Search Results - "Zaidi, Mone"

Endothelial cells revealed as chondroclasts by Iqbal, Jameel, Zaidi, Mone

“…Osteoclasts are known for their role in bone resorption. A study now shows that a vascular–associated osteoclast subtype at the growth plate also regulates…”
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The myokine irisin increases cortical bone mass by Colaianni, Graziana, Cuscito, Concetta, Mongelli, Teresa, Pignataro, Paolo, Buccoliero, Cinzia, Liu, Peng, Lu, Ping, Sartini, Loris, Di Comite, Mariasevera, Mori, Giorgio, Di Benedetto, Adriana, Brunetti, Giacomina, Yuen, Tony, Sun, Li, Reseland, Janne E., Colucci, Silvia, New, Maria I., Zaidi, Mone, Cinti, Saverio, Grano, Maria

“…It is unclear how physical activity stimulates new bone synthesis. We explored whether irisin, a newly discovered myokine released upon physical activity,…”
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Peer review without gatekeeping by Eisen, Michael B, Akhmanova, Anna, Behrens, Timothy E, Diedrichsen, Jörn, Harper, Diane M, Iordanova, Mihaela D, Weigel, Detlef, Zaidi, Mone

“…eLife is changing its editorial process to emphasize public reviews and assessments of preprints by eliminating accept/reject decisions after peer review…”
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Genotype–phenotype correlation in 1,507 families with congenital adrenal hyperplasia owing to 21-hydroxylase deficiency by New, Maria I., Abraham, Moolamannil, Gonzalez, Brian, Dumic, Miroslav, Razzaghy-Azar, Maryam, Chitayat, David, Sun, Li, Zaidi, Mone, Wilson, Robert C., Yuen, Tony

“…Over the last two decades, we have extensively studied the genetics of congenital adrenal hyperplasia caused by 21-hydroxylase deficiency (CAH) and have…”
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Blocking FSH induces thermogenic adipose tissue and reduces body fat by Liu, Peng, Ji, Yaoting, Yuen, Tony, Rendina-Ruedy, Elizabeth, DeMambro, Victoria E., Dhawan, Samarth, Abu-Amer, Wahid, Izadmehr, Sudeh, Zhou, Bin, Shin, Andrew C., Latif, Rauf, Thangeswaran, Priyanthan, Gupta, Animesh, Li, Jianhua, Shnayder, Valeria, Robinson, Samuel T., Yu, Yue Eric, Zhang, Xingjian, Yang, Feiran, Lu, Ping, Zhou, Yu, Zhu, Ling-Ling, Oberlin, Douglas J., Davies, Terry F., Reagan, Michaela R., Brown, Aaron, Kumar, T. Rajendra, Epstein, Solomon, Iqbal, Jameel, Avadhani, Narayan G., New, Maria I., Molina, Henrik, van Klinken, Jan B., Guo, Edward X., Buettner, Christoph, Haider, Shozeb, Bian, Zhuan, Sun, Li, Rosen, Clifford J., Zaidi, Mone

“…Menopause is associated with bone loss and enhanced visceral adiposity. A polyclonal antibody that targets the β-subunit of the pituitary hormone…”
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A global view of the aspiring physician-scientist by Williams, Christopher S, Rathmell, W Kimryn, Carethers, John M, Harper, Diane M, Lo, YM Dennis, Ratcliffe, Peter J, Zaidi, Mone

“…Physician-scientists have epitomized the blending of deep, rigorous impactful curiosity with broad attention to human health for centuries. While we aspire to…”
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From the gut to the strut: where inflammation reigns, bone abstains by Iqbal, Jameel, Yuen, Tony, Sun, Li, Zaidi, Mone

“…In this issue of the JCI, Li et al. show that germ-free mice, when chemically castrated, do not lose bone - a finding that unequivocally establishes a role of…”
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Bone circuitry and interorgan skeletal crosstalk by Zaidi, Mone, Kim, Se-Min, Mathew, Mehr, Korkmaz, Funda, Sultana, Farhath, Miyashita, Sari, Gumerova, Anisa Azatovna, Frolinger, Tal, Moldavski, Ofer, Barak, Orly, Pallapati, Anusha, Rojekar, Satish, Caminis, John, Ginzburg, Yelena, Ryu, Vitaly, Davies, Terry F, Lizneva, Daria, Rosen, Clifford J, Yuen, Tony

“…The past decade has seen significant advances in our understanding of skeletal homeostasis and the mechanisms that mediate the loss of bone integrity in…”
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Noninvasive Prenatal Diagnosis of Congenital Adrenal Hyperplasia Using Cell-Free Fetal DNA in Maternal Plasma by New, Maria I, Tong, Yu K, Yuen, Tony, Jiang, Peiyong, Pina, Christian, Chan, K. C. Allen, Khattab, Ahmed, Liao, Gary J. W, Yau, Mabel, Kim, Se-Min, Chiu, Rossa W. K, Sun, Li, Zaidi, Mone, Lo, Y. M

“…Context: Congenital adrenal hyperplasia (CAH) is an autosomal recessive condition that arises from mutations in CYP21A2 gene, which encodes for the…”
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An atlas of brain-bone sympathetic neural circuits in mice by Ryu, Vitaly, Gumerova, Anisa Azatovna, Witztum, Ronit, Korkmaz, Funda, Cullen, Liam, Kannangara, Hasni, Moldavski, Ofer, Barak, Orly, Lizneva, Daria, Goosens, Ki A, Stanley, Sarah, Kim, Se-Min, Yuen, Tony, Zaidi, Mone

