Search Results - "Zaiss, Anne K"

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response by Clark, Sharon A, Pétrilli, Virginie, Muruve, Daniel A, White, Lindsay R, Parks, Robin J, Tschopp, Jurg, Zaiss, Anne K, Ross, P. Joel

“…The innate immune system recognizes nucleic acids during infection and tissue damage. Whereas viral RNA is detected by endosomal toll-like receptors (TLR3,…”
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Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-κB and NFAT transcriptional pathways by Kirkby, Nicholas S., Chan, Melissa V., Zaiss, Anne K., Garcia-Vaz, Eliana, Jiao, Jing, Berglund, Lisa M., Verdu, Elena F., Ahmetaj-Shala, Blerina, Wallace, John L., Herschman, Harvey R., Gomez, Maria F., Mitchell, Jane A.

“…Cyclooxygenase-2 (COX-2) is an inducible enzyme that drives inflammation and is the therapeutic target for widely used nonsteroidal antiinflammatory drugs…”
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The influence of innate and pre-existing immunity on adenovirus therapy by Zaiss, Anne K., Machado, Hidevaldo B., Herschman, Harvey R.

“…Recombinant adenovirus serotype 5 (Ad5) vectors have been studied extensively in preclinical gene therapy models and in a range of clinical trials. However,…”
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LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression by Kirkby, Nicholas S, Zaiss, Anne K, Urquhart, Paula, Jiao, Jing, Austin, Philip J, Al-Yamani, Malak, Lundberg, Martina H, MacKenzie, Louise S, Warner, Timothy D, Nicolaou, Anna, Herschman, Harvey R, Mitchell, Jane A

“…There are two schools of thought regarding the cyclooxygenase (COX) isoform active in the vasculature. Using urinary prostacyclin markers some groups have…”
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Complement Is an Essential Component of the Immune Response to Adeno-Associated Virus Vectors by ZAISS, Anne K, COTTER, Matthew J, WHITE, Lindsay R, CLARK, Sharon A, WONG, Norman C. W, HOLERS, V. Michael, BARTLETT, Jeffrey S, MURUVE, Daniel A

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Helper-Dependent Adenovirus Vectors Elicit Intact Innate but Attenuated Adaptive Host Immune Responses In Vivo by MURUVE, Daniel A, COTTER, Matthew J, PARKS, Robin J, ZAISS, Anne K, WHITE, Lindsay R, QIANG LIU, CHAN, Trevor, CLARK, Sharon A, ROSS, P. Joel, MEULENBROEK, Robert A, MAELANDSMO, Gunhild M

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Differential Effects of Murine and Human Factor X on Adenovirus Transduction via Cell-surface Heparan Sulfate by Zaiss, Anne K., Lawrence, Roger, Elashoff, David, Esko, Jeffrey D., Herschman, Harvey R.

“…Serum coagulation factor X (FX) is proposed to play a major role in adenovirus tropism, promoting transduction by bridging the virus to cell-surface heparan…”
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Reversible suppression of cyclooxygenase 2 (COX-2) expression in vivo by inducible RNA interference by Zaiss, Anne K, Zuber, Johannes, Chu, Chun, Machado, Hidevaldo B, Jiao, Jing, Catapang, Arthur B, Ishikawa, Tomo-o, Gil, Jose S, Lowe, Scott W, Herschman, Harvey R

“…Prostaglandin-endoperoxide synthase 2 (PTGS2), also known as cyclooxygenase 2 (COX-2), plays a critical role in many normal physiological functions and…”
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Neutrophils Interact with Adenovirus Vectors via Fc Receptors and Complement Receptor 1 by COTTER, Matthew J, ZAISS, Anne K, MURUVE, Daniel A

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The role of capsid-endothelial interactions in the innate immune response to adenovirus vectors by Liu, Qiang, Zaiss, Anne K, Colarusso, Pina, Patel, Kamala, Haljan, Gregory, Wickham, Thomas J, Muruve, Daniel A

“…Adenovirus (Ad) vectors can produce inflammatory responses at high doses. Intravenous administration of an Ad vector expressing green fluorescent protein…”
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Activation of p38 and ERK Signaling during Adenovirus Vector Cell Entry Lead to Expression of the C-X-C Chemokine IP-10 by Tibbles, Lee Anne, Spurrell, Jason C L, Bowen, Gloria P, Liu, Qiang, Lam, Mindy, Zaiss, Anne K, Robbins, Stephen M, Hollenberg, Morley D, Wickham, Thomas J, Muruve, Daniel A

