Search Results - "Zakas, Lauren"

324 Allogeneic CAR T cells targeting Liv-1 for breast cancer by Zakas, Lauren, Pham, Minh, Bartle, Laura, Li, Zejun, Maeng, Kelly, Hanley, Luke, Ganpule, Avanti, Sagert, Jason, Terrett, Jonathan, Kalaitzidis, Demetrios

“…BackgroundWhile HER2 is an important target of several approved breast cancer treatments, limitations include the lower prevalence of HER2 overexpression (in…”
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274 Development of CTX112 a next generation allogeneic multiplexed CRISPR-edited CART cell therapy with disruptions of the TGFBR2 and Regnase-1 genes for improved manufacturing and potency by Kalaitzidis, Demetrios, Ghonime, Mohammed, Chain, Robert, Jaishankar, Nivedita, Settipane, Davis, Padalia, Zinkal, Zakas, Lauren, Kuppuraju, Meghna, Tetteh, Paul, Dequeant, Mary-Lee, Karnik, Sushant, Massilamany, Chandirasegaran, McEwan, Brigid, Dar, Henia, Allen, Melanie, Serwer, Laura, Nguyen, Thao, Butler-Gauthier, Melanie, Sripakdeevong, Parin, Nagar, Shashwat, Tang, Yin, Flanagan, Nicole, Huang, Elaine, Phuyal, Shashwant, Dunn, Andrew, Koch, Elizabeth, Sula, Erisa, Waldman, Jacob, Zhang, Maria Lei, Loaiza, Cristian, Thorstensen, Erin, Steiger, Keith, Schum, Katie, Urbaez, Kayla, Ma, Anna, Weaver, Annie Yang, Finch, Christopher, Cohen, Sarah, Morrow, PK, Benton, Mark, Terrett, Jonathan

“…BackgroundCTX110, a CD19-directed first-generation CRISPR-edited CAR T cell therapeutic candidate for B-cell lymphoma, has induced clinical responses and…”
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Abstract ND02: CTX112 and CTX131: Next-generation CRISPR/Cas9-engineered allogeneic (allo) CAR T cells incorporating novel edits that increase potency and efficacy in the treatment of lymphoid and solid tumors by Terrett, Jonathan A., Kalaitzidis, Demetrios, Dequeant, Mary-Lee, Karnik, Sushant, Ghonime, Mohammed, Guo, Changan, Chain, Robert, Heath, Heidi, Jaishankar, Nivedita, Yuen, Rachel, Settipane, Davis, Padalia, Zinkal, Zakas, Lauren, Kuppuraju, Meghna, Tetteh, Paul, Massilamany, Chandirasegaran, McEwan, Brigid, Leary, Glenn, Dar, Henia, Ferulo, Daniel, Allen, Melanie, Tipton, Kimberley, Serwer, Laura, Nguyen, Thao, Butler-Gauthier, Melanie, Sripakdeevong, Parin, Nagar, Shashwat D., Tang, Yin, Chaudhari, Hemangi, Flanagan, Nicole, Huang, Elaine, Phuyal, Shashwant, Koch, Elizabeth, Dunn, Andrew, Sula, Erisa, Waldman, Jacob, Loaiza, Cristian, Zhang, Maria Lei, Thorstensen, Erin, Steiger, Keith, Schum, Katie, Urbaez, Kayla, Benton, Mark, Ma, Anna, Cohen, Sarah, Weaver, Annie, Finch, Christopher, Morrow, Phuong Khanh

“…Allo CAR T cells represent an “off-the-shelf” treatment option that addresses the unmet need for immediately available, potentially curative therapies. CRISPR…”
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