Search Results - "Zahedi, René P."

The Protein Import Machinery of Mitochondria—A Regulatory Hub in Metabolism, Stress, and Disease by Harbauer, Angelika B., Zahedi, René P., Sickmann, Albert, Pfanner, Nikolaus, Meisinger, Chris

“…Mitochondria fulfill central functions in bioenergetics, metabolism, and apoptosis. They import more than 1,000 different proteins from the cytosol. It had…”
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Current strategies and findings in clinically relevant post-translational modification-specific proteomics by Pagel, Oliver, Loroch, Stefan, Sickmann, Albert, Zahedi, René P

“…Mass spectrometry-based proteomics has considerably extended our knowledge about the occurrence and dynamics of protein post-translational modifications…”
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Landscape of submitochondrial protein distribution by Vögtle, F.-Nora, Burkhart, Julia M., Gonczarowska-Jorge, Humberto, Kücükköse, Cansu, Taskin, Asli Aras, Kopczynski, Dominik, Ahrends, Robert, Mossmann, Dirk, Sickmann, Albert, Zahedi, René P., Meisinger, Chris

“…The mitochondrial proteome comprises ~1000 (yeast)–1500 (human) different proteins, which are distributed into four different subcompartments. The…”
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Global Analysis of the Mitochondrial N-Proteome Identifies a Processing Peptidase Critical for Protein Stability by Vögtle, F.-Nora, Wortelkamp, Stefanie, Zahedi, René P., Becker, Dorothea, Leidhold, Claudia, Gevaert, Kris, Kellermann, Josef, Voos, Wolfgang, Sickmann, Albert, Pfanner, Nikolaus, Meisinger, Chris

“…Many mitochondrial proteins are synthesized with N-terminal presequences that are removed by specific peptidases. The N-termini of the mature proteins and thus…”
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Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition by Beck, Florian, Geiger, Jörg, Gambaryan, Stepan, Solari, Fiorella A., Dell'Aica, Margherita, Loroch, Stefan, Mattheij, Nadine J., Mindukshev, Igor, Pötz, Oliver, Jurk, Kerstin, Burkhart, Julia M., Fufezan, Christian, Heemskerk, Johan W.M., Walter, Ulrich, Zahedi, René P., Sickmann, Albert

“…Adenosine diphosphate (ADP) enhances platelet activation by virtually any other stimulant to complete aggregation. It binds specifically to the…”
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Regulation of Mitochondrial Protein Import by Cytosolic Kinases by Schmidt, Oliver, Harbauer, Angelika B., Rao, Sanjana, Eyrich, Beate, Zahedi, René P., Stojanovski, Diana, Schönfisch, Birgit, Guiard, Bernard, Sickmann, Albert, Pfanner, Nikolaus, Meisinger, Chris

“…Mitochondria import a large number of nuclear-encoded proteins via membrane-bound transport machineries; however, little is known about regulation of the…”
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Dual Function of Sdh3 in the Respiratory Chain and TIM22 Protein Translocase of the Mitochondrial Inner Membrane by Gebert, Natalia, Gebert, Michael, Oeljeklaus, Silke, von der Malsburg, Karina, Stroud, David A., Kulawiak, Bogusz, Wirth, Christophe, Zahedi, René P., Dolezal, Pavel, Wiese, Sebastian, Simon, Oliver, Schulze-Specking, Agnes, Truscott, Kaye N., Sickmann, Albert, Rehling, Peter, Guiard, Bernard, Hunte, Carola, Warscheid, Bettina, van der Laan, Martin, Pfanner, Nikolaus, Wiedemann, Nils

“…The mitochondrial inner membrane harbors the complexes of the respiratory chain and translocase complexes for precursor proteins. We have identified a further…”
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Impact of Digestion Conditions on Phosphoproteomics by Dickhut, Clarissa, Feldmann, Ingo, Lambert, Jörg, Zahedi, René P

