Search Results - "Zak, M."

Light-Induced In Situ Transmission Electron MicroscopyDevelopment, Challenges, and Perspectives by Żak, Andrzej M.

“…Transmission electron microscopy is a basic technique used for examining matter at the highest magnification scale available. One of its most challenging…”
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Structural Biology of the Immune Checkpoint Receptor PD-1 and Its Ligands PD-L1/PD-L2 by Zak, Krzysztof M., Grudnik, Przemyslaw, Magiera, Katarzyna, Dömling, Alexander, Dubin, Grzegorz, Holak, Tad A.

“…Cancer cells can avoid and suppress immune responses through activation of inhibitory immune checkpoint proteins, such as PD-1, PD-L1, and CTLA-4. Blocking the…”
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Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1 by Guzik, Katarzyna, Zak, Krzysztof M, Grudnik, Przemyslaw, Magiera, Katarzyna, Musielak, Bogdan, Törner, Ricarda, Skalniak, Lukasz, Dömling, Alexander, Dubin, Grzegorz, Holak, Tad A

“…Blockade of the PD-1/PD-L1 immune checkpoint pathway with monoclonal antibodies has provided significant advances in cancer treatment. The antibody-based…”
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Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1 by Zak, Krzysztof M., Kitel, Radoslaw, Przetocka, Sara, Golik, Przemyslaw, Guzik, Katarzyna, Musielak, Bogdan, Dömling, Alexander, Dubin, Grzegorz, Holak, Tad A.

“…Targeting the PD-1/PD-L1 immunologic checkpoint with monoclonal antibodies has recently provided breakthrough progress in the treatment of melanoma, non-small…”
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Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1) by Zak, Krzysztof M, Grudnik, Przemyslaw, Guzik, Katarzyna, Zieba, Bartosz J, Musielak, Bogdan, Dömling, Alexander, Dubin, Grzegorz, Holak, Tad A

“…Targeting the PD-1/PD-L1 immunologic checkpoint with monoclonal antibodies has provided unprecedented results in cancer treatment in the recent years…”
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Enhancing technological prospect of nanostructured bainitic steels by the control of thermal stability of austenite by Królicka, Aleksandra, Żak, Andrzej M., Caballero, Francisca G.

“…[Display omitted] •Enhancing thermal stability allow for the industrialization of bainitic steels.•Thermal stability may be controlled by chemical composition…”
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Performance-Driven Design of Carrier Phase Differential Navigation Frameworks With Megaconstellation LEO Satellites by Khalife, Joe, Kassas, Zaher M.

“…A navigation framework with carrier phase differential measurements from megaconstellation low Earth orbit (LEO) satellite signals is developed. The…”
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Optimal Sensor Placement for Dilution of Precision Minimization Via Quadratically Constrained Fractional Programming by Khalife, Joe J., Kassas, Zaher Zak M.

“…An approach to find the global optimal solution of the dilution of precision (DOP) problem is presented. The DOP optimization problem considered assumes an…”
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Stochastic Observability and Uncertainty Characterization in Simultaneous Receiver and Transmitter Localization by Morales, Joshua J., Kassas, Zaher M.

“…The stochastic observability of simultaneous receiver and transmitter localization is studied. A mobile vehicle-mounted receiver is assumed to draw pseudorange…”
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Measurement Characterization and Autonomous Outlier Detection and Exclusion for Ground Vehicle Navigation With Cellular Signals by Maaref, Mahdi, Kassas, Zak M.

“…An autonomous measurement outlier detection and exclusion framework for ground vehicle navigation using cellular signals is developed. The ground vehicle aids…”
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Bioactive Macrocyclic Inhibitors of the PD‐1/PD‐L1 Immune Checkpoint by Magiera‐Mularz, Katarzyna, Skalniak, Lukasz, Zak, Krzysztof M., Musielak, Bogdan, Rudzinska‐Szostak, Ewa, Berlicki, Łukasz, Kocik, Justyna, Grudnik, Przemyslaw, Sala, Dominik, Zarganes‐Tzitzikas, Tryfon, Shaabani, Shabnam, Dömling, Alexander, Dubin, Grzegorz, Holak, Tad A.

