its hydroxylamine, nitro and nitroso…”
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