Search Results - "Zalk, Ran"

Intracellular calcium leak in heart failure and atrial fibrillation: a unifying mechanism and therapeutic target by Dridi, Haikel, Kushnir, Alexander, Zalk, Ran, Yuan, Qi, Melville, Zephan, Marks, Andrew R.

“…Ca 2+ is a fundamental second messenger in all cell types and is required for numerous essential cellular functions, including cardiac and skeletal muscle…”
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Structural Basis for Gating and Activation of RyR1 by des Georges, Amédée, Clarke, Oliver B., Zalk, Ran, Yuan, Qi, Condon, Kendall J., Grassucci, Robert A., Hendrickson, Wayne A., Marks, Andrew R., Frank, Joachim

“…The type-1 ryanodine receptor (RyR1) is an intracellular calcium (Ca2+) release channel required for skeletal muscle contraction. Here, we present cryo-EM…”
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Structure of a mammalian ryanodine receptor by Zalk, Ran, Clarke, Oliver B., des Georges, Amédée, Grassucci, Robert A., Reiken, Steven, Mancia, Filippo, Hendrickson, Wayne A., Frank, Joachim, Marks, Andrew R.

“…Ryanodine receptors (RyRs) mediate the rapid release of calcium (Ca 2+ ) from intracellular stores into the cytosol, which is essential for numerous cellular…”
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Structural basis for SARM1 inhibition and activation under energetic stress by Sporny, Michael, Guez-Haddad, Julia, Khazma, Tami, Yaron, Avraham, Dessau, Moshe, Shkolnisky, Yoel, Mim, Carsten, Isupov, Michail N, Zalk, Ran, Hons, Michael, Opatowsky, Yarden

“…SARM1, an executor of axonal degeneration, displays NADase activity that depletes the key cellular metabolite, NAD+, in response to nerve injury. The basis of…”
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Perturbed N-glycosylation of Halobacterium salinarum archaellum filaments leads to filament bundling and compromised cell motility by Sofer, Shahar, Vershinin, Zlata, Mashni, Leen, Zalk, Ran, Shahar, Anat, Eichler, Jerry, Grossman-Haham, Iris

“…The swimming device of archaea—the archaellum—presents asparagine (N)-linked glycans. While N-glycosylation serves numerous roles in archaea, including…”
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Ryanodine Receptor Oxidation Causes Intracellular Calcium Leak and Muscle Weakness in Aging by Andersson, Daniel C., Betzenhauser, Matthew J., Reiken, Steven, Meli, Albano C., Umanskaya, Alisa, Xie, Wenjun, Shiomi, Takayuki, Zalk, Ran, Lacampagne, Alain, Marks, Andrew R.

“…Age-related loss of muscle mass and force (sarcopenia) contributes to disability and increased mortality. Ryanodine receptor 1 (RyR1) is the skeletal muscle…”
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Modulation of the ryanodine receptor and intracellular calcium by Zalk, Ran, Lehnart, Stephan E, Marks, Andrew R

“…Ryanodine receptors (RyRs)/Ca2+ release channels, on the endoplasmic and sarcoplasmic reticulum of most cell types, are required for intracellular Ca2+ release…”
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Hyperuricemia and gout caused by missense mutation in d-lactate dehydrogenase by Drabkin, Max, Yogev, Yuval, Zeller, Lior, Zarivach, Raz, Zalk, Ran, Halperin, Daniel, Wormser, Ohad, Gurevich, Evgenia, Landau, Daniel, Kadir, Rotem, Perez, Yonatan, Birk, Ohad S

“…Gout is caused by deposition of monosodium urate crystals in joints when plasma uric acid levels are chronically elevated beyond the saturation threshold,…”
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Targeting the Mitochondrial Protein VDAC1 as a Potential Therapeutic Strategy in ALS by Shteinfer-Kuzmine, Anna, Argueti-Ostrovsky, Shirel, Leyton-Jaimes, Marcel F., Anand, Uttpal, Abu-Hamad, Salah, Zalk, Ran, Shoshan-Barmatz, Varda, Israelson, Adrian

“…Impaired mitochondrial function has been proposed as a causative factor in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), caused by…”
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Structural basis for the intracellular regulation of ferritin degradation by Hoelzgen, Fabian, Nguyen, Thuy T. P., Klukin, Elina, Boumaiza, Mohamed, Srivastava, Ayush K., Kim, Elizabeth Y., Zalk, Ran, Shahar, Anat, Cohen-Schwartz, Sagit, Meyron-Holtz, Esther G., Bou-Abdallah, Fadi, Mancias, Joseph D., Frank, Gabriel A.

