Search Results - "Zahn, Roland C"

Ad26 vector-based COVID-19 vaccine encoding a prefusion-stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses by Bos, Rinke, Rutten, Lucy, van der Lubbe, Joan E. M., Bakkers, Mark J. G., Hardenberg, Gijs, Wegmann, Frank, Zuijdgeest, David, de Wilde, Adriaan H., Koornneef, Annemart, Verwilligen, Annemiek, van Manen, Danielle, Kwaks, Ted, Vogels, Ronald, Dalebout, Tim J., Myeni, Sebenzile K., Kikkert, Marjolein, Snijder, Eric J., Li, Zhenfeng, Barouch, Dan H., Vellinga, Jort, Langedijk, Johannes P. M., Zahn, Roland C., Custers, Jerome, Schuitemaker, Hanneke

“…Development of effective preventative interventions against SARS-CoV-2, the etiologic agent of COVID-19 is urgently needed. The viral surface spike (S) protein…”
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A Double-Blind, Randomized, Placebo-Controlled Phase 1 Study of Ad26.ZIKV.001, an Ad26-Vectored Anti-Zika Virus Vaccine by Salisch, Nadine C, Stephenson, Kathryn E, Williams, Kristi, Cox, Freek, van der Fits, Leslie, Heerwegh, Dirk, Truyers, Carla, Habets, Marrit N, Kanjilal, Diane G, Larocca, Rafael A, Abbink, Peter, Liu, Jinyan, Peter, Lauren, Fierro, Carlos, De La Barrera, Rafael A, Modjarrad, Kayvon, Zahn, Roland C, Hendriks, Jenny, Cahill, Conor P, Leyssen, Maarten, Douoguih, Macaya, van Hoof, Johan, Schuitemaker, Hanneke, Barouch, Dan H

“…Zika virus (ZIKV) may cause severe congenital disease after maternal-fetal transmission. No vaccine is currently available. To assess the safety and…”
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CoPoP liposomes displaying stabilized clade C HIV-1 Env elicit tier 2 multiclade neutralization in rabbits by Koornneef, Annemart, Vanshylla, Kanika, Hardenberg, Gijs, Rutten, Lucy, Strokappe, Nika M., Tolboom, Jeroen, Vreugdenhil, Jessica, Boer, Karin Feddes-de, Perkasa, Aditya, Blokland, Sven, Burger, Judith A., Huang, Wei-Chiao, Lovell, Jonathan F., van Manen, Danielle, Sanders, Rogier W., Zahn, Roland C., Schuitemaker, Hanneke, Langedijk, Johannes P. M., Wegmann, Frank

“…One of the strategies towards an effective HIV-1 vaccine is to elicit broadly neutralizing antibody responses that target the high HIV-1 Env diversity. Here,…”
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Booster with Ad26.COV2.S or Omicron-adapted vaccine enhanced immunity and efficacy against SARS-CoV-2 Omicron in macaques by Solforosi, Laura, Costes, Lea M. M., Tolboom, Jeroen T. B. M., McMahan, Katherine, Anioke, Tochi, Hope, David, Murdza, Tetyana, Sciacca, Michaela, Bouffard, Emily, Barrett, Julia, Wu, Cindy, Hachmann, Nicole, Miller, Jessica, Yu, Jingyou, He, Xuan, Jacob-Dolan, Catherine, Huber, Sietske K. Rosendahl, Dekking, Liesbeth, Chamanza, Ronnie, Choi, Ying, Boer, Karin Feddes-de, Barouch, Dan H., Schuitemaker, Hanneke, Zahn, Roland C., Wegmann, Frank

“…Omicron spike (S) encoding vaccines as boosters, are a potential strategy to improve COVID-19 vaccine efficacy against Omicron. Here, macaques (mostly females)…”
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Restrained expansion of the recall germinal center response as biomarker of protection for influenza vaccination in mice by Kil, Laurens P, Vaneman, Joost, van der Lubbe, Joan E M, Czapska-Casey, Dominika, Tolboom, Jeroen T B M, Roozendaal, Ramon, Zahn, Roland C, Kuipers, Harmjan, Solforosi, Laura

“…Correlates of protection (CoP) are invaluable for iterative vaccine design studies, especially in pursuit of complex vaccines such as a universal influenza…”
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Mosaic HIV-1 vaccine and SHIV challenge strain V2 loop sequence identity and protection in primates by Vanshylla, Kanika, Tolboom, Jeroen, Stephenson, Kathryn E., Feddes-de Boer, Karin, Verwilligen, Annemiek, Rosendahl Huber, Sietske Karla, Rutten, Lucy, Schuitemaker, Hanneke, Zahn, Roland C., Barouch, Dan H., Wegmann, Frank

