Search Results - "Zadie Davis"

Chromatin accessibility maps of chronic lymphocytic leukaemia identify subtype-specific epigenome signatures and transcription regulatory networks by Rendeiro, André F., Schmidl, Christian, Strefford, Jonathan C., Walewska, Renata, Davis, Zadie, Farlik, Matthias, Oscier, David, Bock, Christoph

“…Chronic lymphocytic leukaemia (CLL) is characterized by substantial clinical heterogeneity, despite relatively few genetic alterations. To provide a basis for…”
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Clinical significance of TP53, BIRC3, ATM and MAPK-ERK genes in chronic lymphocytic leukaemia: data from the randomised UK LRF CLL4 trial by Blakemore, Stuart J., Clifford, Ruth, Parker, Helen, Antoniou, Pavlos, Stec-Dziedzic, Ewa, Larrayoz, Marta, Davis, Zadie, Kadalyayil, Latha, Colins, Andrew, Robbe, Pauline, Vavoulis, Dimitris, Forster, Jade, Carr, Louise, Morilla, Ricardo, Else, Monica, Bryant, Dean, McCarthy, Helen, Walewska, Renata J., Steele, Andrew J., Chan, Jacqueline, Speight, Graham, Stankovic, Tanja, Cragg, Mark S., Catovsky, Daniel, Oscier, David G., Rose-Zerilli, Matthew J. J., Schuh, Anna, Strefford, Jonathan C.

“…Despite advances in chronic lymphocytic leukaemia (CLL) treatment, globally chemotherapy remains a central treatment modality, with chemotherapy trials…”
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Biallelic ATM Inactivation Significantly Reduces Survival in Patients Treated on the United Kingdom Leukemia Research Fund Chronic Lymphocytic Leukemia 4 Trial by SKOWRONSKA, Anna, PARKER, Anton, MOSS, Paul, THOMAS, Peter, OSCIER, David, STANKOVIC, Tatjana, AHMED, Gulshanara, OLDREIVE, Ceri, DAVIS, Zadie, RICHARDS, Sue, DYER, Martin, MATUTES, Estella, GONZALEZ, David, TAYLOR, A. Malcolm R

“…The prognostic significance of ATM mutations in chronic lymphocytic leukemia (CLL) is unclear. We assessed their impact in the context of a prospective…”
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Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma by Parry, Marina, Rose-Zerilli, Matthew J J, Gibson, Jane, Ennis, Sarah, Walewska, Renata, Forster, Jade, Parker, Helen, Davis, Zadie, Gardiner, Anne, Collins, Andrew, Oscier, David G, Strefford, Jonathan C

“…The pathogenesis of splenic marginal zone lymphoma (SMZL) remains largely unknown. Recent high-throughput sequencing studies have identified recurrent…”
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Prognostic factors identified three risk groups in the LRF CLL4 trial, independent of treatment allocation by OSCIER, David, WADE, Rachel, DAVIS, Zadie, MORILLA, Alison, BEST, Giles, RICHARDS, Sue, ELSE, Monica, MATUTES, Estella, CATOVSKY, Daniel

“…Many prognostic markers have been identified in chronic lymphocytic leukemia, but there have been few opportunities to assess their relative importance in a…”
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DLEU2, frequently deleted in malignancy, functions as a critical host gene of the cell cycle inhibitory microRNAs miR-15a and miR-16-1 by Lerner, Mikael, Harada, Masako, Lovén, Jakob, Castro, Juan, Davis, Zadie, Oscier, David, Henriksson, Marie, Sangfelt, Olle, Grandér, Dan, Corcoran, Martin M.

