Search Results - "Zagorodnyuk, Vladimir"

Melatonin inhibits muscular-mucosal stretch-sensitive bladder afferents via the MT2 receptors by Ramsay, Stewart, Zagorodnyuk, Vladimir

“…Melatonin is a circadian rhythm regulator capable of controlling a variety of physiological processes in the body. It predominantly acts via the melatonin 1…”
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Time-of-day dependent changes in guinea pig bladder afferent mechano-sensitivity by Christie, Stewart, Zagorodnyuk, Vladimir

“…The voiding of urine has a clear circadian rhythm with increased voiding during active phases and decreased voiding during inactive phases. Bladder spinal…”
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Extrinsic primary afferent signalling in the gut by Brookes, Simon J. H., Spencer, Nick J., Costa, Marcello, Zagorodnyuk, Vladimir P.

“…The gut is innervated by many types of extrinsic sensory neurons, and little consensus exists about the different classes that these afferents might belong to…”
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Endocannabinoids in Bladder Sensory Mechanisms in Health and Diseases by Christie, Stewart, Brookes, Simon, Zagorodnyuk, Vladimir

“…The recent surge in research on cannabinoids may have been fueled by changes in legislation in several jurisdictions, and by approval for the use of…”
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Translating peripheral bladder afferent mechanosensitivity to neuronal activation within the lumbosacral spinal cord of mice by Grundy, Luke, Harrington, Andrea M., Caldwell, Ashlee, Castro, Joel, Staikopoulos, Vasiliki, Zagorodnyuk, Vladimir P., Brookes, Simon J.H., Spencer, Nick J., Brierley, Stuart M.

“…Primary afferent neurons transduce distension of the bladder wall into action potentials that are relayed into the spinal cord and brain, where autonomic…”
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Identifying unique subtypes of spinal afferent nerve endings within the urinary bladder of mice by Spencer, Nick J., Greenheigh, Sarah, Kyloh, Melinda, Hibberd, Tim J., Sharma, Harman, Grundy, Luke, Brierley, Stuart M., Harrington, Andrea M., Beckett, Elizabeth A., Brookes, Simon J., Zagorodnyuk, Vladimir P.

“…Spinal afferent neurons are responsible for the transduction and transmission of noxious (painful) stimuli and innocuous stimuli that do not reach conscious…”
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Circadian rhythms in colonic function by Hibberd, Timothy J, Ramsay, Stewart, Spencer-Merris, Phaedra, Dinning, Phil G, Zagorodnyuk, Vladimir P, Spencer, Nick J

“…A rhythmic expression of clock genes occurs within the cells of multiple organs and tissues throughout the body, termed "peripheral clocks." Peripheral clocks…”
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Characterization of putative interneurons in the myenteric plexus of human colon by Humenick, Adam, Chen, Bao Nan, Wattchow, David A., Zagorodnyuk, Vladimir P., Dinning, Phil G., Spencer, Nick J., Costa, Marcello, Brookes, Simon J. H.

“…Background The enteric nervous system contains multiple classes of neurons, distinguishable by morphology, immunohistochemical markers, and projections;…”
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Characterization of projections of longitudinal muscle motor neurons in human colon by Humenick, Adam, Chen, Bao Nan, Lauder, Chris I. W., Wattchow, David A., Zagorodnyuk, Vladimir P., Dinning, Phil G., Spencer, Nick J., Costa, Marcello, Brookes, Simon J. H.

“…Background The enteric nervous system contains inhibitory and excitatory motor neurons which modulate smooth muscle contractility. Cell bodies of longitudinal…”
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Mechanisms underlying distension-evoked peristalsis in guinea pig distal colon: is there a role for enterochromaffin cells? by Spencer, Nick J, Nicholas, Sarah J, Robinson, Lucy, Kyloh, Melinda, Flack, Nicholas, Brookes, Simon J, Zagorodnyuk, Vladimir P, Keating, Damien J

“…The mechanisms underlying distension-evoked peristalsis in the colon are incompletely understood. It is well known that, following colonic distension,…”
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Functional changes in low- and high-threshold afferents in obstruction-induced bladder overactivity by Zagorodnyuk, Vladimir P, Keightley, Lauren J, Brookes, Simon J H, Spencer, Nick J, Costa, Marcello, Nicholas, Sarah J

