Search Results - "Zajac, Allan J"

Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection by Botta, Davide, Fuller, Michael J, Marquez-Lago, Tatiana T, Bachus, Holly, Bradley, John E, Weinmann, Amy S, Zajac, Allan J, Randall, Troy D, Lund, Frances E, León, Beatriz, Ballesteros-Tato, André

“…Humoral immunity is necessary for controlling viral infection. Ballesteros-Tato and colleagues show that development of follicular regulatory T cells is…”
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Vital Role for Interleukin-21 in the Control of a Chronic Viral Infection by Yi, John S, Du, Ming, Zajac, Allan J

“…Understanding the factors that regulate the induction, quality, and longevity of antiviral T cell responses is essential for devising rational strategies to…”
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Immune Exhaustion: Past Lessons and New Insights from Lymphocytic Choriomeningitis Virus by Kahan, Shannon M, Zajac, Allan J

“…Lymphocytic choriomeningitis virus (LCMV) is a paradigm-forming experimental system with a remarkable track record of contributing to the discovery of many of…”
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A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control by Xin, Gang, Schauder, David M., Lainez, Begoña, Weinstein, Jason S., Dai, Zhengxi, Chen, Yuhong, Esplugues, Enric, Wen, Renren, Wang, Demin, Parish, Ian A., Zajac, Allan J., Craft, Joe, Cui, Weiguo

“…Control of chronic viral infections by CD8 T cells is critically dependent on CD4 help. In particular, helper-derived IL-21 plays a key role in sustaining the…”
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IL-17RA is essential for optimal localization of follicular Th cells in the germinal center light zone to promote autoantibody-producing B cells by Ding, Yanna, Li, Jun, Wu, Qi, Yang, Pingar, Luo, Bao, Xie, Shutao, Druey, Kirk M, Zajac, Allan J, Hsu, Hui-Chen, Mountz, John D

“…Germinal centers (GCs) provide a microenvironment that promotes and regulates the interactions of B cells with follicular Th (TFH) cells. In this study, we…”
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Interleukin-21-Producing HIV-1-Specific CD8 T Cells Are Preferentially Seen in Elite Controllers by Williams, LaTonya D, Bansal, Anju, Sabbaj, Steffanie, Heath, Sonya L, Song, Wei, Tang, Jianming, Zajac, Allan J, Goepfert, Paul A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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ICAM-1–dependent tuning of memory CD8 T-cell responses following acute infection by Cox, Maureen A., Barnum, Scott R., Bullard, Daniel C., Zajac, Allan J.

“…CD8 T-cell responses are critical for protection against intracellular pathogens and tumors. The induction and properties of these responses are governed by a…”
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IL-21 and T Cell Differentiation: Consider the Context by Tian, Yuan, Zajac, Allan J

“…Accumulating studies demonstrate that IL-21 modulates the differentiation of various CD4 and CD8 T cell subsets and provide insights into the underlying…”
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Interleukin-21: a multifunctional regulator of immunity to infections by Yi, John S., Cox, Maureen A., Zajac, Allan J.

“…Interleukin-21 (IL-21) is a cytokine that has broad effects on both innate and adaptive immune responses. The roles of IL-21 in determining immunity to…”
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A Stay of Execution: Type I Interferons Pardon T Cells from Death by Natural Killers by Kahan, Shannon M., Zajac, Allan J.

“…In this issue of Immunity, Crouse et al., (2014) and Xu et al., (2014), show that by modulating the expression of natural killer (NK) cell receptor ligands,…”
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Exhausted CD8 T cells downregulate the IL-18 receptor and become unresponsive to inflammatory cytokines and bacterial co-infections by Ingram, Jennifer T, Yi, John S, Zajac, Allan J

“…During many chronic infections virus-specific CD8 T cells succumb to exhaustion as they lose their ability to respond to antigenic activation. Combinations of…”
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T cell exhaustion during persistent viral infections by Kahan, Shannon M, Wherry, E. John, Zajac, Allan J

“…Abstract Although robust and highly effective anti-viral T cells contribute to the clearance of many acute infections, viral persistence is associated with the…”
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T-cell exhaustion: characteristics, causes and conversion by Yi, John S, Cox, Maureen A, Zajac, Allan J

“…T-cell exhaustion is characterized by the stepwise and progressive loss of T-cell functions and can culminate in the physical deletion of the responding cells…”
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Editorial overview: Viral immunology before COVID-19 by Oxenius, Annette, Zajac, Allan J

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Anti-viral CD8 T cells and the cytokines that they love by Cox, Maureen A, Kahan, Shannon M, Zajac, Allan J

“…Abstract Viral infections cause an immunological disequilibrium that provokes CD8 T cell responses. These cells play critical roles in purging acute…”
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IL-10 Regulates Memory T Cell Development and the Balance between Th1 and Follicular Th Cell Responses during an Acute Viral Infection by Tian, Yuan, Mollo, Sarah B, Harrington, Laurie E, Zajac, Allan J

“…T cells provide protective immunity against infections by differentiating into effector cells that contribute to rapid pathogen control and by forming memory…”
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Interleukin‐21 Promotes Germinal Center Reaction by Skewing the Follicular Regulatory T Cell to Follicular Helper T Cell Balance in Autoimmune BXD2 Mice by Ding, Yanna, Li, Jun, Yang, PingAr, Luo, Bao, Wu, Qi, Zajac, Allan J., Wildner, Oliver, Hsu, Hui‐Chen, Mountz, John D.

“…Objective Follicular regulatory T (Tfr) cells act as the regulatory counterpart of follicular helper T (Tfh) cells to suppress germinal center (GC) B cell…”
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Cytokines and the inception of CD8 T cell responses by Cox, Maureen A, Harrington, Laurie E, Zajac, Allan J

“…The activation and differentiation of CD8 T cells is a necessary first step that endows these cells with the phenotypic and functional properties required for…”
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Memory CD4 T cells emerge from effector T-cell progenitors by Weaver, Casey T, Harrington, Laurie E, Oliver, James R, Zajac, Allan J, Janowski, Karen M

“…A hallmark of adaptive immunity is the generation of memory T cells that confer long-lived, antigen-specific protection against repeat challenges by pathogens…”
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A Context-Dependent Role for IL-21 in Modulating the Differentiation, Distribution, and Abundance of Effector and Memory CD8 T Cell Subsets by Tian, Yuan, Cox, Maureen A, Kahan, Shannon M, Ingram, Jennifer T, Bakshi, Rakesh K, Zajac, Allan J

“…The activation of naive CD8 T cells typically results in the formation of effector cells (TE) as well as phenotypically distinct memory cells that are retained…”
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