Search Results - "Zager, Richard A"

Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease by Ruiz, Stacey, Pergola, Pablo E, Zager, Richard A, Vaziri, Nosratola D

“…Oxidative stress and inflammation are mediators in the development and progression of chronic kidney disease (CKD) and its complications, and they are…”
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Acute unilateral ischemic renal injury induces progressive renal inflammation, lipid accumulation, histone modification, and "end-stage" kidney disease by Zager, Richard A, Johnson, Ali C M, Becker, Kirsten

“…There is an emerging concept in clinical nephrology that acute kidney injury (AKI) can initiate chronic kidney disease (CKD). However, potential mechanisms by…”
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Oxidant‐ induced preconditioning: A pharmacologic approach for triggering renal ‘self defense’ by Zager, Richard A.

“…Acute kidney injury (AKI) is a common event, occurring in ~5% and ~35% of hospitalized and ICU patients, respectively. The development of AKI portends an…”
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Renal Cortical Lactate Dehydrogenase: A Useful, Accurate, Quantitative Marker of In Vivo Tubular Injury and Acute Renal Failure by Zager, Richard A, Johnson, Ali C M, Becker, Kirsten

“…Studies of experimental acute kidney injury (AKI) are critically dependent on having precise methods for assessing the extent of tubular cell death. However,…”
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MCP-1 Gene Activation Marks Acute Kidney Injury by MUNSHI, Raj, JOHNSON, Ali, SIEW, Edward D, ALP IKIZLER, T, WARE, Lorraine B, WURFEL, Mark M, HIMMELFARB, Jonathan, ZAGER, Richard A

“…Monocyte chemoattractant protein 1 (MCP-1) mediates acute ischemic and toxic kidney injury, but whether this can be used as a biomarker of acute kidney injury…”
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Distinct patterns of transcriptional and epigenetic alterations characterize acute and chronic kidney injury by Sharifian, Roya, Okamura, Daryl M., Denisenko, Oleg, Zager, Richard A., Johnson, Ali, Gharib, Sina A., Bomsztyk, Karol

“…Acute kidney injury (AKI) and chronic kidney disease (CKD) are considered early and late phases of a pathologic continuum of interconnected disease states…”
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BRG1 Increases Transcription of Proinflammatory Genes in Renal Ischemia by NAITO, Masayo, ZAGER, Richard A, BOMSZTYK, Karol

“…Acute kidney injury stimulates renal production of inflammatory mediators, including TNF-alpha and monocyte chemoattractant protein 1 (MCP-1). These responses…”
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Renal cortical albumin gene induction and urinary albumin excretion in response to acute kidney injury by Ware, Lorraine B, Johnson, Ali C M, Zager, Richard A

“…This study evaluated the potential utility of albuminuria as a "biomarker" of acute kidney injury (AKI) and tested whether AKI induces renal expression of the…”
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Progression from acute kidney injury to chronic kidney disease: clinical and experimental insights and queries by Zager, Richard A

“…There is an increasing number of clinical studies suggesting that acute kidney injury (AKI) can be complicated by the onset of progressive renal disease…”
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Early loss of glutathione ‐s‐ transferase (GST) activity during diverse forms of acute renal tubular injury by Zager, Richard A., Johnson, Ali C. M.

“…Glutathione‐S‐transferases (GSTs) are a diverse group of phase II detoxification enzymes which primarily evoke tissue protection via glutathione conjugation to…”
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An evaluation of the antioxidant protein α1-microglobulin as a renal tubular cytoprotectant by Zager, Richard A, Johnson, Ali C M, Frostad, Kirsten

“…α1-Microglobulin (A1M) is a low-molecular-weight heme-binding antioxidant protein that is readily filtered by the glomerulus and reabsorbed by proximal…”
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Renal cortical hemopexin accumulation in response to acute kidney injury by Zager, Richard A, Johnson, Ali C M, Becker, Kirsten

“…Hemopexin (Hpx) is a liver-generated acute phase reactant that binds and neutralizes prooxidant free heme. This study tested whether acute kidney injury (AKI)…”
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Tin Protoporphyrin Activates the Oxidant Dependent NRF2 – Cytoprotective Pathway and Mitigates Acute Kidney Injury by Johnson, Ali CM., BS, Delrow, Jeff J., PhD, Zager, Richard A., MD

“…Abstract Tin protoporphyrin (SnPP), a heme oxygenase (HO) inhibitor, can paradoxically protect against diverse forms of AKI. This study sought potential…”
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Parenteral iron formulations differentially affect MCP-1, HO-1, and NGAL gene expression and renal responses to injury by Johnson, Ali C M, Becker, Kirsten, Zager, Richard A

“…Despite their prooxidant effects, ferric iron compounds are routinely administered to patients with renal disease to correct Fe deficiency. This study assessed…”
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Rapid renal alpha-1 antitrypsin gene induction in experimental and clinical acute kidney injury by Zager, Richard A, Johnson, Ali C M, Frostad, Kirsten B

“…Alpha-1-antitrypsin (AAT) is a hepatic stress protein with protease inhibitor activity. Recent evidence indicates that ischemic or toxic injury can evoke…”
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The NRF2 stimulating agent, tin protoporphyrin, activates protective cytokine pathways in healthy human subjects and in patients with chronic kidney disease by Zager, Richard A., Johnson, Ali C. M.

“…Background Tin protoporphyrin (SnPP), a heme oxygenase 1 (HO‐1) inhibitor, triggers adaptive tissue responses that confer potent protection against acute…”
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Parenteral Iron Compounds: Potent Oxidants but Mainstays of Anemia Management in Chronic Renal Disease by Zager, Richard A

“…Ferric iron (Fe)-carbohydrate complexes are widely used for treating Fe deficiency in patients who are unable to meet their Fe requirements with oral…”
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Renal Cortical Pyruvate Depletion during AKI by ZAGER, Richard A, JOHNSON, Ali C. M, BECKER, Kirsten

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Levosimendan protects against experimental endotoxemic acute renal failure by Zager, Richard A, Johnson, Ali C, Lund, Steve, Hanson, Sherry Y, Abrass, Christine K

“…Endotoxemia induces a hemodynamic form of acute renal failure (ARF; renal vasoconstriction +/- reduced glomerular ultrafiltration coefficient, K(f); minimal/no…”
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Progressive histone alterations and proinflammatory gene activation: consequences of heme protein/iron-mediated proximal tubule injury by Zager, Richard A, Johnson, Ali C M

“…Rhabdomyolysis (Fe)-induced acute renal failure (ARF) causes renal inflammation, and, with repetitive insults, progressive renal failure can result. To gain…”
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