Search Results - "Zagribelnyy, Bogdan A"

The Efficacy of Aprotinin Combinations with Selected Antiviral Drugs in Mouse Models of Influenza Pneumonia and Coronavirus Infection Caused by SARS-CoV-2 by Ivashchenko, Andrey A, Zagribelnyy, Bogdan A, Ivanenkov, Yan A, Ivashchenko, Ilya A, Karapetian, Ruben N, Kravchenko, Dmitry V, Savchuk, Nikolay P, Yakubova, Elena V, Ivachtchenko, Alexandre V

“…The efficacy of aprotinin combinations with selected antiviral-drugs treatment of influenza virus and coronavirus (SARS-CoV-2) infection was studied in mice…”
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Are We Opening the Door to a New Era of Medicinal Chemistry or Being Collapsed to a Chemical Singularity? by Ivanenkov, Yan A, Zagribelnyy, Bogdan A, Aladinskiy, Vladimir A

“…The paradigm of "drug-like-ness" dramatically altered the behavior of the medicinal chemistry community for a long time. In recent years, scientists have…”
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Are We Opening the Door to a New Era of Medicinal Chemistry or Being Collapsed to a Chemical Singularity?: Perspective by Ivanenkov, Yan A, Zagribelnyy, Bogdan A, Aladinskiy, Vladimir A

“…The paradigm of “drug-like-ness” dramatically altered the behavior of the medicinal chemistry community for a long time. In recent years, scientists have…”
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Deep learning enables rapid identification of potent DDR1 kinase inhibitors by Zhavoronkov, Alex, Ivanenkov, Yan A., Aliper, Alex, Veselov, Mark S., Aladinskiy, Vladimir A., Aladinskaya, Anastasiya V., Terentiev, Victor A., Polykovskiy, Daniil A., Kuznetsov, Maksim D., Asadulaev, Arip, Volkov, Yury, Zholus, Artem, Shayakhmetov, Rim R., Zhebrak, Alexander, Minaeva, Lidiya I., Zagribelnyy, Bogdan A., Lee, Lennart H., Soll, Richard, Madge, David, Xing, Li, Guo, Tao, Aspuru-Guzik, Alán

“…We have developed a deep generative model, generative tensorial reinforcement learning (GENTRL), for de novo small-molecule design. GENTRL optimizes synthetic…”
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Synthesis, biological evaluation and in silico modeling of novel pan-genotypic NS5A inhibitors by Ivashchenko, Andrey A., Ivanenkov, Yan A., Aladinskiy, Vladimir A., Karapetian, Ruben N., Koryakova, Angela G., Ryakhovskiy, Alexey A., Mitkin, Oleg D., Kravchenko, Dmitry V., Savchuk, Nikolai P., Zagribelnyy, Bogdan A., Ivashchenko, Alexander V.

“…[Display omitted] •Novel picomolar pan-genotypic NS5A inhibitors.•Combinatorial synthesis, biological evaluation and in silico modeling.•Lead compound showed…”
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