Search Results - "Zaknoen, S"

Apricoxib upregulates 15-PGDH and PGT in tobacco-related epithelial malignancies by St John, M A, Wang, G, Luo, J, Dohadwala, M, Hu, D, Lin, Y, Dennis, M, Lee, J M, Elashoff, D, Lawhon, T, Zaknoen, S L, Burrows, F J, Dubinett, S M

“…Background: Despite focused research in conventional therapies and considerable advances in the understanding of the molecular carcinogenesis of head and neck…”
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Multicenter phase II trial of temozolomide in patients with glioblastoma multiforme at first relapse by Brada, M., Hoang-Xuan, K., Rampling, R., Dietrich, P-Y., Dirix, L. Y., Macdonald, D., Heimans, J. J., Zonnenberg, B. A., Bravo-Marques, J. M., Henriksson, R., Stupp, R., Yue, N., Bruner, J., Dugan, M., Rao, S., Zaknoen, S.

“…Background: Recurrent glioblastoma multiforme (GBM) is resistant to most therapeutic endeavors, with low response rates and survival rarely exceeding six…”
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Phase I study of temozolamide (TMZ) combined with procarbazine (PCB) in patients with gliomas by NEWLANDS, E. S, FOSTER, T, ZAKNOEN, S

“…Temozolomide (TMZ) is an oral alkylating agent with a good safety profile and proven efficacy in the treatment of malignant glioma. Procarbazine (PCB) has been…”
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A phase II trial of farnesyl protein transferase inhibitor SCH 66336, given by twice-daily oral administration, in patients with metastatic colorectal cancer refractory to 5-fluorouracil and irinotecan by Sharma, S., Kemeny, N., Kelsen, D. P., Ilson, D., O’Reilly, E., Zaknoen, S., Baum, C., Statkevich, P., Hollywood, E., Zhu, Y., Saltz, L. B.

“…Background: ras genes encode Ras proteins that are important for signal transduction in cancer cells. Farnesyl protein transferase (FPTase) is an enzyme that…”
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78 TG02, a multi-kinase inhibitor with potent single agent and chemosensitization activity against solid tumors by Burrows, F.J, Goh, K.C, Novotny-Diermayr, V, Hart, S, Tan, Y.C, Loh, Y.K, Cheatham, L.A, Meshaw, K.R, Zaknoen, S, Wood, J

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537P A phase I/II study of oral chk1 inhibitor LY2880070 in combination with low-dose gemcitabine in patients with advanced or metastatic ovarian cancer by Miller, W.H., Shields, A.F., Provencher, D., Gilbert, L., Shapiro, G., Oza, A.M., Spratlin, J., Lheureux, S., Bhat, G., Salvador, S., Nunes, P., Lau, S., Weiner, I., Keene, J., Zaknoen, S., Smith, P., Stille, J., Vincett, D., Chu, Q.S-C.

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Immunoregulatory cell dysfunction in chronic B-cell leukemias by Zaknoen, S L, Kay, N E

“…Chronic B-cell malignancies are routinely characterized as B-cell clonal diseases that have signs and symptoms primarily related to the continuing expansion of…”
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A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse by YUNG, W. K. A, ALBRIGHT, R. E, GLANTZ, M, GREENBERG, H, SELKER, R. G, VICK, N. A, RAMPLING, R, FRIEDMAN, H, PHILLIPS, P, BRUNER, J, YUE, N, OSOBA, D, OLSON, J, ZAKNOEN, S, LEVIN, V. A, FREDERICKS, R, FINK, K, PRADOS, M. D, BRADA, M, SPENCE, A, HOHL, R. J, SHAPIRO, W

“…A randomized, multicentre, open-label, phase II study compared temozolomide (TMZ), an oral second-generation alkylating agent, and procarbazine (PCB) in 225…”
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Phase I study of Gliadel wafers plus temozolomide in adults with recurrent supratentorial high-grade gliomas by Gururangan, S, Cokgor, L, Rich, J N, Edwards, S, Affronti, M L, Quinn, J A, Herndon, 2nd, J E, Provenzale, J M, McLendon, R E, Tourt-Uhlig, S, Sampson, J H, Stafford-Fox, V, Zaknoen, S, Early, M, Friedman, A H, Friedman, H S

“…Both Gliadel wafers [1,3-bis(2-chloroethyl)-1-nitrosourea] and temozolomide (TEMO) have been shown in independent studies to prolong survival of patients with…”
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Multicenter Phase II Trial of Temozolomide in Patients With Anaplastic Astrocytoma or Anaplastic Oligoastrocytoma at First Relapse by Yung, W.K. Alfred, Prados, Michael D., Yaya-Tur, Ricardo, Rosenfeld, Steven S., Brada, Michael, Friedman, Henry S., Albright, Robert, Olson, Jeffrey, Chang, Susan M., O'Neill, Alison M., Friedman, Allan H., Bruner, Janet, Yue, Nancy, Dugan, Margaret, Zaknoen, Sara, Levin, Victor A.