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Hepatocyte Heparan Sulfate Is Required for Adeno-Associated Virus 2 but Dispensable for Adenovirus 5 Liver Transduction In Vivo by Zaiss, Anne K, Foley, Erin M, Lawrence, Roger, Schneider, Lina S, Hoveida, Hamidreza, Secrest, Patrick, Catapang, Arthur B, Yamaguchi, Yu, Alemany, Ramon, Shayakhmetov, Dmitry M, Esko, Jeffrey D, Herschman, Harvey R

“…Adeno-associated virus 2 (AAV2) and adenovirus 5 (Ad5) are promising gene therapy vectors. Both display liver tropism and are currently thought to enter…”
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Differential COX-2 induction by viral and bacterial PAMPs: Consequences for cytokine and interferon responses and implications for anti-viral COX-2 directed therapies by Kirkby, Nicholas S., Zaiss, Anne K., Wright, William R., Jiao, Jing, Chan, Melissa V., Warner, Timothy D., R. Herschman, Harvey, Mitchell, Jane A.

“…•We report interactions of Toll-like receptors (TLRs) with COX enzymes in vivo.•COX-2 was broadly induced by LPS (TLR4) but more locally by poly(I:C)…”
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Reduced T-dependent humoral immunity in CD20-deficient mice by Morsy, Deyaa El Deen, Sanyal, Ratna, Zaiss, Anne K, Deo, Rucha, Muruve, Dan A, Deans, Julie P

“…CD20 is a tetraspanning membrane protein expressed on B lymphocytes. CD20 deficiency in both mice and humans has recently been shown to have deleterious…”
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Platelets Contain Tissue Factor Pathway Inhibitor-2 Derived from Megakaryocytes and Inhibits Fibrinolysis by Vadivel, Kanagasabai, Ponnuraj, Sathya-Moorthy, Kumar, Yogesh, Zaiss, Anne K., Bunce, Matthew W., Camire, Rodney M., Wu, Ling, Evseenko, Denis, Herschman, Harvey R., Bajaj, Madhu S., Bajaj, S. Paul

“…Tissue factor pathway inhibitor-2 (TFPI-2) is a homologue of TFPI-1 and contains three Kunitz-type domains and a basic C terminus region. The N-terminal domain…”
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Immune responses to adeno-associated virus vectors by Zaiss, Anne K, Muruve, Daniel A

“…One of the biggest challenges in optimizing viral vectors for gene therapy relates to the immune response of the host. Adeno-associated virus (AAV) vectors are…”
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Antiviral Antibodies Target Adenovirus to Phagolysosomes and Amplify the Innate Immune Response by Zaiss, Anne K, Vilaysane, Akosua, Cotter, Matthew J, Clark, Sharon A, Meijndert, H. Christopher, Colarusso, Pina, Yates, Robin M, Petrilli, Virginie, Tschopp, Jurg, Muruve, Daniel A

“…Adenovirus is a nonenveloped dsDNA virus that activates intracellular innate immune pathways. In vivo, adenovirus-immunized mice displayed an enhanced innate…”
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Enhanced Antifibrinolytic Efficacy of a Plasmin-Specific Kunitz-Inhibitor (60-Residue Y11T/L17R with C-Terminal IEK) of Human Tissue Factor Pathway Inhibitor Type-2 Domain1 by Vadivel, Kanagasabai, Zaiss, Anne K, Kumar, Yogesh, Fabian, Frank M, Ismail, Ayman E A, Arbing, Mark A, Buchholz, Wallace G, Velander, William H, Bajaj, S Paul

“…Current antifibrinolytic agents reduce blood loss by inhibiting plasmin active sites (e.g., aprotinin) or by preventing plasminogen/tissue plasminogen…”
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Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-[kappa]B and NFAT transcriptional pathways by Kirkby, Nicholas S, Chan, Melissa V, Zaiss, Anne K, Garcia-Vaz, Eliana, Jiao, Jing, Berglund, Lisa M, Verdu, Elena F, Ahmetaj-Shala, Blerina, Wallace, John L, Herschman, Harvey R, Gomez, Maria F, Mitchell, Jane A

“…Cyclooxygenase-2 (COX-2) is an inducible enzyme that drives inflammation and is the therapeutic target for widely used nonsteroidal antiinflammatory drugs…”
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Reversible Suppression of Cyclooxygenase 2 by Zaiss, Anne K, Zuber, Johannes, Chu, Chun, Machado, Hidevaldo B, Jiao, Jing, Catapang, Arthur B, Ishikawa, Tomo-o, Gil, Jose S, Lowe, Scott W, Herschman, Harvey R

“…Prostaglandin-endoperoxide synthase 2 (PTGS2), also known as cyclooxygenase 2 (COX-2), plays a critical role in many normal physiological functions and…”
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