Search Results - "Zack Howard, O.M."

Leukocyte-derived koebnerisin (S100A15) and psoriasin (S100A7) are systemic mediators of inflammation in psoriasis by Batycka-Baran, Aleksandra, Hattinger, Eva, Zwicker, Stephanie, Summer, Burkhard, Zack Howard, O.M, Thomas, Peter, Szepietowski, Jacek C, Ruzicka, Thomas, Prinz, Jörg C, Wolf, Ronald

“…Highlights • Leukocytes are a novel source of koebnerisin (S100A15) and psoriasin (S100A7). • Koebnerisin and psoriasin are induced in leukocytes of patients…”
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The Alarmin HMGN1 contributes to antitumor immunity and is a potent immunoadjuvant by Wei, Feng, Yang, De, Tewary, Poonam, Li, Yana, Li, Sandra, Chen, Xin, Howard, O M Zack, Bustin, Michael, Oppenheim, Joost J

“…Alarmins are endogenous mediators that are elicited rapidly in response to danger signals, enhancing innate and adaptive immune responses by promoting the…”
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Myeloid cells migrate in response to IL-24 by Buzas, Krisztina, Oppenheim, Joost J., Zack Howard, O.M.

“…► IL-24 induces human monocyte and neutrophil migration, in vitro. ► IL-24 attracted CD11b positive murine myeloid cells, in vivo. ► Pertussis toxin, MEK and…”
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Interleukin-8-like activity in a filarial asparaginyl-tRNA synthetase by Kron, Michael A., Wang, Cheng, Vodanovic-Jankovic, Sanja, Zack Howard, O.M., Kuhn, Leslie A.

“…[Display omitted] Brugia malayi AsnRS has IL-8 like activity. ► IL-8-like activity resides in the tRNA binding domain of the filarial AsnRS. ► Structural…”
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Induction of dendritic cell maturation by pertussis toxin and its B subunit differentially initiate Toll-like receptor 4–dependent signal transduction pathways by Wang, Zhao Yuan, Yang, De, Chen, Qian, Leifer, Cindy A., Segal, David M., Su, Shao Bo, Caspi, Rachel R., Howard, Zack O.M., Oppenheim, Joost J.

“…Pertussis toxin (PT) has the capacity to activate dendritic cells (DCs) for the augmentation of cell-mediated immune responses. To investigate the mechanism(s)…”
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Identification of human neutrophil-derived cathepsin G and azurocidin/CAP37 as chemoattractants for mononuclear cells and neutrophils by Chertov, O, Ueda, H, Xu, L L, Tani, K, Murphy, W J, Wang, J M, Howard, O M, Sayers, T J, Oppenheim, J J

“…Macrophage infiltration into inflammatory sites is generally preceded by neutrophils. This suggests neutrophils may be the source of chemotactic factors for…”
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Monocyte Chemotactic Protein-2 Activates CCR5 and Blocks CD4/CCR5-mediated HIV-1 Entry/Replication by Gong, W, Howard, O M, Turpin, J A, Grimm, M C, Ueda, H, Gray, P W, Raport, C J, Oppenheim, J J, Wang, J M

“…Human immunodeficiency virus, type I (HIV-1) cell-type tropism is dictated by chemokine receptor usage: T-cell line tropic viruses use CXCR4, whereas monocyte…”
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Prolactin recruits STAT1, STAT3 and STAT5 independent of conserved receptor tyrosines TYR402, TYR479, TYR515 and TYR580 by DaSilva, Luis, Rui, Hallgeir, Erwin, Rebecca A., Zack Howard, O.M., Kirken, Robert A., Malabarba, Maria G., Hackett, Rebecca H., Larner, Andrew C., Farrar, William L.

“…The present study of prolactin (PRL) receptor-mediated recruitment of signal transducers and activators of transcription (STATs) demonstrates that PRL…”
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TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T. cell phenotype in the inflammatory environment by Chen, Xin, Wu, Xueqiang, Zhou, Qiong, Howard, O M Zack, Netea, Mihai G, Oppenheim, Joost J

“…Several lines of evidence indicate the instability of CD4(+)Foxp3(+) regulatory T cells (Tregs). We have therefore investigated means of promoting the…”
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Co-expression of TNFR2 and CD25 identifies more of the functional CD4⁺FOXP3⁺ regulatory T cells in human peripheral blood by Chen, Xin, Subleski, Jeffrey J, Hamano, Ryoko, Howard, O.M. Zack, Wiltrout, Robert H, Oppenheim, Joost J

“…Previously, we found that co-expression of CD25 and TNFR2 identified the most suppressive subset of mouse Treg. In this study, we report that human peripheral…”
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Enhanced immunostimulatory effects of DNA-encapsulated peptide hydrogels by Medina, Scott H, Li, Sandra, Howard, O.M. Zack, Dunlap, Micah, Trivett, Anna, Schneider, Joel P, Oppenheim, Joost J