“…Blockade of the immunoinhibitory PD‐1/PD‐L1 pathway using monoclonal antibodies has shown impressive results with durable clinical antitumor responses…”
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Developing the Cannabinoid Receptor 2 (CB2) pharmacopoeia: past, present, and future by Whiting, Zak M., Yin, Jiazhen, de la Harpe, Sara M., Vernall, Andrea J., Grimsey, Natasha L.

“…Cannabinoid Receptor 2 (CB2) is a G protein-coupled receptor (GPCR) with considerable, though as yet unrealised, therapeutic potential. Promising preclinical…”
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Novel Cannabinoid Receptor 2 (CB2) Low Lipophilicity Agonists Produce Distinct cAMP and Arrestin Signalling Kinetics without Bias by Sharma, Raahul, Singh, Sameek, Whiting, Zak M, Molitor, Maximilian, Vernall, Andrea J, Grimsey, Natasha L

“…Cannabinoid Receptor 2 (CB2) is a promising target for treating inflammatory diseases. We designed derivatives of 3-carbamoyl-2-pyridone and…”
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Spectrally Resolved Kinetics of Energy Transfer Within a Single Emission Band of Highly Luminescent Thick‐Shell CdSe/CdS Colloidal Quantum Dots by Zatryb, Grzegorz, Adamski, Adrian, Chrzanowski, Maciej, Banski, Mateusz, Zak, Andrzej M., Podhorodecki, Artur

“…The resonant energy transfer (ET) between quantum dots (QDs) can influence the performance of some devices, such as QD light‐emitting diodes (QLEDs). Since the…”
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Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders by Wątor, Elżbieta, Wilk, Piotr, Biela, Artur, Rawski, Michał, Zak, Krzysztof M., Steinchen, Wieland, Bange, Gert, Glatt, Sebastian, Grudnik, Przemysław

“…Hypusination is a unique post-translational modification of the eukaryotic translation factor 5A (eIF5A) that is essential for overcoming ribosome stalling at…”
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Ion implantation of tunnel junction as a method for defining the aperture of III-nitride-based micro-light-emitting diodes by Slawinska, J., Muziol, G., Siekacz, M., Turski, H., Hajdel, M., Zak, M., Feduniewicz-Zmuda, A., Staszczak, G., Skierbiszewski, C.

“…We report on III-nitride-based micro-light-emitting diodes (µLEDs) operating at 450 nm wavelength with diameters down to 2 µm. Devices with a standard LED…”
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Don't skip a beat! Critical findings in imaging studies performed in adults with congenital heart disease by Robb, Caroline, Rajput, M. Zak, Raptis, Demetrios, Bhalla, Sanjeev

“…With ongoing advances in both medical and surgical management, the population of adults with congenital heart disease (CHD) continues to grow each year and has…”
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Modulation of peroxisomal import by the PEX13 SH3 domain and a proximal FxxxF binding motif by Gaussmann, Stefan, Peschel, Rebecca, Ott, Julia, Zak, Krzysztof M., Sastre, Judit, Delhommel, Florent, Popowicz, Grzegorz M., Boekhoven, Job, Schliebs, Wolfgang, Erdmann, Ralf, Sattler, Michael

“…Import of proteins into peroxisomes depends on PEX5, PEX13 and PEX14. By combining biochemical methods and structural biology, we show that the C-terminal SH3…”
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The influence of solvent refractive index on the photoluminescence decay of thick‐shell gradient‐alloyed colloidal quantum dots investigated in a wide range of delay times by Zatryb, Grzegorz, Adamski, Adrian, Chrzanowski, Maciej, Żak, Andrzej M., Podhorodecki, Artur

“…Colloidal semiconductor quantum dots have many potential optical applications, including quantum dot light‐emitting diodes, single‐photon sources, or…”
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Regional climate model assessment of the urban land-surface forcing over central Europe by Huszar, P, Halenka, T, Belda, M, Zak, M, Sindelarova, K, Miksovsky, J

“…For the purpose of qualifying and quantifying the climate impact of cities and urban surfaces in general on climate of central Europe, the surface…”
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