Search Results - "Zafrani, Yossi"

Difluoromethyl Bioisostere: Examining the “Lipophilic Hydrogen Bond Donor” Concept by Zafrani, Yossi, Yeffet, Dina, Sod-Moriah, Gali, Berliner, Anat, Amir, Dafna, Marciano, Daniele, Gershonov, Eytan, Saphier, Sigal

“…There is a growing interest in organic compounds containing the difluoromethyl group, as it is considered a lipophilic hydrogen bond donor that may act as a…”
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Utilizing the CF2H moiety as a H-bond-donating group in drug discovery by Zafrani, Yossi, Saphier, Sigal, Gershonov, Eytan

“…Since there is a mutual influence between this moiety and other attached functional groups (FGs) in the molecule, CF2H has additional attractive properties…”
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Diethyl bromodifluoromethylphosphonate: a highly efficient and environmentally benign difluorocarbene precursor by Zafrani, Yossi, Sod-Moriah, Gali, Segall, Yoffi

“…A convenient method for the difluoromethylation of phenols and thiophenols, using diethyl bromodifluoromethylphosphonate (1) as a difluorocarbene precursor, is…”
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Bis-resorcin[4]arene Selectively Forms Hexameric Capsules in Apolar Solvents: Evidence from Diffusion NMR by Horin, Inbar, Adiri, Tal, Zafrani, Yossi, Cohen, Yoram

“…Bis-resorcin­[4]­arene 2 connected by its lower rims was synthesized via click chemistry and found, by diffusion NMR, to self-assemble quantitatively, despite…”
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pH‐Responsive Pillar[6]arene‐based Water‐Soluble Supramolecular Hexagonal Boxes by Kaizerman‐Kane, Dana, Hadar, Maya, Tal, Noam, Dobrovetsky, Roman, Zafrani, Yossi, Cohen, Yoram

“…We describe the preparation of the first water‐soluble pH‐responsive supramolecular hexagonal boxes (SHBs) based on multiple charge‐assisted hydrogen bonds…”
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Synthesis, Characterization, and Reactivity of Thermally Stable Anhydrous Quaternary Ammonium Fluorides by Elias, Shlomi, Karton-Lifshin, Naama, Yehezkel, Lea, Ashkenazi, Nissan, Columbus, Ishay, Zafrani, Yossi

“…The synthesis and properties of a new class of anhydrous quaternary ammonium fluorides, based on the rigid skeleton azabicyclo[2.2.2]­octane, is described…”
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Pillararene‐Based Two‐Component Thixotropic Supramolecular Organogels: Complementarity and Multivalency as Prominent Motifs by Zafrani, Yossi, Kaizerman, Dana, Hadar, Maya, Bigan, Nitzan, Granot, Eran, Ghosh, Moumita, Adler‐Abramovich, Lihi, Patolsky, Fernando, Cohen, Yoram

“…Rationally designed two‐component supramolecular organogels based on multiple chemical interactions between percarboxylato‐ and peramino‐pillararenes are…”
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Species-specific lipophilicities of fluorinated diketones in complex equilibria systems and their potential as multifaceted reversible covalent warheads by Columbus, Ishay, Ghindes-Azaria, Lee, Herzog, Ido Michael, Blum, Eliav, Parvari, Galit, Eichen, Yoav, Cohen, Yoram, Gershonov, Eytan, Drug, Eyal, Saphier, Sigal, Elias, Shlomi, Smolkin, Boris, Zafrani, Yossi

“…Combined molecular, physicochemical and chemical properties of electrophilic warheads can be applied to create covalent drugs with diverse facets. Here we…”
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pH‐Responsive Pillar[6]arene‐based Water‐Soluble Supramolecular Hexagonal Boxes by Kaizerman‐Kane, Dana, Hadar, Maya, Tal, Noam, Dobrovetsky, Roman, Zafrani, Yossi, Cohen, Yoram

“…We describe the preparation of the first water‐soluble pH‐responsive supramolecular hexagonal boxes (SHBs) based on multiple charge‐assisted hydrogen bonds…”
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Novel synthetic approach in microwave-assisted solid-supported oxidations using ‘in situ’ generated molecular oxygen by Gershonov, Eytan, Katz, Esther, Karton, Yishai, Zafrani, Yossi

