Search Results - "Zakharova, M M"

Monoclonal Antibodies in Neurology: Current State and Future Development by Zakharova, M. N.

“…Monoclonal antibodies are one of the fastest growing areas of specific therapy for cancer, infectious, autoimmune, and demyelinating diseases. The main targets…”
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High‐frequency repetitive transcranial magnetic stimulation and intermittent theta‐burst stimulation for spasticity management in secondary progressive multiple sclerosis by Korzhova, J., Bakulin, I., Sinitsyn, D., Poydasheva, A., Suponeva, N., Zakharova, M., Piradov, M.

“…Background and purpose The spasticity phenomenon is a significant factor in the development of disability. Repetitive transcranial magnetic stimulation (rTMS)…”
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Specific Features of the Soil Cover of Recreation Areas in Leningrad Oblast by Zakharova, M. K., Morgach, Y. R.

“…Studies of soils and soil cover of recreation zones were carried out in Leningrad oblast in areas located near various water bodies: rivers, lakes, the Gulf of…”
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Mechanisms of Neurodegeneration in Multiple Sclerosis by Eliseeva, D. D., Zakharova, M. N.

“…Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), which leads to the formation of foci of primary demyelination in…”
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The Development of Various Speech Components and Their Relations with the State of the Brain Executive Functions in Senior Preschool Age by Zakharova, M. N., Agris, A. R.

“…The brain executive functions (EFs) are crucial for various aspects of child development, as they stipulate control of cognitive processes and behavior. Speech…”
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Construction of Expression Vectors for Efficient Production of Recombinant Proteins in E. coli for the Development of Therapeutic Drugs by Zakharova, M. V., Mubarakshina, E. K., Nagornykh, M. O.

“…When developing vaccines and immunotherapeutic and enzymatic drugs, it is usually necessary to obtain a functional protein preparation, which can later be used…”
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Structural Elements of DNA and RNA Eukaryotic Expression Vectors for In Vitro and In Vivo Genome Editor Delivery by Zagoskin, A. A., Zakharova, M. V., Nagornykh, M. O.

“…Gene editing with programmable nucleases opens new perspectives in important practice areas, such as healthcare and agriculture. The most challenging problem…”
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Multiple Sclerosis Is Associated with Immunoglobulin Germline Gene Variation of Transitional B Cells by Lomakin, Y A, Ovchinnikova, L A, Zakharova, M N, Ivanova, M V, Simaniv, T O, Kabilov, M R, Bykova, N A, Mukhina, V S, Kaminskaya, A N, Tupikin, A E, Zakharova, M Y, Favorov, A V, Illarioshkin, S N, Belogurov, A A, Gabibov, A G

“…The regulatory functions of the B-cell compartment play an important role in the development and suppression of the immune response. Disruption of their…”
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Synaptic Dysfunction in Epilepsy by Zaitsev, А. V., Amakhin, D. V., Dyomina, A. V., Zakharova, M. V., Ergina, J. L., Postnikova, T. Y., Diespirov, G. P., Magazanik, L. G.

“…Epilepsy is one of the prevalent cerebral diseases, and despite intensive research of this pathology for many years, modern medicine cannot effectively control…”
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Thymulin, free or bound to PBCA nanoparticles, protects mice against chronic septic inflammation by Novoselova, Elena G, Lunin, Sergey M, Glushkova, Olga V, Khrenov, Maxim O, Parfenyuk, Svetlana B, Zakharova, Nadezhda M, Fesenko, Evgeny E

“…In the present work, we aimed to study the effects of free and polybutylcyanoacrylate nanoparticle-bound thymulin on immune cell activity in mice with chronic…”
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A pharmacological composition for induction of a reversible torpor-like state and hypothermia in rats by Zakharova, Nadezhda M., Tarahovsky, Yury S., Fadeeva, Irina S., Komelina, Natalia P., Khrenov, Maxim O., Glushkova, Olga V., Prokhorov, Dmitry A., Kutyshenko, Viktor P., Kovtun, Anatoly L.

