Search Results - "Zagorski, W."

Inhibition of early T cell cytokine production by arsenic trioxide occurs independently of Nrf2 by VanDenBerg, Kelly R, Freeborn, Robert A, Liu, Sheng, Kennedy, Rebekah C, Zagorski, Joseph W, Rockwell, Cheryl E

“…Nuclear factor erythroid 2-related factor 2 (Nrf2) is a stress-activated transcription factor that induces a variety of cytoprotective genes. Nrf2 also…”
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CCR5 and Biological Complexity: The Need for Data Integration and Educational Materials to Address Genetic/Biological Reductionism at the Interface of Ethical, Legal, and Social Implications by Bauss, Jacob, Morris, Michele, Shankar, Rama, Olivero, Rosemary, Buck, Leah N, Stenger, Cynthia L, Hinds, David, Mills, Joshua, Eby, Alexandra, Zagorski, Joseph W, Smith, Caitlin, Cline, Sara, Hartog, Nicholas L, Chen, Bin, Huss, John, Carcillo, Joseph A, Rajasekaran, Surender, Bupp, Caleb P, Prokop, Jeremy W

“…In the age of genomics, public understanding of complex scientific knowledge is critical. To combat reductionistic views, it is necessary to generate and…”
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Utilization of a novel human hepatocyte-endothelial cell coculture model to determine differential toxicities of pyrrolizidine alkaloid food contaminants by Zagorski, Joseph W., Kaminski, Norbert E.

“…Pyrrolizidine alkaloids (PA) are comprised of a family of hundreds of metabolites, produced by plants as a mechanism to protect against herbivory. Upon…”
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When the weight of evidence does not weigh enough: EFSA’s draft scientific opinion on BPA by Zagorski, Joseph W, Kaminski, Norbert E

“…Abstract In November of 2021, the European Food Safety Authority (EFSA) released a draft scientific opinion on bisphenol A (BPA) exposure and health outcomes…”
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Establishment of a point of departure for CBD hepatotoxicity employing human HepaRG spheroids by Li, Jinpeng, Zagorski, Joseph W., Kaminski, Norbert E.

“…The United States Food and Drug Administration recently approved the use of Cannabis sativa derived cannabidiol (CBD) in the treatment of Dravet Syndrome and…”
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Potyvirus terminal protein VPg, effector of host eukaryotic initiation factor eIF4E by Grzela, R., Strokovska, L., Andrieu, J.-P., Dublet, B., Zagorski, W., Chroboczek, J.

“…Potyvirus RNA contains at the 5′ end a covalently linked virus-encoded protein VPg, which is required for virus infectivity. This role has been attributed to…”
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The Nrf2 activator tBHQ inhibits T cell activation of primary human CD4 T cells by Turley, Alexandra E., Zagorski, Joseph W., Rockwell, Cheryl E.

“…•The food additive tBHQ activates the transcription factor Nrf2 in human PBMCs.•tBHQ inhibits production of IL-2 and IFN-γ in activated CD4 T cells.•The Nrf2…”
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Differential effects of the Nrf2 activators tBHQ and CDDO-Im on the early events of T cell activation by Zagorski, Joseph W., Turley, Alexandra E., Freeborn, Robert A., VanDenBerg, Kelly R., Dover, Heather E., Kardell, Brian R., Liby, Karen T., Rockwell, Cheryl E.

“…[Display omitted] We previously demonstrated that activation of the transcription factor, nuclear factor erythroid 2-related factor 2 (Nrf2) promotes CD4+ Th2…”
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Nrf2-Dependent and -Independent Effects of tert -Butylhydroquinone, CDDO-Im, and H 2 O 2 in Human Jurkat T Cells as Determined by CRISPR/Cas9 Gene Editing by Zagorski, Joseph W, Maser, Tyler P, Liby, Karen T, Rockwell, Cheryl E

“…Nuclear factor erythroid 2-related factor 2 (Nrf2) is a stress-activated transcription factor activated by stimuli such as electrophilic compounds and other…”
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The Nrf2 activator, tBHQ, differentially affects early events following stimulation of Jurkat cells by Zagorski, Joseph W, Turley, Alexandra E, Dover, Heather E, VanDenBerg, Kelly R, Compton, Jacob R, Rockwell, Cheryl E

“…Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that is activated by cellular stresses, such as oxidative compounds. After…”
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Restoration of secondary hairpin II is associated with restoration of infectivity of a non-viable recombinant viroid by Candresse, Thierry, Góra-Sochacka, Anna, Zagórski, Wlodzimiez

“…Mutagenesis and/or construction of recombinants by exchange of genomic regions between parental molecules constitute powerful tools for the study of viroids…”
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The genetic stability of potato spindle tuber viroid (PSTVd) molecular variants by GÓRA-SOCHACKA, ANNA, KIERZEK, ANDRZEJ, CANDRESSE, THIERRY, ZAGÓRSKI, WLODZIMIERZ

“…RNA viruses propagate as a population of genetically related entities composing a quasi-species. Specific representatives are the result of both a high…”
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Chronic low-level cadmium exposure in rats affects cytokine production by activated T cells by Turley, Alexandra E, Zagorski, Joseph W, Kennedy, Rebekah C, Freeborn, Robert A, Bursley, Jenna K, Edwards, Joshua R, Rockwell, Cheryl E

“…Cadmium is a toxic metal and common environmental contaminant. Chronic cadmium exposure results in kidney, bone, reproductive, and immune toxicity as well as…”
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Tobacco veinal necrosis determinants are unlikely to be located within the 5' and 3' terminal sequences of the potato virus Y genome by Chachulska, A.M, Chrzanowska, M, Robaglia, C, Zagorski, W

“…Three potato virus Y isolates, representatives of distinct PVY groups, identified in potato fields in northern Poland were submitted to biological and…”
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Genetic variability of potato spindle tuber viroid RNA replicon by Góra-Sochacka, A, Candresse, T, Zagórski, W

“…The genetic continuity of the potato spindle tuber viroid (PSTVd) genome was analysed after infection of tomato plants with cloned cDNAs of parental strains…”
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Democratic Breakdown in Paraguay and Venezuela: The Shape of Things to Come for Latin America? by ZAGORSKI, PAUL W.

“…The decade of the 1990s saw advances in democratization and civilian control of the armed forces in Latin America, but there are warning signs on the horizon…”
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Analysis of the population structure of three phenotypically different PSTVd isolates by Gora, A, Candresse, T, Zagorski, W

“…Phenotypically dissimilar greenhouse isolates from a Polish collection of potato spindle tuber viroid (PSTVd) were analysed. Partially purified PSTVd genomic…”
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Effect of genomic and subgenomic leader sequences of potato leafroll virus on gene expression by Juszczuk, Marek, Pączkowska, Elżbieta, Sadowy, Ewa, Zagórski, Włodzimierz, Hulanicka, Danuta M.

“…The effect of the genomic and subgenomic leader sequence of potato leafroll polerovirus on the efficiency of translation of the downstream located genes has…”
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Synthesis of full-length potyvirus cDNA copies suitable for the analysis of genome polymorphism by Chachulska, Anna Maria, Fakhfakh, Hatem, Robaglia, Christophe, Granier, Fabienne, Zagórski, Wlodzimierz, Vilaine, Françoise

“…New methods facilitating the synthesis and amplification of full-length cDNA copies of single-stranded viral RNA genomes have been developed. A method is…”
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Preparation and characteristics of a wheat embryo cell-free extract active in the synthesis of high molecular weight viral polypeptides by Zagorski, W

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