“…The failure of human vaccine efficacy trials assessing a mosaic HIV-1 vaccine calls into question the translatability of preclinical SHIV challenge studies…”
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Mini-HA Is Superior to Full Length Hemagglutinin Immunization in Inducing Stem-Specific Antibodies and Protection Against Group 1 Influenza Virus Challenges in Mice by van der Lubbe, Joan E M, Verspuij, Johan W A, Huizingh, Jeroen, Schmit-Tillemans, Sonja P R, Tolboom, Jeroen T B M, Dekking, Liesbeth E H A, Kwaks, Ted, Brandenburg, Börries, Meijberg, Wim, Zahn, Roland C, Roozendaal, Ramon, Kuipers, Harmjan

“…Seasonal influenza vaccines are updated almost annually to match the antigenic drift in influenza hemagglutinin (HA) surface glycoprotein. A new HA stem-based…”
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A Rationally Engineered Anti-HIV Peptide Fusion Inhibitor with Greatly Reduced Immunogenicity by BRAUER, Frances, SCHMIDT, Kerstin, ZAHN, Roland C, RICHTER, Cornelia, RADEKE, Heinfried H, SCHMITZ, Jorn E, VON LAER, Dorothee, EGERER, Lisa

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Sequential use of Ad26-based vaccine regimens in NHP to induce immunity against different disease targets by Khan, Selina, Salisch, Nadine C., Gil, Ana Izquierdo, Boedhoe, Satish, Boer, Karin Feddes-de, Serroyen, Jan, Schuitemaker, Hanneke, Zahn, Roland C.

“…The adenovirus (Ad)26 serotype–based vector vaccine Ad26.COV2.S has been used in millions of subjects for the prevention of COVID-19, but potentially elicits…”
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The Biodistribution of the Spike Protein after Ad26.COV2.S Vaccination Is Unlikely to Play a Role in Vaccine-Induced Immune Thrombotic Thrombocytopenia by Marquez-Martinez, Sonia, Khan, Selina, Lubbe, Joan van der, Solforosi, Laura, Costes, Lea M M, Choi, Ying, Boedhoe, Satish, Verslegers, Mieke, Heerden, Marjolein van, Roosen, Wendy, Jonghe, Sandra De, Kristyanto, Hendy, Rezelj, Veronica, Hendriks, Jenny, Serroyen, Jan, Tolboom, Jeroen, Wegmann, Frank, Zahn, Roland C

“…Ad26.COV2.S vaccination can lead to vaccine-induced immune thrombotic thrombocytopenia (VITT), a rare but severe adverse effect, characterized by…”
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Intravenous Administration of Ad26.COV2.S Does Not Induce Thrombocytopenia or Thrombotic Events or Affect SARS-CoV-2 Spike Protein Bioavailability in Blood Compared with Intramuscular Vaccination in Rabbits by Khan, Selina, Marquez-Martinez, Sonia, Erkens, Tim, de Wilde, Adriaan, Costes, Lea M M, Vinken, Petra, De Jonghe, Sandra, Roosen, Wendy, Talia, Chiara, Chamanza, Ronnie, Serroyen, Jan, Tolboom, Jeroen, Zahn, Roland C, Wegmann, Frank

“…Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a very rare but serious adverse reaction that can occur after Ad26.COV2.S vaccination in humans,…”
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Combination Ad26.RSV.preF/preF protein vaccine induces superior protective immunity compared with individual vaccine components in preclinical models by Saeland, Eirikur, van der Fits, Leslie, Bolder, Renske, Heemskerk-van der Meer, Marjolein, Drijver, Joke, van Polanen, Yolinda, Vaneman, Cornelis, Tettero, Lisanne, Cox, Freek, Serroyen, Jan, Jorgensen, Matthew J., Langedijk, Johannes P. M., Schuitemaker, Hanneke, Callendret, Benoit, Zahn, Roland C.

“…Respiratory syncytial virus (RSV) is a leading cause of severe respiratory disease for which no licensed vaccine is available. We have previously shown that a…”
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Durability and expansion of neutralizing antibody breadth following Ad26.COV2.S vaccination of mice by Mahrokhian, Shant H., Tostanoski, Lisa H., Jacob-Dolan, Catherine, Zahn, Roland C., Wegmann, Frank, McMahan, Katherine, Yu, Jingyou, Gebre, Makda S., Bondzie, Esther A., Wan, Huahua, Powers, Olivia, Ye, Tianyi, Barrett, Julia, Schuitemaker, Hanneke, Barouch, Dan H.