“…Neural mechanisms of lower urinary tract symptoms in obstruction-induced bladder overactivity remain unclear. We made the first single unit recordings from…”
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Roles of three distinct neurogenic motor patterns during pellet propulsion in guinea‐pig distal colon by Costa, Marcello, Keightley, Lauren J., Wiklendt, Lukasz, Hibberd, Timothy J., Arkwright, John W., Omari, Taher, Wattchow, David A., Zagorodnyuk, Vladimir, Brookes, Simon J. H., Dinning, Phil G., Spencer, Nick J.

“…Key points Enteric neural circuits enable isolated preparations of guinea‐pig distal colon to propel solid and fluid contents by a self‐sustaining…”
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Morphological and neurochemical characterisation of anterogradely labelled spinal sensory and autonomic nerve endings in the mouse bladder by Sharma, Harman, Kyloh, Melinda, Brookes, Simon J.H., Costa, Marcello, Spencer, Nick J., Zagorodnyuk, Vladimir P.

“…The bladder is innervated by axons of sympathetic and parasympathetic efferent nerves, and by spinal afferent neurons. The objective was to characterise…”
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Disengaging spinal afferent nerve communication with the brain in live mice by Kyloh, Melinda A., Hibberd, Timothy J., Castro, Joel, Harrington, Andrea M., Travis, Lee, Dodds, Kelsi N., Wiklendt, Lukasz, Brierley, Stuart M., Zagorodnyuk, Vladimir P., Spencer, Nick J.

“…Our understanding of how abdominal organs (like the gut) communicate with the brain, via sensory nerves, has been limited by a lack of techniques to…”
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Identification of the visceral pain pathway activated by noxious colorectal distension in mice by Kyloh, Melinda, Nicholas, Sarah, Zagorodnyuk, Vladimir P, Brookes, Simon J, Spencer, Nick J

“…In patients with irritable bowel syndrome, visceral pain is evoked more readily following distension of the colorectum. However, the identity of extrinsic…”
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Loss of visceral pain following colorectal distension in an endothelin‐3 deficient mouse model of Hirschsprung's disease by Zagorodnyuk, Vladimir P., Kyloh, Melinda, Nicholas, Sarah, Peiris, Heshan, Brookes, Simon J., Chen, Bao Nan, Spencer, Nick J.

“…Non‐technical summary  The endothelin‐3 (ET‐3) gene is essential for the development of the enteric nervous system in the gastrointestinal tract of mammals,…”
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Intraganglionic laminar endings are mechano-transduction sites of vagal tension receptors in the guinea-pig stomach by Zagorodnyuk, Vladimir P., Chen, Bao Nan, Brookes, Simon J. H.

“…Distension-sensitive vagal afferent fibres from the cardiac region of the guinea-pig stomach were recorded extracellularly, then filled with biotinamide, using…”
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Neurochemical characterization of extrinsic nerves in myenteric ganglia of the guinea pig distal colon by Chen, Bao Nan, Sharrad, Dale F., Hibberd, Timothy J., Zagorodnyuk, Vladimir P., Costa, Marcello, Brookes, Simon J.H.

“…ABSTRACT Extrinsic nerves to the gut influence the absorption of water and electrolytes and expulsion of waste contents, largely via regulation of enteric…”
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Mechanotransduction and chemosensitivity of two major classes of bladder afferents with endings in the vicinity to the urothelium by Zagorodnyuk, Vladimir P., Brookes, Simon J. H., Spencer, Nick J., Gregory, Sarah

“…The guinea pig bladder is innervated by at least five distinct major classes of extrinsic sensory neurons. In this study, we have examined the mechanisms of…”
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Properties of the major classes of mechanoreceptors in the guinea pig bladder by Zagorodnyuk, Vladimir P., Gibbins, Ian L., Costa, Marcello, Brookes, Simon J. H., Gregory, Sarah J.

“…Sensory neurons represent an attractive target for pharmacological treatment of various bladder disorders. However the properties of major classes of…”
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