Search Results - "Zajchowski, D"

Comprehensive genomic profiling of epithelial ovarian cancer by next generation sequencing-based diagnostic assay reveals new routes to targeted therapies by Ross, J.S, Ali, S.M, Wang, K, Palmer, G, Yelensky, R, Lipson, D, Miller, V.A, Zajchowski, D, Shawver, L.K, Stephens, P.J

“…Abstract Objective Targeted next generation sequencing (NGS) was evaluated for its ability to identify unanticipated targetable genomic alterations (GA) for…”
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Tid1 is a new regulator of p53 mitochondrial translocation and apoptosis in cancer by Ahn, B Y, Trinh, D L N, Zajchowski, L D, Lee, B, Elwi, A N, Kim, S -W

“…The p53 tumor suppressor protein induces apoptosis in response to genotoxic and environmental stresses. Recent studies have revealed the existence of a…”
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PI3K pathway activation and thromboembolism in ovarian clear cell carcinomas by Diaz, E, Fleming, N, Nassanian, H, Walts, A, Zajchowski, D, Orsulic, S, Walsh, C

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PI3K pathway activation, thromboembolism and survival in ovarian clear cell carcinoma by Agadjanian, H, Nassanian, H, Walts, A, Miller, C, Zajchowski, D, Karlan, B, Orsulic, S, Walsh, C

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Lipid rafts and little caves. Compartmentalized signalling in membrane microdomains by Zajchowski, Laura D, Robbins, Stephen M

“…Lipid rafts are liquid-ordered membrane microdomains with a unique protein and lipid composition found on the plasma membrane of most, if not all, mammalian…”
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Identification of gene expression profiles that predict the aggressive behavior of breast cancer cells by ZAJCHOWSKI, Deborah A, BARTHOLDI, Marty F, YAN GONG, WEBSTER, Lynn, LIU, Hsiao-Lai, MUNISHKIN, Alexander, BEAUHEIM, Catherine, HARVEY, Susan, ETHIER, Stephen P, JOHNSON, Paul H

“…With the goal of identifying genes that have an expression pattern that can facilitate the diagnosis of primary breast cancers (BCs) as well as the discovery…”
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Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER by Browman, Duncan T, Resek, Mary E, Zajchowski, Laura D, Robbins, Stephen M

“…Our laboratory was interested in characterizing the molecular composition of non-caveolar lipid rafts. Thus, we generated monoclonal antibodies to lipid raft…”
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Human Papilloma Virus DNAs Immortalize Normal Human Mammary Epithelial Cells and Reduce Their Growth Factor Requirements by Band, Vimla, Zajchowski, Deborah, Kulesa, Victoria, Sager, Ruth

“…Human papilloma virus (HPV) types 16 and 18 are most commonly associated with cervical carcinoma in patients and induce immortalization of human keratinocytes…”
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Estrogen inhibits the growth of estrogen receptor-negative, but not estrogen receptor-positive, human mammary epithelial cells expressing a recombinant estrogen receptor by ZAJCHOWSKI, D. A, SAGER, R, WEBSTER, L

“…Estrogen is essential for the growth of the normal mammary gland and most estrogen receptor (ER)-positive mammary carcinomas. To better understand the…”
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Clinical trial enrollment is associated with improved survival in recurrent ovarian cancer patients by Rimel, B., Wong, M.S., Zajchowski, D., Temkin, S.M.

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Keratins as Markers that Distinguish Normal and Tumor-Derived Mammary Epithelial Cells by Trask, Douglas K., Band, Vimla, Zajchowski, Deborah A., Yaswen, Paul, Suh, Theodore, Sager, Ruth

“…Keratin 5 (K5) mRNA and protein are shown to be expressed in normal mammary epithelial cells in culture and are absent from tumor-derived cell lines. To extend…”
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Mutation profiles of paired ovarian cancers across time by Fehniger, J., Berger, A.A., Gay, L., Elvin, J.A., Levine, D.A., Zajchowski, D.

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Induction of estrogen-regulated genes differs in immortal and tumorigenic human mammary epithelial cells expressing a recombinant estrogen receptor by Zajchowski, D A, Sager, R

“…Studies on estrogen receptor (ER)-positive human breast cancer cell lines have shown that estrogen treatment positively modulates the expression of the genes…”
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Functional Diversity of gro Gene Expression in Human Fibroblasts and Mammary Epithelial Cells by Anisowicz, Anthony, Zajchowski, Deborah, Stenman, Göran, Sager, Ruth

“…Previous studies of gro and related genes that are overexpressed in transformed fibroblasts suggest that gro may encode a specific growth regulator. However,…”
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Protein fold analysis of the B30.2-like domain by Seto, Marian H., Liu, Hsiao-Lai C., Zajchowski, Deborah A., Whitlow, Marc

“…The B30.2‐like domain occurs in some members of a diverse and growing family of proteins containing zinc‐binding B‐box motifs, whose functions include…”
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Estrogen modulation of apolipoprotein(a) expression. Identification of a regulatory element by Boffelli, D, Zajchowski, D A, Yang, Z, Lawn, R M

“…Elevated plasma levels of the lipoprotein particle Lp(a) are a major risk factor for cardiovascular disease. Lp(a) plasma levels are determined by the level of…”
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Proteinase Inhibitor 9, an Inhibitor of Granzyme B-mediated Apoptosis, Is a Primary Estrogen-inducible Gene in Human Liver Cells by Kanamori, Hiroshi, Krieg, Sacha, Mao, Chengjian, Di Pippo, Vincent A., Wang, Stanley, Zajchowski, Deborah A., Shapiro, David J.

“…Although liver is an estrogen target tissue, the number of hepatic genes known to be directly induced by estrogen is very small. We identified proteinase…”
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Abstract POSTER-TECH-1127: Genomic profiles inform treatment decisions and enable future drug/biomarker discovery by Zajchowski, D. A., Whitlow, M., Zajchowski, K. M., Shawver, L. K.

“…Abstract Purpose: Despite major progress in the molecular characterization of ovarian cancers (OC), women with recurrent, advanced stage OC continue to be…”
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Abstract MIP-056: CONSTITUTIVELY ACTIVE ESTROGEN RECEPTOR–ALPHA LIGAND BINDING DOMAIN (ERA–LBD) MUTATIONS IN OVARIAN CARCINOMA by Elvin, J. A., Gay, L., Colon-Otero, G., Jorgensen, M., Havrilesky, L., Zajchowski, D., Shawver, L, Valea, F. A., Aithal, S, Ross, J. S., Markman, M., Gaillard, S.

“…Abstract OBJECTIVES: Mutations in ESR1 that are acquired following treatment with aromatase inhibitors commonly underlie resistance to endocrine therapy in…”
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Different estrogen receptor structural domains are required for estrogen- and tamoxifen-dependent anti-proliferative activity in human mammary epithelial cells expressing an exogenous estrogen receptor by Zajchowski, Deborah A., Webster, Lynn, Humm, Rhonda, White, Frank A., Simmons, Sandra J., Bartholdi, Marty

“…Estrogen (E) inhibits the growth of both non-tumorigenic, immortal human mammary epithelial cells (HMEC) and breast cancer cells which stably express exogenous…”
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