“…In the past few years, the focus of phosphoproteomics has shifted from merely qualitative to quantitative and targeted studies. Tryptic digestion is a critical…”
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Enrichment of Cross-Linked Peptides Using Charge-Based Fractional Diagonal Chromatography (ChaFRADIC) by Tinnefeld, Verena, Venne, A. Saskia, Sickmann, Albert, Zahedi, René P

“…Chemical cross-linking of proteins is an emerging field with huge potential for the structural investigation of proteins and protein complexes. Owing to the…”
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Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach by Engel, Julian, Richters, André, Getlik, Matthäus, Tomassi, Stefano, Keul, Marina, Termathe, Martin, Lategahn, Jonas, Becker, Christian, Mayer-Wrangowski, Svenja, Grütter, Christian, Uhlenbrock, Niklas, Krüll, Jasmin, Schaumann, Niklas, Eppmann, Simone, Kibies, Patrick, Hoffgaard, Franziska, Heil, Jochen, Menninger, Sascha, Ortiz-Cuaran, Sandra, Heuckmann, Johannes M., Tinnefeld, Verena, Zahedi, René P., Sos, Martin L., Schultz-Fademrecht, Carsten, Thomas, Roman K., Kast, Stefan M., Rauh, Daniel

“…Receptor tyrosine kinases represent one of the prime targets in cancer therapy, as the dysregulation of these elementary transducers of extracellular signals,…”
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Quantifying Missing (Phospho)Proteome Regions with the Broad-Specificity Protease Subtilisin by Gonczarowska-Jorge, Humberto, Loroch, Stefan, Dell’Aica, Margherita, Sickmann, Albert, Roos, Andreas, Zahedi, René P

“…Despite huge efforts to map the human proteome using mass spectrometry the overall sequence coverage achieved to date is still below 50%. Reasons for missing…”
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A Unique Morphological Phenotype in Chemoresistant Triple-Negative Breast Cancer Reveals Metabolic Reprogramming and PLIN4 Expression as a Molecular Vulnerability by Sirois, Isabelle, Aguilar-Mahecha, Adriana, Lafleur, Josiane, Fowler, Emma, Vu, Viet, Scriver, Michelle, Buchanan, Marguerite, Chabot, Catherine, Ramanathan, Aparna, Balachandran, Banujan, Légaré, Stéphanie, Przybytkowski, Ewa, Lan, Cathy, Krzemien, Urszula, Cavallone, Luca, Aleynikova, Olga, Ferrario, Cristiano, Guilbert, Marie-Christine, Benlimame, Naciba, Saad, Amine, Alaoui-Jamali, Moulay, Saragovi, Horace Uri, Josephy, Sylvia, O'Flanagan, Ciara, Hursting, Stephen D, Richard, Vincent R, Zahedi, René P, Borchers, Christoph H, Bareke, Eric, Nabavi, Sheida, Tonellato, Peter, Roy, Josée-Anne, Robidoux, André, Marcus, Elizabeth A, Mihalcioiu, Catalin, Majewski, Jacek, Basik, Mark

“…The major obstacle in successfully treating triple-negative breast cancer (TNBC) is resistance to cytotoxic chemotherapy, the mainstay of treatment in this…”
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Simple, scalable, and ultrasensitive tip-based identification of protease substrates by Shema, Gerta, Nguyen, Minh T.N., Solari, Fiorella A., Loroch, Stefan, Venne, A. Saskia, Kollipara, Laxmikanth, Sickmann, Albert, Verhelst, Steven H.L., Zahedi, René P.

“…Proteases are in the center of many diseases, and consequently, proteases and their substrates are important drug targets as represented by an estimated 5–10%…”
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TRPM7 Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice by Gotru, Sanjeev K, Chen, Wenchun, Kraft, Peter, Becker, Isabelle C, Wolf, Karen, Stritt, Simon, Zierler, Susanna, Hermanns, Heike M, Rao, Deviyani, Perraud, Anne-Laure, Schmitz, Carsten, Zahedi, René P, Noy, Peter J, Tomlinson, Michael G, Dandekar, Thomas, Matsushita, Masayuki, Chubanov, Vladimir, Gudermann, Thomas, Stoll, Guido, Nieswandt, Bernhard, Braun, Attila