“…The microRNAs miR-15a and miR-16-1 are downregulated in multiple tumor types and are frequently deleted in chronic lymphocytic leukemia (CLL), myeloma and…”
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Immunoglobulin genes in chronic lymphocytic leukemia: key to understanding the disease and improving risk stratification by Sutton, Lesley-Ann, Hadzidimitriou, Anastasia, Baliakas, Panagiotis, Agathangelidis, Andreas, Langerak, Anton W, Stilgenbauer, Stephan, Pospisilova, Sarka, Davis, Zadie, Forconi, Francesco, Davi, Frederic, Ghia, Paolo, Rosenquist, Richard, Stamatopoulos, Kostas

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Multivariate analysis of prognostic factors in CLL: clinical stage, IGVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors by Oscier, David G., Gardiner, Anne C., Mould, Sarah J., Glide, Sharron, Davis, Zadie A., Ibbotson, Rachel E., Corcoran, Martin M., Chapman, Robert M., Thomas, Peter W., Copplestone, J. Adrian, Orchard, Jenny A., Hamblin, Terry J.

“…This study evaluates the prognostic significance of genetic abnormalities (detected at or shortly after presentation), clinical stage, lymphocyte morphology,…”
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Defining the prognosis of early stage chronic lymphocytic leukaemia patients by Pepper, Chris, Majid, Aneela, Lin, Thet Thet, Hewamana, Saman, Pratt, Guy, Walewska, Renata, Gesk, Stefan, Siebert, Reiner, Wagner, Simon, Kennedy, Ben, Miall, Fiona, Davis, Zadie A., Tracy, Ian, Gardiner, Anne C., Brennan, Paul, Hills, Robert K., Dyer, Martin J. S., Oscier, David, Fegan, Chris

“…Summary Approximately 70% of chronic lymphocytic leukaemia (CLL) patients present with early stage disease, therefore defining which patients will progress and…”
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Clinical significance of DNA methylation in chronic lymphocytic leukemia patients: results from 3 UK clinical trials by Wojdacz, Tomasz K., Amarasinghe, Harindra E., Kadalayil, Latha, Beattie, Alice, Forster, Jade, Blakemore, Stuart J., Parker, Helen, Bryant, Dean, Larrayoz, Marta, Clifford, Ruth, Robbe, Pauline, Davis, Zadie A., Else, Monica, Howard, Dena R., Stamatopoulos, Basile, Steele, Andrew J., Rosenquist, Richard, Collins, Andrew, Pettitt, Andrew R., Hillmen, Peter, Plass, Christoph, Schuh, Anna, Catovsky, Daniel, Oscier, David G., Rose-Zerilli, Matthew J.J., Oakes, Christopher C., Strefford, Jonathan C.

“…Chronic lymphocytic leukemia patients with mutated immunoglobulin heavy-chain genes (IGHV-M), particularly those lacking poor-risk genomic lesions, often…”
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Cell surface phenotype profiles distinguish stable and progressive chronic lymphocytic leukemia by Huang, Pauline Y., Best, Oliver G., Almazi, Juhura G., Belov, Larissa, Davis, Zadie A., Majid, Aneela, Dyer, Martin J., Pascovici, Dana, Mulligan, Stephen P., Christopherson, Richard I.

“…Abstract Chronic lymphocytic leukemia (CLL) is clinically heterogeneous. While some patients have indolent disease for many years, 20-30% will progress and…”
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Toll-like receptor stimulation in splenic marginal zone lymphoma can modulate cell signaling, activation and proliferation by Fonte, Eleonora, Agathangelidis, Andreas, Reverberi, Daniele, Ntoufa, Stavroula, Scarfò, Lydia, Ranghetti, Pamela, Cutrona, Giovanna, Tedeschi, Alessandra, Xochelli, Aliki, Caligaris-Cappio, Federico, Ponzoni, Maurilio, Belessi, Chrysoula, Davis, Zadie, Piris, Miguel A, Oscier, David, Ghia, Paolo, Stamatopoulos, Kostas, Muzio, Marta

“…Recent studies on splenic marginal zone lymphoma identified distinct mutations in genes belonging to the B-cell receptor and Toll-like receptor signaling…”
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Determination of how many immunoglobulin variable region heavy chain mutations are allowable in unmutated chronic lymphocytic leukaemia – long‐term follow up of patients with different percentages of mutations by Hamblin, Terry J., Davis, Zadie A., Oscier, David G.

