Search Results - "Zaleski, Jeffrey M."

Metal complex–DNA interactions: from transcription inhibition to photoactivated cleavage by Boerner, Leigh JK, Zaleski, Jeffrey M

“…Metal ions and complexes, because of their cationic character, three-dimensional structural profiles, and propensity for performing hydrolysis, redox, or…”
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Characterization and initial demonstration of in vivo efficacy of a novel heat-activated metalloenediyne anti-cancer agent by Garrett, Joy, Metzger, Erin, Dewhirst, Mark W., Pollok, Karen E., Turchi, John J., Le Poole, Isabelle C., Couch, Kira, Lew, Logan, Sinn, Anthony, Zaleski, Jeffrey M., Dynlacht, Joseph R.

“…Enediynes are anti-cancer agents that are highly cytotoxic due to their propensity for low thermal activation of radical generation. The diradical intermediate…”
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Expansion by Contraction: Diversifying the Photochemical Reactivity Scope of Diazo-oxochlorins toward Development of in Situ Alkylating Agents by Köpke, Tillmann, Pink, Maren, Zaleski, Jeffrey M

“…Irradiation of 2-diazo-3-oxochlorins (200 W, λ ≥ 345 nm, 10 °C) in the presence of nucleophilic and biomimetic substrates 1-butanol, tosylhydrazine, or…”
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Elucidation of the extraordinary 4-membered pyrrole ring-contracted azeteoporphyrinoid as an intermediate in chlorin oxidation by Köpke, Tillmann, Pink, Maren, Zaleski, Jeffrey M

“…Reaction of 2,3-dioxochlorins with benzeneselenic anhydride (BSA) results in the formation of unusual ring-contracted azetine derivatives that further react…”
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Ambient Temperature Activation of Haloporphyrinic-Enediynes:  Electronic Contributions to Bergman Cycloaromatization by Nath, Mahendra, Huffman, John C, Zaleski, Jeffrey M

“…We have synthesized the nickel(II) 2,3-bis(haloethynyl)-5,10,15,20-tetraphenylporphyrins with −Br (2a) or −I (2b) at the alkyne termini position from the…”
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Surface-Ligand-Controlled Enhancement of Carrier Density in Plasmonic Tungsten Oxide Nanocrystals: Spectroscopic Observation of Trap-State Passivation via Multidentate Metal Phosphonate Bonding by Lee, Jacob T, Hati, Sumon, Fahey, Mackenzie M, Zaleski, Jeffrey M, Sardar, Rajesh

“…The localized surface plasmon resonance (LSPR) properties of nanocrystals (NCs) allow manipulation of optical responses by controlling their morphology, free…”
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Electronic Structure of Activated Bleomycin:  Oxygen Intermediates in Heme versus Non-Heme Iron by Neese, Frank, Zaleski, Jeffrey M, Loeb Zaleski, Kelly, Solomon, Edward I

“…Bleomycin (BLM) is a glycopeptide antibiotic produced by the fungus Streptomyces verticillus which is used clinically for anticancer therapy. It is most active…”
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Potentiation of metalloenediyne cytotoxicity by hyperthermia by Routt, Stefan M, Zhu, Ju, Zaleski, Jeffrey M, Dynlacht, Joseph R

“…Enediynes are potent inducers of DNA damage, but their clinical usefulness has been limited. Here we report the thermal enhancement of cytotoxicity of two…”
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Site-Selective Growth of AgPd Nanodendrite-Modified Au Nanoprisms: High Electrocatalytic Performance for CO2 Reduction by Shan, Changsheng, Martin, Erin T, Peters, Dennis G, Zaleski, Jeffrey M

“…Environmental impacts of continued CO2 production have led to an increased need for new methods of CO2 removal and energy development. Nanomaterials are of…”
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Synthesis and Structural Characterization of Porphyrinic Enediynes:  Geometric and Electronic Effects on Thermal and Photochemical Reactivity by Chandra, Tilak, Kraft, Brian J., Huffman, John C., Zaleski, Jeffrey M.