“…PURPOSE: To determine the antitumor efficacy and safety profile of temozolomide in patients with malignant astrocytoma at first relapse. PATIENTS AND METHODS:…”
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Phase II Trial of Temozolomide in Patients With Progressive Low-Grade Glioma by QUINN, Jennifer A, REARDON, David A, AVGEROPOULOS, Nicholas, FINLAY, Jonathan, TOURT-UHLIG, Sandra, AFFRONTI, Mary Lou, EVANS, Brandon, STAFFORD-FOX, Valerie, ZAKNOEN, Sara, FRIEDMAN, Henry S, FRIEDMAN, Allan H, RICH, Jeremy N, SAMPSON, John H, PROVENZALE, James M, MCLENDON, Roger E, GURURANGAN, Sridharan, BIGNER, Darell D, HERNDON, James E

“…Temozolomide (Temodar; Schering-Plough Corp, Kenilworth, NJ) is an imidazole tetrazinone that undergoes chemical conversion to the active methylating agent…”
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Phase II study of the farnesyltransferase inhibitor lonafarnib with paclitaxel in patients with taxane‐refractory/resistant nonsmall cell lung carcinoma by Kim, Edward S., Kies, Merrill S., Fossella, Frank V., Glisson, Bonnie S., Zaknoen, Sara, Statkevich, Paul, Munden, Reginald F., Summey, Carmen, Pisters, Katherine M.W., Papadimitrakopoulou, Vali, Tighiouart, Mourad, Rogatko, Andre, Khuri, Fadlo R.

“…BACKGROUND The authors evaluated the safety, tolerability, and efficacy of treatment using lonafarnib, a novel farnesyltransferase inhibitor (FTI), in…”
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Apricot-l: Results of a biomarker-based phase II randomized placebo-controlled study of apricoxib in combination with erlotinib in non-small cell lung cancer (NSCLC) patients by Gitlitz, B. J., Bernstein, E. D., Keogh, G. P., Santos, E. S., Otterson, G. A., Milne, G., Syto, M., Zaknoen, S. L.

“…Abstract only…”
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APRICoT-P: A phase II randomized placebo controlled study of apricoxib, a potent COX-2 inhibitor in combination with erlotinib and gemcitabine in pancreatic cancer patients by Keogh, G. P., Langdon, R. M., Stella, P. J., Manges, R., Chay, C. H., Looper, E., Zaknoen, S. L.

“…Abstract only…”
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B-chronic lymphocytic leukemia cells contain both endogenous kappa immunoglobulin mRNA and critical immunoglobulin gene activation transcription factors by Zaknoen, S L, Christian, S L, Suen, R, Van Ness, B, Kay, N E

“…B-cell chronic lymphocytic leukemia (B-CLL) is a hematologic malignancy characterized by the proliferation and accumulation of mature-looking B lymphocytes…”
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Infectious complications and immunodeficiency in patients with human T-cell lymphotropic virus I-associated adult T-cell leukemia/lymphoma by White, J D, Zaknoen, S L, Kasten-Sportès, C, Top, L E, Navarro-Roman, L, Nelson, D L, Waldmann, T A

“…Adult T-cell leukemia/lymphoma (ATL) is a malignancy of mature T-cells occurring in patients infected with the human T-cell lymphotropic virus-I. These…”
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TG02: A novel, multi-kinase inhibitor with potent activity against solid tumors by Burrows, F., Goh, K., Novotny-Diermayr, V., Hart, S., Hentze, H., Goh, M., Tan, Y., Cheetham, L., Zaknoen, S. L., Wood, J.

“…Abstract only…”
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Phase 1 study of temozolamide (TMZ) combined with procarbazine (PCB) in patients with gliomas by Newlands, E S, Foster, T, Zaknoen, S

“…Temozolomide (TMZ) is an oral alkylating agent with a good safety profile and proven efficacy in the treatment of malignant glioma. Procarbazine (PCB) has been…”
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TG01, a new potent COX-2 inhibitor in combination with erlotinib in metastatic or recurrent non-small cell lung cancer (NSCLC) patients: A phase 1 study by Reckamp, K. L., Patel, R., Chen, L., Gitlitz, B. J., Davies, A. M., Jezior, D., Zaknoen, S.

“…Abstract only…”
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Phase I trial of patupilone plus carboplatin in patients with advanced cancer by Gore, M., Kaye, S., Oza, A., Keyzor, C., Pyle, L., Pereno, R., Sklenar, I., Zaknoen, S., Johri, A.

“…Abstract only…”
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