Search Results - "Zahedi, Kamyar"

Pathogenesis of Hypertension in Metabolic Syndrome: The Role of Fructose and Salt by Soleimani, Manoocher, Barone, Sharon, Luo, Henry, Zahedi, Kamyar

“…Metabolic syndrome is manifested by visceral obesity, hypertension, glucose intolerance, hyperinsulinism, and dyslipidemia. According to the CDC, metabolic…”
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Carbonic Anhydrase 2 Deletion Delays the Growth of Kidney Cysts Whereas Foxi1 Deletion Completely Abrogates Cystogenesis in TSC by Barone, Sharon, Zahedi, Kamyar, Brooks, Marybeth, Soleimani, Manoocher

“…Tuberous sclerosis complex (TSC) presents with renal cysts and benign tumors, which eventually lead to kidney failure. The factors promoting kidney cyst…”
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Polyamine Catabolism in Acute Kidney Injury by Zahedi, Kamyar, Barone, Sharon, Soleimani, Manoocher

“…Acute kidney injury (AKI) refers to an abrupt decrease in kidney function. It affects approximately 7% of all hospitalized patients and almost 35% of intensive…”
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Kidney Injury in COVID-19: Epidemiology, Molecular Mechanisms and Potential Therapeutic Targets by Teixeira, J Pedro, Barone, Sharon, Zahedi, Kamyar, Soleimani, Manoocher

“…As of December 2021, SARS-CoV-2 had caused over 250 million infections and 5 million deaths worldwide. Furthermore, despite the development of highly effective…”
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Polyamines and Their Metabolism: From the Maintenance of Physiological Homeostasis to the Mediation of Disease by Zahedi, Kamyar, Barone, Sharon, Soleimani, Manoocher

“…The polyamines spermidine and spermine are positively charged aliphatic molecules. They are critical in the regulation of nucleic acid and protein structures,…”
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Potentiation of the effect of thiazide derivatives by carbonic anhydrase inhibitors: molecular mechanisms and potential clinical implications by Zahedi, Kamyar, Barone, Sharon, Xu, Jie, Soleimani, Manoocher

“…Carbonic anhydrase inhibitors (CAI) are mild diuretics, hence not widely used in fluid overloaded states. They are however the treatment of choice for certain…”
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Double knockout of pendrin and Na-Cl cotransporter (NCC) causes severe salt wasting, volume depletion, and renal failure by Soleimani, Manoocher, Barone, Sharon, Xu, Jie, Shull, Gary E, Siddiqui, Faraz, Zahedi, Kamyar, Amlal, Hassane

“…The Na-Cl cotransporter (NCC), which is the target of inhibition by thiazides, is located in close proximity to the chloride-absorbing transporter pendrin in…”
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Kidney intercalated cells and the transcription factor FOXi1 drive cystogenesis in tuberous sclerosis complex by Barone, Sharon, Zahedi, Kamyar, Brooks, Marybeth, Henske, Elizabeth P., Yang, Yirong, Zhang, Erik, Bissler, John J., Yu, Jane J., Soleimani, Manoocher

“…Tuberous sclerosis complex (TSC) is caused by mutations in either TSC1 or TSC2 genes and affects multiple organs, including kidney, lung, and brain. In the…”
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Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery by Mishra, Jaya, Dent, Catherine, Tarabishi, Ridwan, Mitsnefes, Mark M, Ma, Qing, Kelly, Caitlin, Ruff, Stacey M, Zahedi, Kamyar, Shao, Mingyuan, Bean, Judy, Mori, Kiyoshi, Barasch, Jonathan, Devarajan, Prasad

“…The scarcity of early biomarkers for acute renal failure has hindered our ability to launch preventive and therapeutic measures for this disorder in a timely…”
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Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury by MISHRA, Jaya, QING MA, PRADA, Anne, MITSNEFES, Mark, ZAHEDI, Kamyar, JUN YANG, BARASCH, Jonathan, DEVARAJAN, Prasad

“…Acute renal failure (ARF) secondary to ischemic injury remains a common and potentially devastating problem. A transcriptome-wide interrogation strategy was…”
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Slc4a8 in the Kidney: Expression, Subcellular Localization and Role in Salt Reabsorption by Xu, Jie, Barone, Sharon, Zahedi, Kamyar, Brooks, Marybeth, Soleimani, Manoocher

“…Background/Aims: The sodium-dependent bicarbonate transporter Slc4a8 (a.k.a NDCBE) mediates the co-transport of sodium and bicarbonate in exchange for…”
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Probenecid Pre-treatment Downregulates the Kidney Cl-/HCO3- Exchanger (Pendrin) and Potentiates Hydrochlorothiazide-Induced Diuresis by Barone, Sharon, Xu, Jie, Zahedi, Kamyar, Brooks, Marybeth, Soleimani, Manoocher

