Search Results - "Zafar, Atif"

Increased Reactive Oxygen Species Formation and Oxidative Stress in Rheumatoid Arthritis by Mateen, Somaiya, Moin, Shagufta, Khan, Abdul Qayyum, Zafar, Atif, Fatima, Naureen

“…Rheumatoid arthritis (RA) is an autoimmune inflammatory disorder. Highly reactive oxygen free radicals are believed to be involved in the pathogenesis of the…”
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Understanding the role of cytokines in the pathogenesis of rheumatoid arthritis by Mateen, Somaiya, Zafar, Atif, Moin, Shagufta, Khan, Abdul Qayyum, Zubair, Swaleha

“…Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease of unknown etiology. It is characterized by the presence of rheumatoid factor and…”
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Artificial Intelligence and the Future of Healthcare in Pakistan: Opportunities and Challenges by Zafar, Atif, Qazi, Ahmed, Siddiqui, Rehman

“…Artificial Intelligence (AI) is rapidly transforming healthcare across the world. However, in Pakistan, the use of AI in healthcare is still in its early…”
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Synthesis of novel coumarin nucleus-based DPA drug-like molecular entity: In vitro DNA/Cu(II) binding, DNA cleavage and pro-oxidant mechanism for anticancer action by Khan, Saman, Malla, Ali Mohammed, Zafar, Atif, Naseem, Imrana

“…Despite substantial research on cancer therapeutics, systemic toxicity and drug-resistance limits the clinical application of many drugs like cisplatin…”
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Redox cycling of copper by coumarin-di(2-picolyl)amine hybrid molecule leads to ROS-mediated modulation of redox scavengers, DNA damage and cell death in diethylnitrosamine induced hepatocellular carcinoma by Khan, Saman, Zafar, Atif, Naseem, Imrana

“…[Display omitted] •Coumarin based copper chelator (ligand-L) targets copper in cancer cells.•Ligand-L-Cu(II) interaction induces ROS generation in…”
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Cu(II)-coumestrol interaction leads to ROS-mediated DNA damage and cell death: a putative mechanism for anticancer activity by Zafar, Atif, Singh, Swarnendra, Naseem, Imrana

“…Phytoestrogens have attracted considerable interest as natural alternatives to hormone replacement therapy and their potential as cancer therapeutic agents…”
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CITED2 inhibits STAT1‐IRF1 signaling and atherogenesis by Zafar, Atif, Pong Ng, Hang, Diamond‐Zaluski, Rachel, Kim, Gun‐Dong, Ricky Chan, Ernest, Dunwoodie, Sally L., Smith, Jonathan D., Mahabeleshwar, Ganapati H.

“…Macrophages are the principal component of the innate immune system. They play very crucial and multifaceted roles in the pathogenesis of inflammatory vascular…”
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Deciphering the molecular mechanism underlying anticancer activity of coumestrol in triple-negative breast cancer cells by Zafar, Atif, Singh, Swarnendra, Satija, Yatendra Kumar, Saluja, Daman, Naseem, Imrana

“…Triple-negative breast cancer (TNBC) represents the highly aggressive subgroup of breast cancers with poor prognosis due to absence of estrogen receptor (ER)…”
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Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma by Polster, Sean P., Sharma, Anukriti, Tanes, Ceylan, Tang, Alan T., Mericko, Patricia, Cao, Ying, Carrión-Penagos, Julián, Girard, Romuald, Koskimäki, Janne, Zhang, Dongdong, Stadnik, Agnieszka, Romanos, Sharbel G., Lyne, Seán B., Shenkar, Robert, Yan, Kimberly, Lee, Cornelia, Akers, Amy, Morrison, Leslie, Robinson, Myranda, Zafar, Atif, Bittinger, Kyle, Kim, Helen, Gilbert, Jack A., Kahn, Mark L., Shen, Le, Awad, Issam A.

“…Cavernous angiomas (CA) are common vascular anomalies causing brain hemorrhage. Based on mouse studies, roles of gram-negative bacteria and altered intestinal…”
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Novel Non-Peptide Inhibitors against SmCL1 of Schistosoma mansoni: In Silico Elucidation, Implications and Evaluation via Knowledge Based Drug Discovery by Zafar, Atif, Ahmad, Sabahuddin, Rizvi, Asim, Ahmad, Masood

“…Schistosomiasis is a major endemic disease known for excessive mortality and morbidity in developing countries. Because praziquantel is the only drug available…”
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Two Birds with One Stone: NFAT1-MDM2 Dual Inhibitors for Cancer Therapy by Wang, Wei, Zafar, Atif, Rajaei, Mehrdad, Zhang, Ruiwen