“…Emerging SARS-CoV-2 variants with the potential to escape binding and neutralizing antibody responses pose a threat to vaccine efficacy. We recently reported…”
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A-to-G Hypermutation in the Genome of Lymphocytic Choriomeningitis Virus by ZAHN, Roland C, SCHELP, Ina, UTERMÖHLEN, Olaf, VON LAER, Dorothee

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High Cell-Free Virus Load and Robust Autologous Humoral Immune Responses in Breast Milk of Simian Immunodeficiency Virus-Infected African Green Monkeys by WILKS, Andrew B, PERRY, James R, EHLINGER, Elizabeth P, ZAHN, Roland C, WHITE, Robert, GAUDUIN, Marie-Claire, CARVILLE, Angela, SEAMAN, Michael S, SCHMITZ, Joern E, PERMAR, Sallie R

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Memory CD4+ T Lymphocytes in the Gastrointestinal Tract Are a Major Source of Cell-Associated Simian Immunodeficiency Virus in Chronic Nonpathogenic Infection of African Green Monkeys by SCHMITZ, Joern E, MA, Zhong-Min, HAGAN, Emily A, WILKS, Andrew B, FURR, Kathryn L, LINDE, Caitlyn H, ZAHN, Roland C, BRENCHLEY, Jason M, MILLER, Christopher J, PERMAR, Sallie R

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Inhibition of adaptive immune responses leads to a fatal clinical outcome in SIV-infected pigtailed macaques but not vervet African green monkeys by Schmitz, Jörn E, Zahn, Roland C, Brown, Charles R, Rett, Melisa D, Li, Ming, Tang, Haili, Pryputniewicz, Sarah, Byrum, Russell A, Kaur, Amitinder, Montefiori, David C, Allan, Jonathan S, Goldstein, Simoy, Hirsch, Vanessa M

“…African green monkeys (AGM) and other natural hosts for simian immunodeficiency virus (SIV) do not develop an AIDS-like disease following SIV infection. To…”
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Simian Immunodeficiency Virus (SIV)-Specific CD8+ T-Cell Responses in Vervet African Green Monkeys Chronically Infected with SIVagm by Zahn, Roland C, Rett, Melisa D, Korioth-Schmitz, Birgit, Sun, Yue, Buzby, Adam P, Goldstein, Simoy, Brown, Charles R, Byrum, Russell A, Freeman, Gordon J, Letvin, Norman L, Hirsch, Vanessa M, Schmitz, Jörn E

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Mucosal boosting enhances vaccine protection against SARS-CoV-2 in macaques by McMahan, Katherine, Wegmann, Frank, Aid, Malika, Sciacca, Michaela, Liu, Jinyan, Hachmann, Nicole P., Miller, Jessica, Jacob-Dolan, Catherine, Powers, Olivia, Hope, David, Wu, Cindy, Pereira, Juliana, Murdza, Tetyana, Mazurek, Camille R., Hoyt, Amelia, Boon, Adrianus C. M., Davis-Gardner, Meredith, Suthar, Mehul S., Martinot, Amanda J., Boursiquot, Mona, Cook, Anthony, Pessaint, Laurent, Lewis, Mark G., Andersen, Hanne, Tolboom, Jeroen, Serroyen, Jan, Solforosi, Laura, Costes, Lea M. M., Zahn, Roland C., Barouch, Dan H.

“…A limitation of current SARS-CoV-2 vaccines is that they provide minimal protection against infection with current Omicron subvariants 1 , 2 , although they…”
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Immunogenicity and efficacy of one and two doses of Ad26.COV2.S COVID vaccine in adult and aged NHP by Solforosi, Laura, Kuipers, Harmjan, Jongeneelen, Mandy, Rosendahl Huber, Sietske K, van der Lubbe, Joan E M, Dekking, Liesbeth, Czapska-Casey, Dominika N, Izquierdo Gil, Ana, Baert, Miranda R M, Drijver, Joke, Vaneman, Joost, van Huizen, Ella, Choi, Ying, Vreugdenhil, Jessica, Kroos, Sanne, de Wilde, Adriaan H, Kourkouta, Eleni, Custers, Jerome, van der Vlugt, Remko, Veldman, Daniel, Huizingh, Jeroen, Kaszas, Krisztian, Dalebout, Tim J, Myeni, Sebenzile K, Kikkert, Marjolein, Snijder, Eric J, Barouch, Dan H, Böszörményi, Kinga P, Stammes, Marieke A, Kondova, Ivanela, Verschoor, Ernst J, Verstrepen, Babs E, Koopman, Gerrit, Mooij, Petra, Bogers, Willy M J M, van Heerden, Marjolein, Muchene, Leacky, Tolboom, Jeroen T B M, Roozendaal, Ramon, Brandenburg, Boerries, Schuitemaker, Hanneke, Wegmann, Frank, Zahn, Roland C

“…Safe and effective coronavirus disease-19 (COVID-19) vaccines are urgently needed to control the ongoing pandemic. While single-dose vaccine regimens would…”
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