Search Results - "Zakhaleva, Victoria"
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An immunogenic WT1-derived peptide that induces T cell response in the context of HLA-A02:01 and HLA-A24:02 molecules
Published in Oncoimmunology (01-02-2017)“…The Wilms' tumor oncogene protein (WT1) is a highly validated tumor antigen for immunotherapy. WT1-targeted immunotherapy has been extensively explored in…”
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Identification of a human cyclin D1-derived peptide that induces human cytotoxic CD4 T cells
Published in PloS one (25-08-2009)“…Cyclin D1 is over-expressed in various human tumors and therefore can be a potential oncogenic target antigen. However, only a limited number of T cell…”
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Targeting the intracellular WT1 oncogene product with a therapeutic human antibody
Published in Science translational medicine (13-03-2013)“…The Wilms tumor 1 (WT1) oncoprotein is an intracellular, oncogenic transcription factor that is overexpressed in a wide range of leukemias and solid cancers…”
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Vaccination with synthetic analog peptides derived from WT1 oncoprotein induces T-cell responses in patients with complete remission from acute myeloid leukemia
Published in Blood (15-07-2010)“…A pilot study was undertaken to assess the safety, activity, and immunogenicity of a polyvalent Wilms tumor gene 1 (WT1) peptide vaccine in patients with acute…”
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Therapeutic Efficacy of an Fc-Enhanced TCR-like Antibody to the Intracellular WT1 Oncoprotein
Published in Clinical cancer research (01-08-2014)“…RMFPNAPYL (RMF), a Wilms' tumor gene 1 (WT1)-derived CD8 T-cell epitope presented by HLA-A*02:01, is a validated target for T-cell-based immunotherapy. We…”
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WT1 peptide vaccinations induce CD4 and CD8 T cell immune responses in patients with mesothelioma and non-small cell lung cancer
Published in Cancer Immunology, Immunotherapy (01-10-2010)“…Background The transcription factor, WT1, is highly overexpressed in malignant pleural mesothelioma (MPM) and immunohistochemical stains for WT1 are used…”
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A Bi-Specific T Cell Engaging Monoclonal Antibody (mAb) Derived From a TCR-Like Mab Specific For WT1/HLA-A0201 (ESK-BiTE) Shows a Potent Activity Against Human AML and Ph+ ALL In Mouse Models
Published in Blood (15-11-2013)“…The Wilms' tumor oncogene protein (WT1) is an intracellular, oncogenic transcription factor that is over-expressed in a wide range of leukemias and solid…”
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