“…The tumor suppressor p53 is believed to be the mostly studied molecule in modern biomedical research. Although p53 interacts with hundreds of molecules to…”
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Investigation of plugging performance and enhanced oil recovery of multi-scale polymer microspheres in low-permeability reservoirs by Wendong Wang, Xincheng Guo, Penghui Duan, Bo Kang, Da Zheng, Atif Zafar

“…Advanced water injection has become an effective method for developing low-permeability reservoirs. However, after a period of high yield from fracturing, the…”
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Mobilization of copper ions in human peripheral lymphocytes by catechins leading to oxidative DNA breakage: A structure activity study by Farhan, Mohd, Zafar, Atif, Chibber, Sandesh, Khan, Husain Yar, Arif, Hussain, Hadi, S.M.

“…•The number and position of hydroxyl group in the catechin skeleton determines the degree of cellular DNA breakage.•Hydroxyls ortho to each other provide a…”
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Tight gas production model considering TPG as a function of pore pressure, permeability and water saturation by Zafar, Atif, Su, Yu-Liang, Li, Lei, Fu, Jin-Gang, Mehmood, Asif, Ouyang, Wei-Ping, Zhang, Mian

“…Threshold pressure gradient has great importance in efficient tight gas field development as well as for research and laboratory experiments. This experimental…”
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Cerebrovascular and cardiovascular disease burden in patients with hereditary hemorrhagic telangiectasia by Farooqui, Mudassir, Suriya, Sajid, Qeadan, Fares, Vigil, Catherine, Wegele, Ashley, Ikram, Asad, Quadri, Syed A., Robinson, Myranda, Rodriguez-Lopez, Josanna, Ortega-Gutierrez, Santiago, Zafar, Atif

“…Introduction Hereditary hemorrhagic telangiectasia (HHT) is a rare genetic disease with prevalence of approximately 1 in 5000–10,000. We evaluated the…”
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Intracranial Hemorrhage Rate and Lesion Burden in Patients With Familial Cerebral Cavernous Malformation by Weinsheimer, Shantel, Nelson, Jeffrey, Abla, Adib A, Ko, Nerissa U, Tsang, Cynthia, Okoye, Obiora, Zabramski, Joseph M, Akers, Amy, Zafar, Atif, Mabray, Marc C, Hart, Blaine L, Morrison, Leslie, McCulloch, Charles E, Kim, Helen

“…Background Familial cerebral cavernous alformation (CCM) is an autosomal dominant disease caused by mutations in , , or . Cases typically present with multiple…”
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Cerebral vascular malformations and their imaging modalities by Zafar, Atif, Fiani, Brian, Hadi, Hamid, Arshad, Mohammad, Cathel, Alessandra, Naeem, Muhammad, Parsons, Matthew S., Farooqui, Mudassir, Bucklin, Abigail A., Leone, Michael J., Baig, Aqsa, Quadri, Syed A.

“…Cerebrovascular malformations are uncommon diverse group of dysmorphic vascular communications that may occur sporadically or as part of genetic syndromes…”
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Patterns of Care in Patients with Basilar Artery Occlusion (BAO): A Population-Based Study by Farooqui, Mudassir, Ikram, Asad, Suriya, Sajid, Qeadan, Fares, Bzdyra, Piotr, Quadri, Syed A, Zafar, Atif

“…Basilar artery occlusion (BAO) is associated with high morbidity and mortality. Endovascular therapy (EVT) has been shown to be beneficial in acute BAO…”
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Solid-liquid phase equilibria of H2O-Mn(H2PO2)2-MnCl2-NaCl, H2O-Mn(H2PO2)2-MnCl2 and (H2O-NaCl- MnCl2 systems at 323.15 K by Adiguzel, Vedat, Liu, Wei, Memon, Asadullah, Zhou, Hongtao, Akbar, Imran, Zafar, Atif, Ansari, Ubedullah

“…The solid?liquid phase equilibria (SLE) and densities of H2O?NaCl? ?MnCl2?Mn(H2PO2)2 quaternary system and H2O?NaCl?MnCl2 and H2O? ?MnCl2?Mn(H2PO2)2 ternary…”
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Bidirectionality of smoking and depression in adolescents: a systematic review by Farooqui, Mudassir, Shoaib, Samra, Afaq, Humera, Quadri, Syed, Zaina, Fatima, Baig, Aqsa, Liaquat, Ayesha, Sarwar, Zoona, Zafar, Atif, Younus, Sana

“…Abstract Introduction Recently, evidence has been accumulating that both smoking and mental health disorders are continuously increasing among adolescents…”
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