“…Background: Probenecid is a uricosuric agent that in addition to exerting a positive ionotropic effect in the heart, blocks the ATP transporter Pannexin 1 and…”
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Renal Transcriptome and Metabolome in Mice with Principal Cell-Specific Ablation of the Tsc1 Gene: Derangements in Pathways Associated with Cell Metabolism, Growth and Acid Secretion by Zahedi, Kamyar, Barone, Sharon, Brooks, Marybeth, Murray Stewart, Tracy, Casero, Jr, Robert A, Soleimani, Manoocher

“…Tuberous sclerosis complex (TSC) is caused by mutations in the hamartin ( ) or tuberin ( ) genes. Using a mouse model of TSC renal cystogenesis that we have…”
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Downregulation of the Cl-/HCO3-Exchanger Pendrin in Kidneys of Mice with Cystic Fibrosis: Role in the Pathogenesis of Metabolic Alkalosis by Varasteh Kia, Mujan, Barone, Sharon, McDonough, Alicia A., Zahedi, Kamyar, Xu, Jie, Soleimani, Manoocher

“…Background/Aims: Patients with cystic fibrosis (CF) are prone to the development of metabolic alkalosis; however, the pathogenesis of this life threatening…”
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The Role of Epithelial Sodium Channel ENaC and the Apical Cl-/HCO3- Exchanger Pendrin in Compensatory Salt Reabsorption in the Setting of Na-Cl Cotransporter (NCC) Inactivation by Patel-Chamberlin, Mina, Varasteh Kia, Mujan, Xu, Jie, Barone, Sharon, Zahedi, Kamyar, Soleimani, Manoocher

“…The absence of NCC does not cause significant salt wasting in NCC deficient mice under basal conditions. We hypothesized that ENaC and pendrin play important…”
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Activation of endoplasmic reticulum stress response by enhanced polyamine catabolism is important in the mediation of cisplatin-induced acute kidney injury by Zahedi, Kamyar, Barone, Sharon, Destefano-Shields, Christina, Brooks, Marybeth, Murray-Stewart, Tracy, Dunworth, Matthew, Li, Weimin, Doherty, Joanne R, Hall, Mark A, Smith, Roger D, Cleveland, John L, Casero, Jr, Robert A, Soleimani, Manoocher

“…Cisplatin-induced nephrotoxicity limits its use in many cancer patients. The expression of enzymes involved in polyamine catabolism, spermidine/spermine…”
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The non-diuretic hypotensive effects of thiazides are enhanced during volume depletion states by Alshahrani, Saeed, Rapoport, Robert M, Zahedi, Kamyar, Jiang, Min, Nieman, Michelle, Barone, Sharon, Meredith, Andrea L, Lorenz, John N, Rubinstein, Jack, Soleimani, Manoocher

“…Thiazide derivatives including Hydrochlorothiazide (HCTZ) represent the most common treatment of mild to moderate hypertension. Thiazides initially enhance…”
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Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia by Zahedi, Kamyar, Brooks, Marybeth, Barone, Sharon, Rahmati, Negah, Murray Stewart, Tracy, Dunworth, Matthew, Destefano-Shields, Christina, Dasgupta, Nupur, Davidson, Steve, Lindquist, Diana M, Fuller, Christine E, Smith, Roger D, Cleveland, John L, Casero, Jr, Robert A, Soleimani, Manoocher

“…Polyamine catabolism plays a key role in maintaining intracellular polyamine pools, yet its physiological significance is largely unexplored. Here, we report…”
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Identification of IQGAP1 as a SLC26A4 (Pendrin)-Binding Protein in the Kidney by Xu, Jie, Barone, Sharon, Varasteh Kia, Mujan, Holliday, L Shannon, Zahedi, Kamyar, Soleimani, Manoocher

“…Several members of the SLC26A family of transporters, including SLC26A3 (DRA), SLC26A5 (prestin), SLC26A6 (PAT-1; CFEX) and SLC26A9, form multi-protein…”
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Polyamine Catabolism and Its Role in Renal Injury and Fibrosis in Mice Subjected to Repeated Low-Dose Cisplatin Treatment by Zahedi, Kamyar, Barone, Sharon, Brooks, Marybeth, Stewart, Tracy Murray, Foley, Jackson R, Nwafor, Ashley, Casero, Jr, Robert A, Soleimani, Manoocher

“…Cisplatin, a chemotherapeutic agent, can cause nephrotoxic and ototoxic injuries. Using a mouse model of repeated low dose cisplatin (RLDC), we compared the…”
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