“…Three different types of oxidation reactions were carried out under microwave (MW) conditions in dry media, with nearly quantitative yield, using ‘in situ’,…”
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Calix[4, 5]tetrolarenes: A New Family of Macrocycles by Zafrani, Yossi, Cohen, Yoram

“…The facile and efficient one-step synthesis and the full characterization of novel π-electron rich macrocycles, calix-[n]­tetrolarenes (n = 4, 5), are…”
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CF2H, a Functional Group-Dependent Hydrogen-Bond Donor: Is It a More or Less Lipophilic Bioisostere of OH, SH, and CH3? by Zafrani, Yossi, Sod-Moriah, Gali, Yeffet, Dina, Berliner, Anat, Amir, Dafna, Marciano, Daniele, Elias, Shlomi, Katalan, Shahaf, Ashkenazi, Nissan, Madmon, Moran, Gershonov, Eytan, Saphier, Sigal

“…The effects of the CF2H moiety on H-bond (HB) acidity and lipophilicity of various compounds, when attached directly to an aromatic ring or to other functions…”
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Facile synthesis and rearrangement of propargylic trifluoromethanesulfinates by Braverman, Samuel, Pechenick, Tatiana, Zafrani, Yossi

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Temperature‐Dependent and pH‐Responsive Pillararene‐Based Complexes and Hydrogen‐Bond‐Based Supramolecular Pentagonal Boxes in Water by Hadar, Maya, Dana Kaizerman‐Kane, Zafrani, Yossi, Cohen, Yoram

“…Supramolecular systems in water are of paramount importance and those based on hydrogen bonds are both intriguing and scarce. Here, after studying the peculiar…”
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Software-Assisted Automated Detection and Identification of “Unknown” Analogues: Implementation on V‑Type Nerve Agents by Drug, Eyal, Gershonov, Eytan, Ashkenazi, Nissan, Zafrani, Yossi, Chen, Ravit, Dagan, Shai

“…V-type nerve agents are among the most toxic organophosphorus chemical warfare agents, and they are under strict regulation and supervision by the OPCW…”
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Synthesis, rearrangement and solvolysis of propargylic and allylic trifluoromethanesulfinates by Braverman, Samuel, Pechenick, Tatiana, Zafrani, Yossi

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Modulation of the H‑Bond Basicity of Functional Groups by α‑Fluorine-Containing Functions and its Implications for Lipophilicity and Bioisosterism by Zafrani, Yossi, Parvari, Galit, Amir, Dafna, Ghindes-Azaria, Lee, Elias, Shlomi, Pevzner, Alexander, Fridkin, Gil, Berliner, Anat, Gershonov, Eytan, Eichen, Yoav, Saphier, Sigal, Katalan, Shahaf

“…Modulation of the H-bond basicity (pK HB) of various functional groups (FGs) by attaching fluorine functions and its impact on lipophilicity and bioisosterism…”
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Temperature‐Dependent and pH‐Responsive Pillar[5]arene‐Based Complexes and Hydrogen‐Bond‐Based Supramolecular Pentagonal Boxes in Water by Hadar, Maya, Kaizerman‐Kane, Dana, Zafrani, Yossi, Cohen, Yoram

“…Supramolecular systems in water are of paramount importance and those based on hydrogen bonds are both intriguing and scarce. Here, after studying the peculiar…”
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Oxidative Detoxification of Sulfur-Containing Chemical Warfare Agents by Electrophilic Iodine by Smolkin, Boris, Levi, Noam, Karton-Lifshin, Naama, Yehezkel, Lea, Zafrani, Yossi, Columbus, Ishay

“…Mild oxidation of sulfur-containing chemical warfare agents was performed in organic medium by electrophilic iodine reagents. Kinetic experiments on sulfur…”
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Utilizing the CF 2 H moiety as a H-bond-donating group in drug discovery by Zafrani, Yossi, Saphier, Sigal, Gershonov, Eytan

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