“…The interaction between nuclear receptor coactivator 4 (NCOA4) and the iron storage protein ferritin is a crucial component of cellular iron homeostasis. The…”
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SMAC/Diablo controls proliferation of cancer cells by regulating phosphatidylethanolamine synthesis by Pandey, Swaroop Kumar, Paul, Avijit, Shteinfer‐Kuzmine, Anna, Zalk, Ran, Bunz, Uwe, Shoshan‐Barmatz, Varda

“…SMAC/Diablo, a pro‐apoptotic protein, yet it is overexpressed in several cancer types. We have described a noncanonical function for SMAC/Diablo as a regulator…”
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Reply to ‘Mechanisms of ryanodine receptor 2 dysfunction in heart failure’ by Dridi, Haikel, Kushnir, Alexander, Zalk, Ran, Yuan, Qi, Melville, Zephan, Marks, Andrew R.

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Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans by Khazma, Tami, Grossman, Atira, Guez-Haddad, Julia, Feng, Chengye, Dabas, Hadas, Sain, Radhika, Weitman, Michal, Zalk, Ran, Isupov, Michail N., Hammarlund, Marc, Hons, Michael, Opatowsky, Yarden

“…Wallerian axonal degeneration (WD) does not occur in the nematode C. elegans, in contrast to other model animals. However, WD depends on the NADase activity of…”
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Single-channel recordings of RyR1 at microsecond resolution in CMOS-suspended membranes by Hartel, Andreas J. W., Ong, Peijie, Schroeder, Indra, Giese, M. Hunter, Shekar, Siddharth, Clarke, Oliver B., Zalk, Ran, Marks, Andrew R., Hendrickson, Wayne A., Shepard, Kenneth L.

“…Single-channel recordings are widely used to explore functional properties of ion channels. Typically, such recordings are performed at bandwidths of less than…”
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RyR1-related myopathy mutations in ATP and calcium binding sites impair channel regulation by Yuan, Qi, Dridi, Haikel, Clarke, Oliver B, Reiken, Steven, Melville, Zephan, Wronska, Anetta, Kushnir, Alexander, Zalk, Ran, Sittenfeld, Leah, Marks, Andrew R

“…The type 1 ryanodine receptor (RyR1) is an intracellular calcium (Ca ) release channel on the sarcoplasmic/endoplasmic reticulum that is required for skeletal…”
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Intensity matters: Ryanodine receptor regulation during exercise by Kohl, Tobias, Weninger, Gunnar, Zalk, Ran, Eaton, Philip, Lehnart, Stephan E.

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Oligomeric states of the voltage-dependent anion channel and cytochrome c release from mitochondria by Zalk, Ran, Israelson, Adrian, Garty, Erez S, Azoulay-Zohar, Heftsi, Shoshan-Barmatz, Varda

“…The VDAC (voltage-dependent anion channel) plays a central role in apoptosis, participating in the release of apoptogenic factors including cytochrome c. The…”
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Characterization of DIDS-sensitive ATP accumulation in brain synaptic vesicles by Zalk, Ran, Shoshan-Barmatz, Varda

“…ATP is an excitatory neurotransmitter in the central and peripheral nervous system. We investigated ATP accumulation in highly purified brain synaptic vesicles…”
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ATP-binding sites in brain p97/VCP (valosin-containing protein), a multifunctional AAA ATPase by Zalk, Ran, Shoshan-Barmatz, Varda

“…VCP (valosin-containing protein) or p97 is a member of the AAA family (ATPases associated with a variety of cellular activities family), a diverse group of…”
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Ca2+ Release Channels Join the ‘Resolution Revolution’ by Zalk, Ran, Marks, Andrew R.

“…Ryanodine receptors (RyRs) are calcium release channels expressed in the sarcoendoplasmic reticula of many cell types including cardiac and skeletal muscle…”
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