“…OBJECTIVE—TRPM7 (transient receptor potential cation channel, subfamily M, member 7) is a ubiquitously expressed bifunctional protein comprising a transient…”
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The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier by Schell, Christoph, Rogg, Manuel, Suhm, Martina, Helmstädter, Martin, Sellung, Dominik, Yasuda-Yamahara, Mako, Kretz, Oliver, Küttner, Victoria, Suleiman, Hani, Kollipara, Laxmikanth, Zahedi, René P., Sickmann, Albert, Eimer, Stefan, Shaw, Andrey S., Kramer-Zucker, Albrecht, Hirano-Kobayashi, Mariko, Abe, Takaya, Aizawa, Shinichi, Grahammer, Florian, Hartleben, Björn, Dengjel, Jörn, Huber, Tobias B.

“…Podocytes form the outer part of the glomerular filter, where they have to withstand enormous transcapillary filtration forces driving glomerular filtration…”
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Mutations in glycyl-tRNA synthetase impair mitochondrial metabolism in neurons by Boczonadi, Veronika, Meyer, Kathrin, Gonczarowska-Jorge, Humberto, Griffin, Helen, Roos, Andreas, Bartsakoulia, Marina, Bansagi, Boglarka, Ricci, Giulia, Palinkas, Fanni, Zahedi, René P, Bruni, Francesco, Kaspar, Brian, Lochmüller, Hanns, Boycott, Kym M, Müller, Juliane S, Horvath, Rita

“…Abstract The nuclear-encoded glycyl-tRNA synthetase gene (GARS) is essential for protein translation in both cytoplasm and mitochondria. In contrast, different…”
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Toward the Complete Yeast Mitochondrial Proteome:  Multidimensional Separation Techniques for Mitochondrial Proteomics by Reinders, Joerg, Zahedi, René P, Pfanner, Nikolaus, Meisinger, Chris, Sickmann, Albert

“…Proteomic analyses of different subcellular compartments, so-called organellar proteomics, facilitate the understanding of cellular functions on a molecular…”
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Combining De Novo Peptide Sequencing Algorithms, A Synergistic Approach to Boost Both Identifications and Confidence in Bottom-up Proteomics by Blank-Landeshammer, Bernhard, Kollipara, Laxmikanth, Biß, Karsten, Pfenninger, Markus, Malchow, Sebastian, Shuvaev, Konstantin, Zahedi, René P, Sickmann, Albert

“…Complex mass spectrometry based proteomics data sets are mostly analyzed by protein database searches. While this approach performs considerably well for…”
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Discovery-Based Proteomics Identify Skeletal Muscle Mitochondrial Alterations as an Early Metabolic Defect in a Mouse Model of β-Thalassemia by Reboucas, Patricia, Fillebeen, Carine, Botta, Amy, Cleverdon, Riley, Steele, Alexandra P, Richard, Vincent, Zahedi, René P, Borchers, Christoph H, Burelle, Yan, Hawke, Thomas J, Pantopoulos, Kostas, Sweeney, Gary

“…Although metabolic complications are common in thalassemia patients, there is still an unmet need to better understand underlying mechanisms. We used unbiased…”
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The Deubiquitylase Otub1 Regulates the Chemotactic Response of Splenic B Cells by Modulating the Stability of the γ-Subunit Gng2 by Luo, Vincent M, Shen, Connie, Worme, Samantha, Bhagrath, Aanya, Simo-Cheyou, Estelle, Findlay, Steven, Hébert, Steven, Wai Lam Poon, William, Aryanpour, Zahra, Zhang, Thomas, Zahedi, René P, Boulais, Jonathan, Buchwald, Zachary S, Borchers, Christoph H, Côté, Jean-Francois, Kleinman, Claudia L, Mandl, Judith N, Orthwein, Alexandre

“…The ubiquitin proteasome system performs the covalent attachment of lysine 48-linked polyubiquitin chains to substrate proteins, thereby targeting them for…”
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