Search Results - "Zaki, Yosif"

Creating Space for Synaptic Formation—A New Role for Microglia in Synaptic Plasticity by Zaki, Yosif, Cai, Denise J.

“…Memory formation is thought to occur in the brain through dynamic remodeling of the synaptic architecture between neurons. The cellular mechanisms underlying…”
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Cellular and oscillatory substrates of fear extinction learning by Davis, Patrick, Zaki, Yosif, Maguire, Jamie, Reijmers, Leon G

“…Davis et al . report that fear memories can be critically regulated by parvalbumin-expressing interneurons in the basolateral amygdala. Silencing these…”
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Drift of neural ensembles driven by slow fluctuations of intrinsic excitability by Delamare, Geoffroy, Zaki, Yosif, Cai, Denise J, Clopath, Claudia

“…Representational drift refers to the dynamic nature of neural representations in the brain despite the behavior being seemingly stable. Although drift has been…”
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Minian, an open-source miniscope analysis pipeline by Dong, Zhe, Mau, William, Feng, Yu, Pennington, Zachary T, Chen, Lingxuan, Zaki, Yosif, Rajan, Kanaka, Shuman, Tristan, Aharoni, Daniel, Cai, Denise J

“…Miniature microscopes have gained considerable traction for in vivo calcium imaging in freely behaving animals. However, extracting calcium signals from raw…”
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Artificially Enhancing and Suppressing Hippocampus-Mediated Memories by Chen, Briana K., Murawski, Nathen J., Cincotta, Christine, McKissick, Olivia, Finkelstein, Abby, Hamidi, Anahita B., Merfeld, Emily, Doucette, Emily, Grella, Stephanie L., Shpokayte, Monika, Zaki, Yosif, Fortin, Amanda, Ramirez, Steve

“…Emerging evidence indicates that distinct hippocampal domains differentially drive cognition and emotion [1, 2]; dorsal regions encode spatial, temporal, and…”
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Reactivating hippocampal-mediated memories during reconsolidation to disrupt fear by Grella, Stephanie L., Fortin, Amanda H., Ruesch, Evan, Bladon, John H., Reynolds, Leanna F., Gross, Abby, Shpokayte, Monika, Cincotta, Christine, Zaki, Yosif, Ramirez, Steve

“…Memories are stored in the brain as cellular ensembles activated during learning and reactivated during retrieval. Using the Tet-tag system in mice, we label…”
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Development and cadherin-mediated control of prefrontal corticostriatal projections in mice by Mesías, Roxana E., Zaki, Yosif, Guevara, Christopher A., Friedman, Lauren G., Hussein, Ayan, Therrien, Karen, Magee, Alexandra R., Tzavaras, Nikolaos, Del Valle, Pamela, Baxter, Mark G., Huntley, George W., Benson, Deanna L.

“…Action-outcome associations depend on prefrontal cortex (PFC) projections to the dorsal striatum. To assess how these projections form, we measured PFC axon…”
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Memory engram stability and flexibility by Zaki, Yosif, Cai, Denise J.

“…Many studies have shown that memories are encoded in sparse neural ensembles distributed across the brain. During the post-encoding period, often during sleep,…”
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Drift of neural ensembles driven by slow fluctuations of intrinsic excitability by Delamare, Geoffroy, Zaki, Yosif, Cai, Denise J, Clopath, Claudia

“…Representational drift refers to the dynamic nature of neural representations in the brain despite the behavior being seemingly stable. Although drift has been…”
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Aversive Experience Drives Offline Ensemble Reactivation to Link Memories Across Days by Zaki, Yosif

“…Memories are encoded in neural ensembles during learning and stabilized by post-learning reactivation. Integrating recent experiences into existing memories…”
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Hippocampus and amygdala fear memory engrams re-emerge after contextual fear relapse by Zaki, Yosif, Mau, William, Cincotta, Christine, Monasterio, Amy, Odom, Emma, Doucette, Emily, Grella, Stephanie L, Merfeld, Emily, Shpokayte, Monika, Ramirez, Steve

“…The formation and extinction of fear memories represent two forms of learning that each engage the hippocampus and amygdala. How cell populations in these…”
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Social reactivation of fear engrams enhances memory recall by Finkelstein, Abby Basya, Leblanc, Héloïse, Cole, Rebecca H, Gallerani, Troy, Vieira, Anahita, Zaki, Yosif, Ramirez, Steve

“…For group-living animals, the social environment provides salient experience that can weaken or strengthen aspects of cognition such as memory recall. Although…”
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The role of intrinsic excitability in the evolution of memory: Significance in memory allocation, consolidation, and updating by Chen, Lingxuan, Cummings, Kirstie A., Mau, William, Zaki, Yosif, Dong, Zhe, Rabinowitz, Sima, Clem, Roger L., Shuman, Tristan, Cai, Denise J.

“…•Neuronal intrinsic excitability contributes to different phases of a memory’s evolution.•Intrinsic excitability promotes both the stability and flexibility of…”
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Ensemble-specific deficit in neuronal intrinsic excitability in aged mice by Chen, Lingxuan, Francisco, Taylor R., Baggetta, Austin M., Zaki, Yosif, Ramirez, Steve, Clem, Roger L., Shuman, Tristan, Cai, Denise J.

“…With the prevalence of age-related cognitive deficits on the rise, it is essential to identify cellular and circuit alterations that contribute to age-related…”
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Offline ensemble co-reactivation links memories across days by Zaki, Yosif, Pennington, Zachary T., Morales-Rodriguez, Denisse, Bacon, Madeline E., Ko, BumJin, Francisco, Taylor R., LaBanca, Alexa R., Sompolpong, Patlapa, Dong, Zhe, Lamsifer, Sophia, Chen, Hung-Tu, Carrillo Segura, Simón, Christenson Wick, Zoé, Silva, Alcino J., Rajan, Kanaka, van der Meer, Matthijs, Fenton, André, Shuman, Tristan, Cai, Denise J.

“…Abstract Memories are encoded in neural ensembles during learning 1–6 and are stabilized by post-learning reactivation 7–17 . Integrating recent experiences…”
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