“…There is clear evidence that the sympathetic nervous system (SNS) mediates bone metabolism. Histological studies show abundant SNS innervation of the…”
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Minireview: The Link Between Fat and Bone: Does Mass Beget Mass? by Zaidi, Mone, Buettner, Christoph, Sun, Li, Iqbal, Jameel

“…Osteoporosis is less common in individuals with high fat mass. This putative osteoprotection is likely an adaptive mechanism that allows obese individuals to…”
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FSH and ApoE4 contribute to Alzheimer’s disease-like pathogenesis via C/EBPβ/δ-secretase in female mice by Xiong, Jing, Kang, Seong Su, Wang, Mengmeng, Wang, Zhihao, Xia, Yiyuan, Liao, Jianming, Liu, Xia, Yu, Shan-Ping, Zhang, Zhaohui, Ryu, Vitaly, Yuen, Tony, Zaidi, Mone, Ye, Keqiang

“…Alzheimer’s disease (AD) is the most common dementia. It is known that women with one ApoE4 allele display greater risk and earlier onset of AD compared with…”
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Implementing a "publish, then review" model of publishing by Eisen, Michael B, Akhmanova, Anna, Behrens, Timothy E, Harper, Diane M, Weigel, Detlef, Zaidi, Mone

“…From July 2021 eLife will only review manuscripts already published as preprints, and will focus its editorial process on producing public reviews to be posted…”
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Development and biophysical characterization of a humanized FSH-blocking monoclonal antibody therapeutic formulated at an ultra-high concentration by Rojekar, Satish, Pallapati, Anusha R, Gimenez-Roig, Judit, Korkmaz, Funda, Sultana, Farhath, Sant, Damini, Haeck, Clement M, Macdonald, Anne, Kim, Se-Min, Rosen, Clifford J, Barak, Orly, Meseck, Marcia, Caminis, John, Lizneva, Daria, Yuen, Tony, Zaidi, Mone

“…Highly concentrated antibody formulations are oftentimes required for subcutaneous, self-administered biologics. Here, we report the development of a unique…”
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The hepcidin regulator erythroferrone is a new member of the erythropoiesis-iron-bone circuitry by Castro-Mollo, Melanie, Gera, Sakshi, Ruiz-Martinez, Marc, Feola, Maria, Gumerova, Anisa, Planoutene, Marina, Clementelli, Cara, Sangkhae, Veena, Casu, Carla, Kim, Se-Min, Ostland, Vaughn, Han, Huiling, Nemeth, Elizabeta, Fleming, Robert, Rivella, Stefano, Lizneva, Daria, Yuen, Tony, Zaidi, Mone, Ginzburg, Yelena

“…Erythroblast erythroferrone (ERFE) secretion inhibits hepcidin expression by sequestering several bone morphogenetic protein (BMP) family members to increase…”
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The high-density lipoprotein receptor Scarb1 is required for normal bone differentiation in vivo and in vitro by Tourkova, Irina L., Dobrowolski, Steven F., Secunda, Cassandra, Zaidi, Mone, Papadimitriou-Olivgeri, Ioanna, Papachristou, Dionysios J., Blair, Harry C.

“…We examined bone formation and turnover in high-density lipoprotein (HDL) receptor, scavenger receptor type I (Scarb1), knockout animals relative to wild-type…”
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MAF1, a repressor of RNA polymerase III-dependent transcription, regulates bone mass by Phillips, Ellen, Ahmad, Naseer, Sun, Li, Iben, James, Walkey, Christopher J, Rusin, Aleksandra, Yuen, Tony, Rosen, Clifford J, Willis, Ian M, Zaidi, Mone, Johnson, Deborah L

“…MAF1, a key repressor of RNA polymerase (pol) III-mediated transcription, has been shown to promote mesoderm formation in vitro. Here, we show that MAF1 plays…”
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Regulation of bone remodeling by vasopressin explains the bone loss in hyponatremia by Tamma, Roberto, Li Sun, Cuscito, Concetta, Lu, Ping, Corcelli, Michelangelo, Li, Jianhua, Colaianni, Graziana, Moonga, Surinder S., Di Benedetto, Adriana, Grano, Maria, Colucci, Silvia, Yuen, Tony, New, Maria I., Zallone, Alberta, Zaidi, Mone

“…Although hyponatremia is known to be associated with osteoporosis and a high fracture risk, the mechanism through which bone loss ensues has remained unclear…”
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Structural insights into the career path between pre- and postgraduate physician-scientist training programs by Williams, Christopher S, Gallagher, Emily J, Rockey, Don C, Ajijola, Olujimi A, Hu, Patrick J, Kazmierczak, Barbara I, Kontos, Christopher D, Vyas, Jatin M, Zaidi, Mone, Rhee, Kyu Y

“…The growing complexities of clinical medicine and biomedical research have clouded the career path for physician-scientists. In this perspective piece, we…”
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Actions of pituitary hormones beyond traditional targets by Zaidi, Mone, New, Maria I, Blair, Harry C, Zallone, Alberta, Baliram, Ramkumarie, Davies, Terry F, Cardozo, Christopher, Iqbal, James, Sun, Li, Rosen, Clifford J, Yuen, Tony

“…Studies over the past decade have challenged the long-held belief that pituitary hormones have singular functions in regulating specific target tissues,…”
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