Search Results - "Zalkin, Howard"

Coupled Formation of an Amidotransferase Interdomain Ammonia Channel and a Phosphoribosyltransferase Active Site by Krahn, Joseph M, Kim, Jeong Hyun, Burns, Mark R, Parry, Ronald J, Zalkin, Howard, Smith, Janet L

“…Activation of glutamine phosphoribosylpyrophosphate (PRPP) amidotransferase (GPATase) by binding of a PRPP substrate analog results in the formation of a 20 Å…”
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Functional Dissection of the Bacillus subtilis pur Operator Site by Bera, Aloke Kumar, Zhu, Jianghai, Zalkin, Howard, Smith, Janet L

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Crystal Structure of Bacillus subtilis YabJ, a Purine Regulatory Protein and Member of the Highly Conserved YjgF Family by Sinha, Sangita, Rappu, Pekka, Lange, S. C., Mäntsälä, Pekka, Zalkin, Howard, Smith, Janet L.

“…The yabJ gene in Bacillus subtillis is required for adenine-mediated repression of purine biosynthetic genes in vivo and codes for an acid-soluble, 14-kDa…”
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Structure of the Allosteric Regulatory Enzyme of Purine Biosynthesis by Smith, Janet L., Zaluzec, Eugene J., Wery, Jean-Pierre, Niu, Liwen, Switzer, Robert L., Zalkin, Howard, Satow, Yoshinori

“…Multiwavelength anomalous diffraction (MAD) has been used to determine the structure of the regulatory enzyme of de novo synthesis of purine nucleotides,…”
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The Purine Repressor of Bacillus subtilis: a Novel Combination of Domains Adapted for Transcription Regulation by Sinha, Sangita C, Krahn, Joseph, Shin, Byung Sik, Tomchick, Diana R, Zalkin, Howard, Smith, Janet L

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A Role for a Highly Conserved Protein of Unknown Function in Regulation of Bacillus subtilis purA by the Purine Repressor by Rappu, P, Shin, B S, Zalkin, H, Mäntsälä, P

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Structure and Function of the Glutamine Phosphoribosylpyrophosphate Amidotransferase Glutamine Site and Communication with the Phosphoribosylpyrophosphate Site by Kim, J H, Krahn, J M, Tomchick, D R, Smith, J L, Zalkin, H

“…Glutamine phosphoribosylpyrophosphate (PRPP) amidotransferase from Escherichia coli exhibits a basal PRPP-independent glutaminase activity having a k cat / K m…”
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Crystal structure of glutamine phosphoribosylpyrophosphate amidotransferase from Escherichia coli by Muchmore, CHRISTINE R. A., Krahn, Joseph M., Smith, Janet L., Kim, Jeong Hyun, Zalkin, Howard

“…Crystal structures of glutamine phosphoribosylpyrophosphate (PRPP) amidotransferase from Escherichia coli have been determined to 2.0‐Å resolution in the…”
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The X-ray Structure of the PurR-Guanine-purF Operator Complex Reveals the Contributions of Complementary Electrostatic Surfaces and a Water-mediated Hydrogen Bond to Corepressor Specificity and Binding Affinity by Schumacher, Maria A., Glasfeld, Arthur, Zalkin, Howard, Brennan, Richard G.

“…The purine repressor, PurR, is the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli. This dimeric transcription factor…”
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Dual Role for the Glutamine Phosphoribosylpyrophosphate Amidotransferase Ammonia Channel by Bera, Aloke Kumar, Smith, Janet L., Zalkin, Howard

“…Glutamine phosphoribosylpyrophosphate (PRPP) amidotransferase catalyzes the first reaction of de novopurine nucleotide synthesis in two steps at two sites…”
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Analysis of the Chicken GPAT/AIRC Bidirectional Promoter for de Novo Purine Nucleotide Synthesis (∗) by Gavalas, Anthony, Zalkin, Howard

“…GPAT and AIRC encode two enzymes that catalyze steps 1 and 6 plus 7, respectively, of the de novo purine biosynthetic pathway. The chicken genes are closely…”
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Interdomain Signaling in Glutamine Phosphoribosylpyrophosphate Amidotransferase by Bera, A K, Chen, S, Smith, J L, Zalkin, H

“…The glutamine phosphoribosylpyrophosphate (PRPP) amidotransferase-catalyzed synthesis of phosphoribosylamine from PRPP and glutamine is the sum of two…”
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Mechanism of the Synergistic End-Product Regulation of Bacillus subtilis Glutamine Phosphoribosylpyrophosphate Amidotransferase by Nucleotides by Chen, Sihong, Tomchick, Diana R, Wolle, Dana, Hu, Ping, Smith, Janet L, Switzer, Robert L, Zalkin, Howard

“…De novo purine nucleotide synthesis is regulated, at least in part, by end-product inhibition of glutamine PRPP amidotransferase. An important feature of this…”
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Temperature-Dependent Function of the Glutamine Phosphoribosylpyrophosphate Amidotransferase Ammonia Channel and Coupling with Glycinamide Ribonucleotide Synthetase in a Hyperthermophile by Bera, A K, Chen, S, Smith, J L, Zalkin, H

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Binding of cytosolic aconitase to the iron responsive element of porcine mitochondrial aconitase mRNA by Zheng, L, Kennedy, M C, Blondin, G A, Beinert, H, Zalkin, H

“…The 5' end of porcine mitochondrial aconitase mRNA contains an iron responsive element (IRE)-like secondary structure (T. Dandekar, R. Stripecke, N. K. Gray,…”
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Mutations in PurBox1 of the Bacillus subtilis pur operon control site affect adenine-regulated expression in vivo by Xuan, Jinsong, Zalkin, Howard, Weng, Manli

“…Transcription of the Bacillus subtilis pur operon is regulated by a purine repressor (PurR)-DNA control site interaction. The pur operon control site has two…”
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A Stable Carbocyclic Analog of 5-Phosphoribosyl-1-pyrophosphate to Probe the Mechanism of Catalysis and Regulation of Glutamine Phosphoribosylpyrophosphate Amidotransferase by Kim, Jeong Hyun, Wolle, Dana, Haridas, Kochat, Parry, Ronald J., Smith, Janet L., Zalkin, Howard

“…Glutamine phosphoribosylpyrophosphate (PRPP) amidotransferase catalysis and regulation were studied using a new stable carbocyclic analog of PRPP,…”
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Crystal structure of lacI member, PurR, bound to DNA : minor groove binding by α helices by SCHUMACHER, M. A, CHOI, K. Y, ZALKIN, H, BRENNAN, R. G

“…The three-dimensional structure of a ternary complex of the purine repressor, PurR, bound to both its corepressor, hypoxanthine, and the 16-base pair purF…”
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Enzymes utilizing glutamine as an amide donor by Zalkin, H, Smith, J L

“…Amide nitrogen from glutamine is a major source of nitrogen atoms incorporated biosynthetically into other amino acids, purine and pyrimidine bases,…”
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Utilization of ammonia for tryptophan synthesis by Zalkin, H, Murphy, T

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