Search Results - "Zaharko, DS"

Liposomes and Local Hyperthermia: Selective Delivery of Methotrexate to Heated Tumors by Weinstein, J. N., Magin, R. L., Yatvin, M. B., Zaharko, D. S.

“…Liposomes with phase transitions a few degrees above physiological temperature delivered more than four times as much methotrexate to murine tumors heated to…”
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Augmentation of natural killer activity, induction of IFN and development tumor immunity during the successful treatment of established murine renal cancer using flavone acetic acid and IL-2 by Hornung, RL, Back, TC, Zaharko, DS, Urba, WJ, Longo, DL, Wiltrout, RH

“…The investigational drug flavone acetic acid (FAA) has been previously shown to systemically augment NK activity in vivo in normal mice within 24 h of i.p. or…”
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Treatment of solid L1210 murine tumors with local hyperthermia and temperature-sensitive liposomes containing methotrexate by Weinstein, J N, Magin, R L, Cysyk, R L, Zaharko, D S

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Differences in DNA damage produced by incorporation of 5-aza-2'-deoxycytidine or 5,6-dihydro-5-azacytidine into DNA of mammalian cells by COVEY, J. M, D'INCALCI, M, TILCHEN, E. J, ZAHARKO, D. S, KOHN, K. W

“…The effects of 5-aza-2'-deoxycytidine (aza-dCyd) and 5,6-dihydro-5-azacytidine (H2-aza-Cyd) on the integrity of DNA from several mammalian cell lines were…”
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Chloroquinoxaline sulfonamide : a sulfanilamide antitumor agent entering clinical trials by FISHERMAN, J. S, OSBORN, B. L, CHUN, H. G, PLOWMAN, J, SMITH, A. C, CHRISTIAN, M. C, ZAHARKO, D. S, SHOEMAKER, R. H

“…Chloroquinoxaline sulfonamide (CQS) has been developed to the clinical trial stage based on its activity in the Human Tumor Colony Forming Assay (HTCFA). In…”
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DNA alkali-labile sites induced by incorporation of 5-aza-2'-deoxycytidine into DNA of mouse leukemia L1210 cells by DINCALCI, M, COVEY, J. M, ZAHARKO, D. S, KOHN, K. W

“…The effects of 5-aza-2'-deoxycytidine on DNA in mouse L1210 leukemia cells were investigated using the alkaline elution technique. By comparing the DNA elution…”
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The reversal of methotrexate cytotoxicity to mouse bone marrow cells by leucovorin and nucleosides by Pinedo, H M, Zaharko, D S, Bull, J M, Chabner, B A

“…The cytotoxic effect of methotrexate (MTX) for mouse bone marrow cells has been studied by in vitro of the granulocyte precursor cell (CFU-C) in a medium…”
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Modification of chemotherapeutic effects on L1210 cells using hematoporphyrin and light by CREEKMORE, S. P, ZAHARKO, D. S

“…Tissue culture experiments were done to evaluate the possibility of modifying the response curves of phenylalanine mustard (LPAM) and actinomycin D on L1210…”
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Flavone acetic acid (LM 975, NSC 347512): a novel antitumor agent by O'DWYER, P. J, SHOEMAKER, D, LEYLAND-JONES, ZAHARKO, D. S, GRIESHABER, C, PLOWMAN, J, CORBETT, T, VALERIOTE, F, KING, S. A, CRADOCK, J, HOTH, D. F

“…Flavone acetic acid (FAA) is a synthetic flavonoid compound which has recently begun clinical trials as an antitumor agent based on its striking activity in…”
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Cyclopentenyl cytosine : interspecies predictions based on rodent plasma and urine kinetics by ZAHARKO, D. S, KELLEY, J. A, TOMASZEWSKI, J. E, HEGEDUS, L, HARTMAN, N. R

“…A hybrid compartmental-physiological model for cyclopentenyl cytosine (CPE-C) is designed on the basis of early limited rodent pharmacokinetic data…”
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Methotrexate pharmacokinetics by Bischoff, K B, Dedrick, R L, Zaharko, D S, Longstreth, J A

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Could interspecies differences in the protein binding of flavone acetic acid contribute to the failure to predict lack of efficacy in patients? by CASSIDY, J, KERR, D. J, SETANOIANS, A, ZAHARKO, D. S, KAYE, S. B

“…We investigated the differences in plasma protein binding of flavone acetic acid (FAA) in mice and men in an attempt to explain the inter-species differences…”
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Studies of a simplified plasma insulin immunoassaay using cellulose powder by Zaharko, D S, Beck, L V

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Transport and binding of methotrexate in vivo by Dedrick, R L, Zaharko, D S, Lutz, R J

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Observations on the effects of cyclophosphamide, phosphoramide mustard and some activated oxazaphosphorines on murine L1210 leukemia by Zaharko, D S, Covey, J M, Hörpel, G

“…The L1210 tumor system was used in vitro and in vivo in comparative studies with activated cyclophosphamide analogs, cyclophosphamide and phosphoramide…”
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The relative contribution of drug concentration and duration of exposure to mouse bone marrow toxicity during continuous methotrexate infusion by Pinedo, H M, Zaharko, D S, Bull, J, Chabner, B A

“…The effects of exposure of bone marrow to specific methotrexate (MTX) concentrations were studied by constant infusion of the drug into C57BL mice. The…”
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Experimental chemotherapy (L1210) with 5-aza-2'-deoxycytidine in combination with pyran copolymer (MVE-4), an immune adjuvant by Zaharko, D S, Covey, J M, Muneses, C C

“…The life-span of CDF1 (BALB/c X DBA/2)F1 mice that received intraperitoneal implants with 10(5) L1210 tumor cells was prolonged to 23 days (compared to 8 days…”
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Evidence for early recruitment of granulocyte precursors during high- dose methotrexate infusions in mice by Pinedo, HM, Chabner, BA, Zaharko, DS, Bull, JM

“…The effects of constant exposure to high concentrations of methotrexate in vivo on the committed stem cell (CFU-C) were studied by in vitro culture of mouse…”
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Clinical phase I-II and pharmacokinetic study of high-dose thymidine given by continuous intravenous infusion by Chiuten, D F, Wiernik, P H, Zaharko, D S, Edwards, L

“…High-dose thymidine (dThd) was given to 12 patients with advanced hematological and solid tumors. The dose schedule used was 75 g/sq m/day, given i.v…”
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Tissue distribution of folate antagonists by Oliverio, V T, Zaharko, D S

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