“…To initiate a state of artificial torpor we suggested a pharmacological multi-targeting strategy for simulation of the physiological pattern of natural…”
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The Effectiveness of Detecting Thematic Relations of Objects in 3–6 Year Old Children by Kurganskii, A. V., Zakharova, M. N., Kayumov, D. D., Antonova, S. Yu

“…In this study, the ability of preschoolers aged 3–6 to detect and understand the thematic connections of objects was assessed. Children (95 children; 53 girls…”
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Structural and functional characterization of two-domain laccase from Streptomyces viridochromogenes by Trubitsina, L.I., Tishchenko, S.V., Gabdulkhakov, A.G., Lisov, A.V., Zakharova, M.V., Leontievsky, A.A.

“…Laccase (EC 1.10.3.2) is one of the most common copper-containing oxidases found in many organisms and catalyses oxidation of primarily phenolic compounds by…”
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Anakinra Promotes M2 Microglia Activation during the Latent Phase of the Lithium-Pilocarpine Model of Temporal Lobe Epilepsy by Zakharova, M. V., Dyomina, A. V., Kovalenko, A. A., Zubareva, O. E., Ischenko, A. M., Zaitsev, A. V.

“…Astrocytes, microglia, and their polarization are thought to contribute to the progression of epilepsy. One of the processes affecting polarization is…”
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The Reference Gene Validation in the Brain of Rats during Antioxidant and Anti-Inflammatory Treatment in the Lithium-Pilocarpine Model of Temporal Epilepsy by Schwarz, A. P., Dyomina, A. V., Zakharova, M. V., Kovalenko, A. A., Gryaznova, M. O., Ischenko, A. M., Zaitsev, A. V.

“…Reverse transcription combined with quantitative (real-time) polymerase chain reaction (RT-qPCR) is the gold standard for assessing gene expression, but…”
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The Level of Anti-Viral Antigen-Specific Antibodies to EBNA-1 in the Serum of MS Patients Does not Depend on the Severity of the Disease by Ovchinnikova, L. A., Dzhelad, S. S., Simaniv, T. O., Zakharova, M. N., Gabibov, A. G., Lomakin, Y. A.

“…Multiple sclerosis (MS) is an autoimmune neurodegenerative disease leading to inevitable disability and primarily affecting the young and middle-aged…”
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Exploring the Split-Hand Phenomenon in ALS with Motor unit Number Index (MUNIX) by Abramova, A. A., Broutian, A. G., Zakharova, M. N.

“…Split-hand phenomenon in amyotrophic lateral sclerosis (ALS) is characterized by uneven progression of muscle weakness in the intrinsic hand muscles, with…”
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Synthesis, Cytotoxicity and Antiviral Activity Against Vaccinia Virus of 2-(3-Coumarinyl)-1-Hydroxyimidazoles by Nikitina, Polina A, Zakharova, Anastasia M, Serova, Olga A, Bormotov, Nikolay I, Mazurkov, Oleg Y, Shishkina, Larisa N, Koldaeva, Tatiana Y, Basanova, Elizaveta I, Perevalov, Valery P

“…In 1980, smallpox became the first viral disease eradicated through vaccination. After the termination of the Smallpox Eradication Program, the global…”
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Effect of Anakinra on the Gene Expression of Receptors Activated by the Peroxisome Proliferator in the Rat Brain in the Lithium Pilocarpine Model of Epilepsy by Roginskaya, A. I., Dyomina, A. V., Kovalenko, A. A., Zakharova, M. V., Schwarz, A. P., Melik-Kasumov, T. B., Zubareva, O. E.

“…The role of neuroinflammation in the mechanisms of epileptogenesis has been widely discussed in recent years. One of the factors influencing inflammatory…”
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The Contribution of Major Histocompatibility Complex Class II Genes to an Association with Autoimmune Diseases by Zakharova, M Yu, Belyanina, T A, Sokolov, A V, Kiselev, I S, Mamedov, A E

“…Genetic studies of patients with autoimmune diseases have shown that one of the most important roles in the developing of these diseases is played by a cluster…”
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