Search Results - "Zaiss, Dietmar M.W."

Stabilization of the Transcription Factor Foxp3 by the Deubiquitinase USP7 Increases Treg-Cell-Suppressive Capacity by van Loosdregt, Jorg, Fleskens, Veerle, Fu, Juan, Brenkman, Arjan B., Bekker, Cornelis P.J., Pals, Cornelieke E.G.M., Meerding, Jenny, Berkers, Celia R., Barbi, Joseph, Gröne, Andrea, Sijts, Alice J.A.M., Maurice, Madelon M., Kalkhoven, Eric, Prakken, Berent J., Ovaa, Huib, Pan, Fan, Zaiss, Dietmar M.W., Coffer, Paul J.

“…Stable Foxp3 expression is required for the development of functional regulatory T (Treg) cells. Here, we demonstrate that the expression of the transcription…”
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Emerging functions of amphiregulin in orchestrating immunity, inflammation, and tissue repair by Zaiss, Dietmar M W, Gause, William C, Osborne, Lisa C, Artis, David

“…Type 2 inflammatory responses can be elicited by diverse stimuli, including toxins, venoms, allergens, and infectious agents, and play critical roles in…”
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Amphiregulin Enhances Regulatory T Cell-Suppressive Function via the Epidermal Growth Factor Receptor by Zaiss, Dietmar M.W., van Loosdregt, Jorg, Gorlani, Andrea, Bekker, Cornelis P.J., Gröne, Andrea, Sibilia, Maria, van Bergen en Henegouwen, Paul M.P., Roovers, Rob C., Coffer, Paul J., Sijts, Alice J.A.M.

“…Epidermal growth factor receptor (EGFR) is known to be critically involved in tissue development and homeostasis as well as in the pathogenesis of cancer. Here…”
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Type 2 innate lymphoid cells treat and prevent acute gastrointestinal graft-versus-host disease by Bruce, Danny W, Stefanski, Heather E, Vincent, Benjamin G, Dant, Trisha A, Reisdorf, Shannon, Bommiasamy, Hemamalini, Serody, David A, Wilson, Justin E, McKinnon, Karen P, Shlomchik, Warren D, Armistead, Paul M, Ting, Jenny P Y, Woosley, John T, Blazar, Bruce R, Zaiss, Dietmar M W, McKenzie, Andrew N J, Coghill, James M, Serody, Jonathan S

“…Acute graft-versus-host disease (aGVHD) is the most common complication for patients undergoing allogeneic stem cell transplantation. Despite extremely…”
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Proteasome Immunosubunit Multicatalytic Endopeptidase Complex-Like 1 Is a T-Cell-Intrinsic Factor Influencing Homeostatic Expansion by Zaiss, Dietmar M.W, de Graaf, Natascha, Sijts, Alice J.A.M

“…Homeostatic regulatory mechanisms maintain the constant ratios between different lymphocyte subsets in the secondary lymphoid organs. How this dynamic…”
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Pre-existing virus-specific CD8+ T-cells provide protection against pneumovirus-induced disease in mice by van Helden, Mary J.G, van Kooten, Peter J.S, Bekker, Cornelis P.J, Gröne, Andrea, Topham, David J, Easton, Andrew J, Boog, Claire J.P, Busch, Dirk H, Zaiss, Dietmar M.W, Sijts, Alice J.A.M

“…Highlights ► NK cells and CD8+ T-cells expand relatively late following pneumovirus infection. ► Memory CD8+ T-cells support type 1 skewing of…”
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Enumeration of Cytotoxic CD8 T Cells Ex Vivo during the Response to Listeria monocytogenes Infection by Zaiss, Dietmar M.W, Sijts, Alice J.A.M, Mosmann, Tim R

“…Cytotoxicity is a key effector function of CD8 T cells. However, what proportion of antigen-specific CD8 T cells in vivo exert cytotoxic activity during a…”
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Tissue-specific contribution of macrophages to wound healing by Minutti, Carlos M., Knipper, Johanna A., Allen, Judith E., Zaiss, Dietmar M.W.

