Search Results - "Zaghlula, Manar"

Specification of select hypothalamic circuits and innate behaviors by the embryonic patterning gene Dbx1 by Sokolowski, Katie, Esumi, Shigeyuki, Hirata, Tsutomu, Kamal, Yasman, Tran, Tuyen, Lam, Andrew, Oboti, Livio, Brighthaupt, Sherri-Chanelle, Zaghlula, Manar, Martinez, Jennifer, Ghimbovschi, Svetlana, Knoblach, Susan, Pierani, Alessandra, Tamamaki, Nobuaki, Shah, Nirao M., Jones, Kevin S., Corbin, Joshua G.

“…The hypothalamus integrates information required for the production of a variety of innate behaviors such as feeding, mating, aggression and predator…”
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A roadmap for affordable genetic medicines by Kliegman, Melinda, Zaghlula, Manar, Abrahamson, Susan, Esensten, Jonathan H., Wilson, Ross C., Urnov, Fyodor D., Doudna, Jennifer A.

“…Twenty genetic therapies have been approved by the US Food and Drug Administration to date, a number that now includes the first CRISPR genome-editing therapy…”
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Governing with public engagement: an anticipatory approach to human genome editing by Barlevy, Dorit, Juengst, Eric, Kahn, Jeffrey, Moreno, Jonathan, Lambert, Lauren, Charo, Alta, Chneiweiss, Hervé, Farooque, Mahmud, Guston, David H, Hyun, Insoo, Knoepfler, Paul S, Selin, Cynthia, Wilbanks, Rebecca, Zaghlula, Manar, Scott, Christopher Thomas

“…In response to calls for public engagement on human genome editing (HGE), which intensified after the 2018 He Jiankui scandal that resulted in the implantation…”
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An RNA interference screen identifies druggable regulators of MeCP2 stability by Lombardi, Laura M, Zaghlula, Manar, Sztainberg, Yehezkel, Baker, Steven A, Klisch, Tiemo J, Tang, Amy A, Huang, Eric J, Zoghbi, Huda Y

“…Alterations in gene dosage due to copy number variation are associated with autism spectrum disorder, intellectual disability (ID), and other psychiatric…”
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The MID1 E3 ligase catalyzes the polyubiquitination of Alpha4 (α4), a regulatory subunit of protein phosphatase 2A (PP2A): novel insights into MID1-mediated regulation of PP2A by Du, Haijuan, Huang, Yongzhao, Zaghlula, Manar, Walters, Erica, Cox, Timothy C, Massiah, Michael A

“…Alpha4 (α4) is a key regulator of protein phosphatase 2A (PP2A) and mTOR in steps essential for cell-cycle progression. α4 forms a complex with PP2A and MID1,…”
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Current clinical evidence does not support a link between TBL1XR1 and Rett syndrome: Description of one patient with Rett features and a novel mutation in TBL1XR1, and a review of TBL1XR1 phenotypes by Zaghlula, Manar, Glaze, Daniel G., Enns, Gregory M., Potocki, Lorraine, Schwabe, Aloysia L., Suter, Bernhard

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The MID1 E3 Ligase Catalyzes the Polyubiquitination of Alpha4 (α4), a Regulatory Subunit of Protein Phosphatase 2A (PP2A) by Du, Haijuan, Huang, Yongzhao, Zaghlula, Manar, Walters, Erica, Cox, Timothy C., Massiah, Michael A.

“…Alpha4 (α4) is a key regulator of protein phosphatase 2A (PP2A) and mTOR in steps essential for cell-cycle progression. α4 forms a complex with PP2A and MID1,…”
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