Search Results - "Zakelj, Simon"

A review of methods for solubility determination in biopharmaceutical drug characterization by Veseli, Ardita, Žakelj, Simon, Kristl, Albin

“…The significance of thermodynamic solubility in biopharmaceutical compound or drug characterization as well as the importance of having methods that accurately…”
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Suitability of RPMI 2650 cell models for nasal drug permeability prediction by Sibinovska, Nadica, Žakelj, Simon, Kristan, Katja

“…[Display omitted] The RPMI 2650 cell line has been a subject of evaluation as a physiological and pharmacological model of the nasal epithelial barrier…”
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The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity by Košak, Urban, Brus, Boris, Knez, Damijan, Žakelj, Simon, Trontelj, Jurij, Pišlar, Anja, Šink, Roman, Jukič, Marko, Živin, Marko, Podkowa, Adrian, Nachon, Florian, Brazzolotto, Xavier, Stojan, Jure, Kos, Janko, Coquelle, Nicolas, Sałat, Kinga, Colletier, Jacques-Philippe, Gobec, Stanislav

“…The enzymatic activity of butyrylcholinesterase (BChE) in the brain increases with the progression of Alzheimer’s disease, thus classifying BChE as a promising…”
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Suitability and functional characterization of two Calu-3 cell models for prediction of drug permeability across the airway epithelial barrier by Sibinovska, Nadica, Žakelj, Simon, Roškar, Robert, Kristan, Katja

“…[Display omitted] The Calu-3 cell line has been largely investigated as a physiological and pharmacological model of the airway epithelial barrier. Its…”
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Stereoselective Activity of 1‑Propargyl-4-styrylpiperidine-like Analogues That Can Discriminate between Monoamine Oxidase Isoforms A and B by Knez, Damijan, Colettis, Natalia, Iacovino, Luca G, Sova, Matej, Pišlar, Anja, Konc, Janez, Lešnik, Samo, Higgs, Josefina, Kamecki, Fabiola, Mangialavori, Irene, Dolšak, Ana, Žakelj, Simon, Trontelj, Jurij, Kos, Janko, Binda, Claudia, Marder, Mariel, Gobec, Stanislav

“…The resurgence of interest in monoamine oxidases (MAOs) has been fueled by recent correlations of this enzymatic activity with cardiovascular, neurological,…”
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Applicability of RPMI 2650 and Calu-3 Cell Models for Evaluation of Nasal Formulations by Sibinovska, Nadica, Žakelj, Simon, Trontelj, Jurij, Kristan, Katja

“…The RPMI 2650 and Calu-3 cell lines have been previously evaluated as models of the nasal and airway epithelial barrier, and they have demonstrated the…”
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Treatment of canine cognitive dysfunction with novel butyrylcholinesterase inhibitor by Zakošek Pipan, Maja, Prpar Mihevc, Sonja, Štrbenc, Malan, Košak, Urban, German Ilić, Ilija, Trontelj, Jurij, Žakelj, Simon, Gobec, Stanislav, Pavlin, Darja, Majdič, Gregor

“…Canine cognitive dysfunction (CCD) is common in aged dogs and has many similarities with Alzheimer’s disease. Unfortunately, like Alzheimer’s disease, CCD…”
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Development of an in-vivo active reversible butyrylcholinesterase inhibitor by Košak, Urban, Brus, Boris, Knez, Damijan, Šink, Roman, Žakelj, Simon, Trontelj, Jurij, Pišlar, Anja, Šlenc, Jasna, Gobec, Martina, Živin, Marko, Tratnjek, Larisa, Perše, Martina, Sałat, Kinga, Podkowa, Adrian, Filipek, Barbara, Nachon, Florian, Brazzolotto, Xavier, Więckowska, Anna, Malawska, Barbara, Stojan, Jure, Raščan, Irena Mlinarič, Kos, Janko, Coquelle, Nicolas, Colletier, Jacques-Philippe, Gobec, Stanislav

“…Alzheimer’s disease (AD) is characterized by severe basal forebrain cholinergic deficit, which results in progressive and chronic deterioration of memory and…”
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How Azide Ion/Hydrazoic Acid Passes Through Biological Membranes: An Experimental and Computational Study by Hartl, Simona Lojevec, Žakelj, Simon, Dolenc, Marija Sollner, Smrkolj, Vladimir, Mavri, Janez

“…Hydrazoic acid (HN 3 ) and its deprotonated form azide ion (N 3 − ) (AHA) are toxic because they inhibit the cytochrome c oxidase complex IV (CoX IV) embedded…”
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The effect of lipid composition and liposome size on the release properties of liposomes-in-hydrogel by Hurler, Julia, Žakelj, Simon, Mravljak, Janez, Pajk, Stane, Kristl, Albin, Schubert, Rolf, Škalko-Basnet, Nataša