“…Macrophages are present in all tissues, either as resident cells or monocyte-derived cells that infiltrate into tissues. The tissue site largely determines the…”
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IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin–EGFR interactions by Monticelli, Laurel A., Osborne, Lisa C., Noti, Mario, Tran, Sara V., Zaiss, Dietmar M. W., Artis, David

“…The barrier surfaces of the skin, lung, and intestine are constantly exposed to environmental stimuli that can result in inflammation and tissue damage…”
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Introducing our new series: Clinical and Experimental Treatment of by Zaiss, Dietmar M W

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Amphiregulin as a driver of tissue fibrosis by Zaiss, Dietmar M. W.

“…Todd et al (page 825) show that the epidermal growth factor–like growth factor amphiregulin is significantly more expressed in the lungs of lung transplant…”
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Sugar addiction: An Achilles' heel of auto-immune diseases? by Zaiss, Dietmar M W, Coffer, Paul J

“…In this issue of Cell Metabolism, Hochrein et al. identify a metabolic checkpoint controlling the transcriptional programming of effector CD4 T cells. The…”
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Amphiregulin-producing γδ T cells are vital for safeguarding oral barrier immune homeostasis by Krishnan, Siddharth, Prise, Ian E., Wemyss, Kelly, Schenck, Louis P., Bridgeman, Hayley M., McClure, Flora A., Zangerle-Murray, Tamsin, O’Boyle, Conor, Barbera, Thomas A., Mahmood, Faiza, Bowdish, Dawn M. E., Zaiss, Dietmar M. W., Grainger, John R., Konkel, Joanne E.

“…γδ T cells are enriched at barrier sites such as the gut, skin, and lung, where their roles in maintaining barrier integrity are well established. However, how…”
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A second gene encoding the mouse proteasome activator PA28β subunit is part of a LINE1 element and is driven by a LINE1 promoter by Zaiss, Dietmar M.W, Kloetzel, Peter-M

“…The PMSE2 gene encodes the β-subunit of the proteasome activator PA28 and, as shown by genomic Southern blot analysis, there probably exist four copies sharing…”
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Forkhead box transcription factors as context-dependent regulators of lymphocyte homeostasis by Zaiss, Dietmar M. W., Coffer, Paul J.

“…Lymphocytes have evolved to react rapidly and robustly to changes in their local environment by using transient adaptations and by regulating their terminal…”
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Cooperation of ILC2s and TH2 cells in the expulsion of intestinal helminth parasites by Zaiss, Dietmar M. W., Pearce, Edward J., Artis, David, McKenzie, Andrew N. J., Klose, Christoph S. N.

“…Type 2 immune responses form a critical defence against enteric worm infections. In recent years, mouse models have revealed shared and unique functions for…”
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A human IgE bispecific antibody shows potent cytotoxic capacity mediated by monocytes by Vukovic, Natasa, Halabi, Samer, Russo-Cabrera, Joan Salvador, Blokhuis, Bart, Berraondo, Pedro, Redegeld, Frank A.M., Zaiss, Dietmar M.W.

“…The generation of bispecific antibodies (bsAbs) targeting two different antigens opens a new level of specificity and, compared to mAbs, improved clinical…”
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Local proliferation of monocytes by Jenkins, Stephen J., Knipper, Johanna A., Zaiss, Dietmar M. W.

“…Discussion on how monocytes may contribute to the expansion of Mϕ populations at the site of inflammation…”
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Canonical Wnt Signaling Negatively Modulates Regulatory T Cell Function by van Loosdregt, Jorg, Fleskens, Veerle, Tiemessen, Machteld M., Mokry, Michal, van Boxtel, Ruben, Meerding, Jenny, Pals, Cornelieke E.G.M., Kurek, Dorota, Baert, Miranda R.M., Delemarre, Eveline M., Gröne, Andrea, Koerkamp, Marianne J.A. Groot, Sijts, Alice J.A.M., Nieuwenhuis, Edward E.S., Maurice, Madelon M., van Es, Johan H., ten Berge, Derk, Holstege, Frank C., Staal, Frank J.T., Zaiss, Dietmar M.W., Prakken, Berent J., Coffer, Paul J.

“…Foxp3 is crucial for both the development and function of regulatory T (Treg) cells; however, the posttranslational mechanisms regulating Foxp3 transcriptional…”
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The Immune System's Contribution to the Clinical Efficacy of EGFR Antagonist Treatment by MacDonald, Felicity, Zaiss, Dietmar M W

“…Epidermal Growth Factor Receptor (EGFR) antagonists were one of the first anti-cancer treatments developed targeting a Receptor Tyrosine Kinase. However, the…”
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