“…We report the preparation of [5,10,15,20-tetraphenyl-2,3,7,8,12,13,17,18-octakis(phenylethynyl)porphinato] complexes of Ni(II), H2, Zn(II), Mg(II), and Cu(II),…”
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Designing Synergistic Nanocatalysts for Multiple Substrate Activation: Interlattice Ag–Fe3O4 Hybrid Materials for CO2‑Inserted Lactones by Rajesh, U. Chinna, Losovyj, Yaroslav, Chen, Chun-Hsing, Zaleski, Jeffrey M

“…Multimetallic architectures that combine chemically diverse materials to affect tandem reactions within a single scaffold drive future nanocatalyst…”
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The Outliers: Metal-Mediated Radical Reagents for Biological Substrate Degradation by Porter, Meghan R, Walker, Joan M, Zaleski, Jeffrey M

“…Conspectus The predictable and controllable interaction of small organic or peptidic molecules with biological substrates is the primary reason most…”
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Anion Control of Lanthanoenediyne Cyclization by Kirschner, Krystyna M, Ratvasky, Stephen C, Pink, Maren, Zaleski, Jeffrey M

“…A suite of lanthanoenediyne complexes of the form Ln­(macrocycle)­X3 (Ln = La3+, Ce3+, Eu3+, Gd3+, Tb3+, Lu3+; X = NO3 –, Cl–, OTf–) was prepared by utilizing…”
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Metal−Ligand Charge-Transfer-Promoted Photoelectronic Bergman Cyclization of Copper Metalloenediynes:  Photochemical DNA Cleavage via C-4‘ H-Atom Abstraction by Benites, Pedro J, Holmberg, Rebecca C, Rawat, Diwan S, Kraft, Brian J, Klein, Lee J, Peters, Dennis G, Thorp, H. Holden, Zaleski, Jeffrey M

“…Metal-to-ligand charge-transfer (MLCT) photolyses (λ ≥ 395 nm) of copper complexes of cis-1,8-bis(pyridin-3-oxy)oct-4-ene-2,6-diyne (bpod, 1), [Cu(bpod)2]PF6…”
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Non-Enzymatic Remodeling of Fibrin Biopolymers via Photothermally Triggered Radical-Generating Nanoparticles by Walker, Joan M, Zaleski, Jeffrey M

“…Thrombosis is a hallmark of several chronic diseases leading to potentially fatal heart attacks and strokes. Frontline interventions include intravenous…”
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Magnetically Triggered Radical-Generating Fe3O4 Nanoparticles for Biopolymer Restructuring: Application to the Extracellular Matrix by Walker, Joan M, Zaleski, Jeffrey M

“…Halting cancer progression by altering the tumor microenvironment is an exciting new frontier in oncology. One target for new therapies is the structural…”
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UDFT and MCSCF Descriptions of the Photochemical Bergman Cyclization of Enediynes by Clark, Aurora E, Davidson, Ernest R, Zaleski, Jeffrey M

“…Several singlet and triplet potential energy surfaces (PES) for the Bergman cyclization of cis-1,5-hexadiyne-3-ene (1a) have been computed by UDFT, CI, CASCI,…”
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Enhancement of Cytotoxicity of Enediyne Compounds by Hyperthermia: Effects of Various Metal Complexes on Tumor Cells by Garrett, Joy E., Metzger, Erin, Schmitt, Katelyn, Soto, Sarai, Northern, Samantha, Kryah, Laura, Irfan, Misbah, Rice, Susan, Brown, Mary, Zaleski, Jeffrey M., Dynlacht, Joseph R.

“…Enediyne natural products are a class of compounds that were recognized for their potential as chemotherapeutic agents many years ago, but found to be highly…”
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Reactivity of the Hydrido/Nitrosyl Radical MHCl(NO)(CO)(PiPr3)2, M = Ru, Os by Marchenko, Alexei V, Vedernikov, Andrei N, Dye, David F, Pink, Maren, Zaleski, Jeffrey M, Caulton, Kenneth G

“…The reaction of equimolar NO with the 16 electron molecule RuHCl(CO)L2 (L = PiPr3) proceeds, via a radical adduct RuHCl(CO)(NO) L2, onward to form…”
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Utilizing Redox-Mediated Bergman Cyclization toward the Development of Dual-Action Metalloenediyne Therapeutics by Lindahl, Sarah E, Park, Hyunsoo, Pink, Maren, Zaleski, Jeffrey M

“…Reaction of 2 equiv of 1,2-bis((diphenyl­phosphino)ethynyl)benzene (dppeb, 1) with Pt(cod)Cl2 followed by treatment with N2H4 yields the reduced Pt(0)…”
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