“…Abstract DNA that encodes tumor-specific antigens represents potential immunostimulatory agents. However, rapid enzymatic degradation and fragmentation of DNA…”
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Fufang Kushen injection inhibits sarcoma growth and tumor-induced hyperalgesia via TRPV1 signaling pathways by Zhao, Zhizheng, Fan, Huiting, Higgins, Tim, Qi, Jia, Haines, Diana, Trivett, Anna, Oppenheim, Joost J, Wei, Hou, Li, Jie, Lin, Hongsheng, Howard, O.M. Zack

“…Highlights • Cancer Pain correlates with TRPV1-mediated ERK phosphorylation. • Fufang Kushen Injection reduces thermal hyperalgesia induced by sarcoma. •…”
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Gene from a psoriasis susceptibility locus primes the skin for inflammation by Wolf, Ronald, Mascia, Francesca, Dharamsi, Alif, Howard, O M Zack, Cataisson, Christophe, Bliskovski, Val, Winston, Jason, Feigenbaum, Lionel, Lichti, Ulrike, Ruzicka, Thomas, Chavakis, Triantafyllos, Yuspa, Stuart H

“…Psoriasis is a common complex genetic disease characterized by hyperplasia and inflammation in the skin; however, the relative contributions of epidermal cells…”
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Abstract 3585: Metastasis of 4T1 murine breast cancer cells to the lung is dependent on the chemokine CCL2/MCP-1 produced by stromal cells in the primary tumor by Yoshimura, Teizo, Howard, O.M. Zack, Ito, Toshihiro, Kuwabara, Masaki, Matsukawa, Akihiro, Chen, Keqiang, Liu, Ying, Liu, Mingyong, Wang, Ji Ming

“…Abstract The chemokine CCL2, also known as MCP-1, plays an important role in the initiation and progression of cancer. Since tumor cells produce CCL2, they are…”
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IKKalpha is critical for the maintenance of a normal pool of regulatory T cells and for the expansion of both regulatory and effector T cells (P1095) by Chen, Xin, Willette-Brown, Jami, Wu, Xueqiang, Howard, O.M. Zack, Hu, Yinling, Oppenheim, Joost

“…Abstract Our previous studies show that TNF activates and expands Tregs through TNFR2. It was reported that TNF-TNFR2 interaction results in the activation of…”
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Structural plasticity of a transmembrane peptide allows self-assembly into biologically active nanoparticles by Tarasov, Sergey G, Gaponenko, Vadim, Howard, O.M. Zack, Chen, Yuhong, Oppenheim, Joost J, Dyba, Marzena A, Subramaniam, Sriram, Lee, Youngshim, Michejda, Christopher, Tarasova, Nadya I

“…Significant efforts have been devoted to the development of nanoparticular delivering systems targeting tumors. However, clinical application of nanoparticles…”
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In vitro generated Th17 cells support the expansion and phenotypic stability of CD4+Foxp3+ regulatory T cells in vivo by Zhou, Qiong, Hu, Ya, Howard, O.M. Zack, Oppenheim, Joost J., Chen, Xin

“…•Th17 cells express the highest levels of TNF than other Th subsets.•Th17 cells most potently stimulate co-transferred Tregs in Rag1 KO mice.•This effect of…”
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Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells by Howard, O M Zack, Dong, Hui Fang, Yang, De, Raben, Nina, Nagaraju, Kanneboyina, Rosen, Antony, Casciola-Rosen, Livia, Härtlein, Michael, Kron, Michael, Yang, David, Yiadom, Kwabena, Dwivedi, Sunita, Plotz, Paul H, Oppenheim, Joost J

“…Autoantibodies to histidyl-tRNA synthetase (HisRS) or to alanyl-, asparaginyl-, glycyl-, isoleucyl-, or threonyl-tRNA synthetase occur in approximately 25% of…”
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Transactivation of the epidermal growth factor receptor by formylpeptide receptor exacerbates the malignant behavior of human glioblastoma cells by JIAN HUANG, JINYUE HU, XIUWU BIAN, KEQIANG CHEN, WANGHUA GONG, DUNLOP, Nancy M, ZACK HOWARD, O. M, JI MING WANG

“…The G protein-coupled formylpeptide receptor (FPR), which mediates leukocyte migration in response to bacterial and host-derived chemotactic peptides, promotes…”
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Melanoma cell-derived exosomes alter macrophage and dendritic cell functions in vitro by Marton, Annamaria, Vizler, Csaba, Kusz, Erzsebet, Temesfoi, Viktoria, Szathmary, Zsuzsa, Nagy, Krisztina, Szegletes, Zsolt, Varo, Gyorgy, Siklos, Laszlo, Katona, Robert L, Tubak, Vilmos, Howard, O.M. Zack, Duda, Erno, Minarovits, Janos, Nagy, Katalin, Buzas, Krisztina

“…Highlights ► B16 melanomas produce exosomes of 30–70 nm diameter. ► The exosomes help the functional maturation of allogeneic dendritic cells. ► The exosomes…”
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