“…To study the release of liposome-associated drugs into hydrogels, we designed and synthesized two pH-sensitive rhodamine derivatives to use as model compounds…”
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Biopharmaceutical classification of desloratadine - not all drugs are classified the easy way by Berginc, Katja, Sibinovska, Nadica, Žakelj, Simon, Trontelj, Jurij, Legen, Igor

“…The biopharmaceutical classification of drugs was designed as a basis for bio-waivers - a mechanism with the double ethical benefit of delivering new drug…”
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Mechanical properties and drug permeability of the PA6 membranes prepared by immersion precipitation from PA6 – formic acid – water system by Aulova, Alexandra, Cvenkel, Anže, Žakelj, Simon, Planinšek, Odon, Kristl, Albin, Emri, Igor

“…The paper presents the effect of polymer solution composition on the morphology, mechanical properties and drug permeability of the asymmetric polyamide 6…”
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Indoles and 1-(3-(benzyloxy)benzyl)piperazines: Reversible and selective monoamine oxidase B inhibitors identified by screening an in-house compound library by Knez, Damijan, Hrast, Martina, Frlan, Rok, Pišlar, Anja, Žakelj, Simon, Kos, Janko, Gobec, Stanislav

“…[Display omitted] •MAO-B inhibitors were identified in the screening of the in-house compound library.•Exploration of SARs led to selective micromolar…”
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Determination of permeability coefficients of ophthalmic drugs through different layers of porcine, rabbit and bovine eyes by Loch, Christian, Zakelj, Simon, Kristl, Albin, Nagel, Stefan, Guthoff, Rudolf, Weitschies, Werner, Seidlitz, Anne

“…Comparison of permeability coefficients of lidocaine, ciprofloxacin, timolol and dexamethasone for the cornea and a multi-layer complex of porcine, bovine and…”
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8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases by Knez, Damijan, Diez-Iriepa, Daniel, Chioua, Mourad, Gottinger, Andrea, Denic, Milica, Chantegreil, Fabien, Nachon, Florian, Brazzolotto, Xavier, Skrzypczak-Wiercioch, Anna, Meden, Anže, Pišlar, Anja, Kos, Janko, Žakelj, Simon, Stojan, Jure, Sałat, Kinga, Serrano, Julia, Fernández, Ana Patricia, Sánchez-García, Aitana, Martínez-Murillo, Ricardo, Binda, Claudia, López-Muñoz, Francisco, Gobec, Stanislav, Marco-Contelles, José

“…We describe the development of quinolylnitrones (QNs) as multifunctional ligands inhibiting cholinesterases (ChEs: acetylcholinesterase and…”
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Thematic issue on drug delivery for specific populations by Grabnar, Iztok, Mrhar, Aleš

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Decreasing acidity in a series of aldose reductase inhibitors: 2-Fluoro-4-(1H-pyrrol-1-yl)phenol as a scaffold for improved membrane permeation by Chatzopoulou, Maria, Patsilinakos, Alexandros, Vallianatou, Theodosia, Prnova, Marta Soltesova, Žakelj, Simon, Ragno, Rino, Stefek, Milan, Kristl, Albin, Tsantili-Kakoulidou, Anna, Demopoulos, Vassilis J.

“…Targeting long-term diabetic complications, as well as inflammatory pathologies, aldose reductase inhibitors (ARIs) have been gaining attention over the years…”
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In vitro interactions between aged garlic extract and drugs used for the treatment of cardiovascular and diabetic patients by Berginc, Katja, Žakelj, Simon, Kristl, Albin

“…Background Disease preventing effects gained by garlic consumption have been recognized since early period of history, making commercially available garlic…”
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Correlative study of functional and structural regeneration of urothelium after chitosan-induced injury by Erman, Andreja, Kerec Kos, Mojca, Žakelj, Simon, Resnik, Nataša, Romih, Rok, Veranič, Peter

“…High transepithelial electrical resistance (TEER) demonstrates a functional permeability barrier of the normal urothelium, which is maintained by a layer of…”
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Aged Garlic Extract Stimulates P-Glycoprotein and Multidrug Resistance Associated Protein 2 Mediated Effluxes by Berginc, Katja, Žakelj, Simon, Uršič, Darko, Kristl, Albin

“…The growing concomitant consumption of drugs and herbal preparations such as garlic, and the numerous reports about the influence of herbal preparations on…”
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