“…Summary The choice of 98% sequence homology for immunoglobulin heavy chains to distinguish between mutated and unmutated versions of chronic lymphocytic…”
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CBL-MZ is not a single biological entity: evidence from genomic analysis and prolonged clinical follow-up by Parker, Helen, McIver-Brown, Neil Robert, Davis, Zadie A., Parry, Marina, Rose-Zerilli, Matthew J.J., Xochelli, Aliki, Gibson, Jane, Walewska, Renata, Strefford, Jonathan C., Oscier, David G.

“…[Display omitted]…”
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Divergence from the germ-line sequence in unmutated chronic lymphocytic leukemia is due to somatic mutation rather than polymorphisms by Davis, Zadie A., Orchard, Jenny A., Corcoran, Martin M., Oscier, David G.

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Clonal lineage analysis of CLL research samples by IGH chain sequencing to reveal novel CLL subgroups defined by ongoing class-switch recombination and somatic hypermutation by Looney, Timothy, Quest, Graeme, Feilotter, Harriet, Davis, Zadie

“…Abstract only e20001 Background: B cell somatic hypermutation (SHM) and class switch recombination (CSR) are mechanistically related but distinct processes…”
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Importance of sequential analysis of TP53 variation in patients with Waldenström Macroglobulinaemia by Christian, Amy, Davis, Zadie, Walewska, Renata, McCarthy, Helen

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Importance of sequential analysis of TP 53 variation in patients with Waldenström Macroglobulinaemia by Christian, Amy, Davis, Zadie, Walewska, Renata, McCarthy, Helen

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Immunoglobulin gene sequence analysis in chronic lymphocytic leukemia: the 2022 update of the recommendations by ERIC, the European Research Initiative on CLL by Agathangelidis, Andreas, Chatzidimitriou, Anastasia, Chatzikonstantinou, Thomas, Tresoldi, Cristina, Davis, Zadie, Giudicelli, Véronique, Kossida, Sofia, Belessi, Chrysoula, Rosenquist, Richard, Ghia, Paolo, Langerak, Anton W., Davi, Frédéric, Stamatopoulos, Kostas

“…The somatic hypermutation (SHM) status of the clonotypic immunoglobulin heavy variable (IGHV) gene is a critical biomarker for assessing the prognosis of…”
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Cytogenetic complexity in chronic lymphocytic leukemia: definitions, associations, and clinical impact by Baliakas, Panagiotis, Jeromin, Sabine, Iskas, Michalis, Puiggros, Anna, Plevova, Karla, Nguyen-Khac, Florence, Davis, Zadie, Rigolin, Gian Matteo, Visentin, Andrea, Xochelli, Aliki, Delgado, Julio, Baran-Marszak, Fanny, Stalika, Evangelia, Abrisqueta, Pau, Durechova, Kristina, Papaioannou, George, Eclache, Virginie, Dimou, Maria, Iliakis, Theodoros, Collado, Rosa, Doubek, Michael, Calasanz, M. Jose, Ruiz-Xiville, Neus, Moreno, Carolina, Jarosova, Marie, Leeksma, Alexander C., Panayiotidis, Panayiotis, Podgornik, Helena, Cymbalista, Florence, Anagnostopoulos, Achilles, Trentin, Livio, Stavroyianni, Niki, Davi, Fred, Ghia, Paolo, Kater, Arnon P., Cuneo, Antonio, Pospisilova, Sarka, Espinet, Blanca, Athanasiadou, Anastasia, Oscier, David, Haferlach, Claudia, Stamatopoulos, Kostas

“…Recent evidence suggests that complex karyotype (CK) defined by the presence of ≥3 chromosomal aberrations (structural and/or numerical) identified by using…”
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