Combination therapeutic options in the treatment of the luteal phase deficiency

Luteal phase deficiency (LPD) is described as a condition of insufficient progesterone exposure to maintain a regular secretory endometrium and allow for normal embryo implantation and growth. There is evidence that both follicular and luteal phase abnormalities can result in LPD cycles. The aim of...

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Published in:	Gynecological endocrinology Vol. 33; no. sup1; pp. 1 - 4
Main Authors:	Orazov, M. R., Radzinskiy, V. E., Nosenko, E. N., Khamoshina, M. B., Lebedeva, M. G., Tokaeva, E. S., Barsegyan, L. K., Novginov, D. S., Zakirova, Y. R., Minayeva, A. V.
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 22-12-2017
Subjects:	Luteal phase deficiency progesterone insufficiency reproductive age progesterone insufficiency Luteal phase deficiency reproductive age
Online Access:	Get full text
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Summary:	Luteal phase deficiency (LPD) is described as a condition of insufficient progesterone exposure to maintain a regular secretory endometrium and allow for normal embryo implantation and growth. There is evidence that both follicular and luteal phase abnormalities can result in LPD cycles. The aim of this randomized prospective noncomparative study is to evaluate the effectiveness of combination therapy in patients with LPD. This prospective study included 35 women of the reproductive age. They were diagnosed with the LPD with sonographically and laboratory-verified methods. The age of patients was 36 ± 0.46 years. The results of the study sonographically demonstrated an increase in the diameter of the corpus luteum from 1.36 ± 0.32 (initially) to 2.16 ± 0.21 mm after combination therapy. In addition, there was a statistically significant increase in the level of estrogens and progesterone in the corresponding phases of the menstrual cycle. Thus, the combination therapy for patients with LPD contributes to the recovery of cyclic events in the hypothalamic-pituitary-gonadal system, which determines the restoration of the endocrine function of the ovaries and promotes adequate secretory rearrangement of the endometrium in women of reproductive age.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0951-3590 1473-0766
DOI:	10.1080/09513590.2017.1399695